Navigation Links
Sanofi and Regeneron Report Positive Results with Sarilumab in First Phase 3 Rheumatoid Arthritis Registration Trial
Date:11/22/2013

ent Question-Disability (HAQ-DI) at week 16. 

(3) Inhibition of progression of structural damage at Week 52, as measured by the change in the modified Van der Heijde total Sharp score (mTSS).

  • 0.25, 0.90, and 2.78 in the sarilumab 200 mg, sarilumab 150 mg, and placebo groups respectively, all in combination with MTX.
  • The group receiving the 200 mg dose of sarilumab + MTX had a reduction of approximately 90 percent in the radiographic progression assessed by the mTSS compared to the radiographic progression with placebo + MTX at week 52.
  • ACR Results at week 24 Treatment Group

    ACR20
    (%)ACR50

    (%)ACR70

    (%)200 mg sarilumab + MTX

    66*

    46*

    25*150 mg sarilumab + MTX

    58*

    37*

    20*Placebo + MTX

    33

    17

    7



    Primary Endpoint
    *p<0.0001 compared to placebo group

    In the SARIL-RA-MOBILITY trial, there was a higher incidence of treatment emergent adverse events leading to withdrawal in the sarilumab treatment groups compared to placebo (13.9 percent in 200 mg, 12.5 percent in 150 mg and 4.7 percent in placebo). 

    Infections were the most frequently reported adverse events and were reported with a higher incidence in the sarilumab groups compared to placebo, all in combination with MTX (39.6 percent for 200 mg, 40.1 percent for the 150 mg group and 31.1 percent for placebo).  The incidence of serious infections was 4.0 percent in the 200 mg + MTX group, 2.6 percent in the 150 mg + MTX group, and 2.3 percent in the placebo + MTX group.  Among patients treated with sarilumab, a dose dependent decrease in mean neutrophil counts was observed.  Serious infections were not associated with grades 3 and 4 neutropenia in this study.  Increases in mean LDL cholesterol, and transaminases were observed. &
    '/>"/>

    SOURCE Regeneron Pharmaceuticals, Inc.
    Copyright©2012 PR Newswire.
    All rights reserved

    Page: 1 2 3 4 5 6 7

    Related medicine technology :

    1. Sanofi Pasteur Presents Pediatric Data on Investigational Quadrivalent Influenza Vaccine
    2. Sanofi US Launches Collaborate Activate Innovation Challenge
    3. Sanofi Pasteur to add 2D barcode to six more vaccines
    4. Sanofi and Regeneron Announce Publication of Phase 2 Results with LDL Cholesterol-Lowering PCSK9 Antibody in the New England Journal of Medicine
    5. Sanofi and Regeneron Announce Patient Enrollment in Cardiovascular Outcomes Trial with Antibody to PCSK9 for Hypercholesterolemia
    6. Sanofi and T1D Exchange to Launch Worldwide Study to Investigate Factors for Optimal Care for Young People with Diabetes
    7. Sanofi Donates $500,000 to Hurricane Sandy for Immediate and Long-Term Relief Efforts
    8. Phase II Trial of Sanofi JAK2 Inhibitor in Myelofibrosis Met Primary Endpoint
    9. Sanofi Launches Breakthrough Technology for Cardiovascular and Vascular Surgery Procedures
    10. Zacks Bull and Bear of the Day Highlights: Smithfield Foods, Logitech International, Sanofi, Isis Pharmaceuticals and Aegerion Pharmaceuticals
    11. Sanofi New Drug Application for Lixisenatide Accepted for Review by FDA
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:1/23/2015)... available for sale, The Armor1 Ankle Roll Guard is a ... by cushioning the ankle from an inversion or "roll." ... of any shoe type and allows the user to ... against sprains. With customers in physical therapy, podiatry, and ...
    (Date:1/23/2015)... Blood America, Inc. ( www.cordblood-america.com ) (OTC Bulletin Board: ... Proxy Statement, Schedule 14A, with the U.S. Securities & Exchange ... shareholders detailing why a "YES" vote to increase the number ... As we reflect upon the 2014 fiscal year that ...
    (Date:1/23/2015)... DUBLIN , Jan. 23, 2015  Mallinckrodt plc (NYSE: ... of Directors has approved a share repurchase program. The ... $300 million of Mallinckrodt plc ordinary shares. ... opportunities remain top priorities as we continue to pursue ...
    Breaking Medicine Technology:The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4
    (Date:1/22/2015)... Gabe’s Chemo Duck Program is pleased to announce the release of ... kids with cancer. The Chemo Duck App, available on iTunes for ... games to help children of all ages living with cancer adjust ... kids entertained, educated and at ease while waiting for clinic visits ...
    (Date:1/22/2015)... VogueQueen is a seasoned and trusted leader who consistently delivers ... to have it lead the wedding dress industry into the ... dresses for the global market. , “The CEO of VogueQueen ... focuses on continuing the goal of operational excellence and giving ...
    (Date:1/22/2015)... (PRWEB) January 23, 2015 Angelweddingdress is a ... business invites its customers to follow it on Facebook, Twitter, ... a Valentine’s Day gift. Angelweddingdress draws a lottery every week. ... Sale to Feb. 28, 2015. Click Angelweddingdress homepage ...
    (Date:1/22/2015)... the premier women’s dress supplier, has recently released its ... of AngelWeddingDress.com to find more details. , Many ... a bridal party. AngelWeddingDress offers a variety of gorgeous ... wedding dresses are specially designed for 2015. , AngelWeddingDress ...
    (Date:1/22/2015)... 2015 Juvent Sports ( http://www.juventsports.com ) ... PGA Merchandise Show to bestow a Juvent Sports Achievement ... golfer, Arlene McKitrick. The award commemorated and congratulated McKitrick ... win. She won her first amateur tournament in 1979 ...
    Breaking Medicine News(10 mins):Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3
    ... disease is usually accepted as a hazard of aging, ... are a consequence of aging// or not. Researchers at ... Research Institute have now conducted a study that proves ... Alzheimer's. ,Harmful beta amyloid aggregates accumulate when ...
    ... the number of drug users who completed the treatment for drug ... number of people enrolling// for the treatment in this period. Drug ... had been coerced into it by the criminal justice system than ... a British study of the outcome of treatment for drug addiction, ...
    ... in the American Society, not only among women but also ... under pressure to have a good physique may suffer from ... with weightlifting. ,“Men see these idealized, muscular men ... up,” said Tracy Tylka, author of the study and assistant ...
    ... time for one to undergo an operation.// ,A ... has analysed the outcomes of over 90,000 operations carried out ... best time to have an operation, as they had found ... have published their study in the journal Quality and Safety ...
    ... announced that it will be publishing a peer-reviewed ... is. RESPeRATE, a over-the-counter// therapeutic device that is ... to treat hypertension, the study says. ... (http://www.medscape.com/viewarticle/539099) of Medscape (NASDAQ:WBMD), is authored by William ...
    ... research in mice has found that though they do not ... were able to differentiate the cells// in the sebaceous glands ... how a sebaceous gland is formed. ,In new ... Fuchs, a Howard Hughes Medical Institute investigator at Rockefeller University, ...
    Cached Medicine News:Health News:Aging Critical For Alzheimer's Disease 2Health News:Aging Critical For Alzheimer's Disease 3Health News:Men Take to Unhealthy Practices to be More Muscular 2Health News:Surgeries Performed In The Morning Have Less Post-Op Complications 2Health News:New Treatment Mooted For Blood Pressure 2Health News:'Blimp1' Gene Linked To Oily Skin 2
    This optimal design addresses low-cost, simple, non-invasive ankle distraction....
    A straightforward, versatile approach to arthroscopically assisted pin placement in either the ankle or wrist....
    ... The BTA stat Test is ... the qualitative detection of bladder ... diagnosed with bladder cancer. This ... an aid in the management of ...
    ThyroTest by ThyroTec, Inc. is a rapid immunoassay, similar to a rapid pregnancy test. By using 2 drops of blood from a finger stick and 5 drops of diluent, a qualitative TSH level is inicated in min...
    Medicine Products: