Navigation Links
Sanofi and Regeneron Report Positive Phase 2b Trial Results with Sarilumab in Rheumatoid Arthritis
Date:7/12/2011

kine-mediated inflammatory signaling cascade. Sarilumab was developed using Regeneron VelocImmune® antibody technology.  

About the MOBILITY TrialThe MOBILITY trial is a randomized, double-blind, placebo-controlled, multicenter, two-part, dose ranging and confirmatory study with an operationally seamless design, evaluating efficacy and safety of sarilumab on top of MTX in patients with active RA who are inadequate responders to MTX therapy.  The primary objective of part A of the dose ranging MOBILITY trial was to demonstrate that sarilumab on top of MTX is effective in reducing the signs and symptoms of RA at 12 weeks.  The five doses tested were 100 milligrams (mg) and 150 mg every week and 100 mg, 150 mg and 200 mg every other week.  The primary objective of part B of the MOBILITY trial will be to demonstrate that sarilumab on top of MTX is effective in reducing the signs and symptoms of RA at 24 weeks.  Further details about the MOBILITY trial are available at http://clinicaltrials.gov/ct2/results?term=SAR+153191+mobility.

About Rheumatoid ArthritisRheumatoid arthritis (RA) is a chronic systemic autoimmune disease affecting approximately 0.5%–1% of the global adult population.  Abnormal immune response causes an inflamed, thickened synovium, the membrane that lines the joint.  As synovitis expands, the inflammatory process can damage the bone and cartilage of the joint and the surrounding tissues.  RA-related inflammation can involve the heart and the lung.  In 10% of patients with RA the liver is affected. Complications of RA include anemia and leucopenia.  At times RA can be very painful and affect a person's ability to carry out everyday tasks.  Most people with RA experience periods when their symptoms worsen (flares or active disease) separated by periods in which the symptoms improve.
'/>"/>

SOURCE Regeneron Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Sanofi Divests Dermik Dermatology Unit to Valeant Pharmaceuticals International, Inc.
2. Sanofi Enters Into Research Collaboration with Weill Cornell Medical College to Discover New Treatments for Tuberculosis
3. Sanofi Pasteur Commends Winners of International BioGENEius Challenge
4. Sanofi Announces Positive Results from the "All to Target" Study Evaluating Two Lantus® and Apidra® Regimens Versus Premixed Regimen
5. Medco, United BioSource and Sanofi Signed Global Agreement to Improve Quality of Patient Care Through Real-World Evidence
6. Sanofi Enters Into Research Collaboration With Biopharmaceutical Company Audion Therapeutics to Develop Potential Treatments for Hearing Loss
7. Sanofi Pasteur Donates Tdap Vaccine to Aid Storm Victims
8. sanofi-aventis: Strong Performance of Growth Platforms in Q1 2011
9. Sanofi Pasteur Announces FDA Approval of Menactra Meningococcal Conjugate Vaccine Indication for Infants
10. Sanofi-aventis Enters into Collaboration Agreement with Stanford University Bio-X to Focus on Early-Stage Scientific Research
11. Sanofi-Aventis Completes Acquisition of Genzyme Corporation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... 2013  An international roster of experts on malignant ... Santa Monica, Calif. , to discuss ... MPM, a rare form of cancer that results from ... lining of the chest. Hosted by UCLA ... 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant ...
(Date:5/24/2013)... 24, 2013  Sinovac Biotech Ltd. (NASDAQ: ... products in China , announced ... of Sinovac, obtained the Certificate of Good Manufacturing ... China State and Food Administration (CFDA) for its ... and its Changping filing and packaging facility. The ...
(Date:5/23/2013)... y PARÍS, 24 de mayo de 2013 ... un destacado desarrollador y fabricante de herramientas de ... diagnosis y tratamiento de la enfermedad vascular periférica ... ensayo ADVISE ( Ad enosine V asodilator ... valuation) II durante la sesión de ensayo clínico ...
Breaking Medicine Technology:International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 2International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 3Sinovac Beijing Obtains China GMP Certificate Under the New GMP Guidelines 2Sinovac Beijing Obtains China GMP Certificate Under the New GMP Guidelines 3Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 2Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 3Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 4Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 5Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 6
... QUAD Cinema , one of New York City,s leading art ... documentary, 3 BILLION AND COUNTING (102 ... Sure to spark outrage, Dr. Rutledge, a California physician ... ban on the pesticide DDT in 1972, a ban inspired ...
... The following is a statement issued today ... and CEO Steven C. Anderson, IOM, CAE, and National ... CEO Douglas Hoey, RPh, regarding the proposed rule by ... would withdraw existing provisions of the Medicaid pharmacy reimbursement ...
Cached Medicine Technology:3 BILLION AND COUNTING Opens in New York at The QUAD Cinema 23 BILLION AND COUNTING Opens in New York at The QUAD Cinema 3NACDS, NCPA: Victory for Patients, Pharmacy as CMS Moves to Withdraw Provisions of 'AMP' Rule Currently Blocked by Injunction 2NACDS, NCPA: Victory for Patients, Pharmacy as CMS Moves to Withdraw Provisions of 'AMP' Rule Currently Blocked by Injunction 3
(Date:5/24/2013)... Started in 1982, AMTC’s SHINE event is a biannual ... anniversary. SHINE is a ministry run by three generations of ... daughter, Carey Lewis Arban. , This summer’s SHINE will be ... including the New York Film Academy, The New York Conservatory ... Hollywood and Christian casting directors. They seek top talent ...
(Date:5/24/2013)... Area homeowners dreaming about owning a hot tub ... choose from at factory-direct pricing during the Jacuzzi Hot ... place at Emerald Pool and Patio in Bend, ... industry's leading hot tub brand, scheduled the event as part ... will feature popular hot tub models at up to 50% ...
(Date:5/24/2013)... 24, 2013 Mr. Brian Su, CEO ... Annual EB-5 Investment Summit: Dealmakers Conference in Long Beach, ... focus on exploring alternative finance through EB-5 immigrant investors ... and economic information, and updates to project developers, regional ... industry. , "Our goal is to assist EB-5 ...
(Date:5/24/2013)... BestSatelliteProviders.com the online satellite TV and ... compare the features and services offered by leading ... the rankings of the best rural Internet ... on their website. , BestSatelliteProviders.com – ... Matthews, the spokesperson for BestSatelliteProviders.com, “When consumers were ...
(Date:5/24/2013)... May 24 (HealthDay News) -- Low-income, minority parents ... activity and are more open to vaccinating their ... a small new study contends. Conversely, white, ... vaccination for their daughters, according to researchers from ... 33,000 Americans will get an HPV-related cancer each ...
Breaking Medicine News(10 mins):Health News:AMTC’s Summer SHINE Event Coming to Orlando’s Luxurious Gaylord Palms July 2-7, 2013 2Health News:Truckload of Jacuzzi® Hot Tubs Rolls into Bend, Oregon on May 24, 2013 for Sales Event 2Health News:Brian Su Organizes 3rd Annual EB-5 Investment Conference in Long Beach, California 2Health News:Best Rural Internet Service Provider in 2013 by BestSatelliteProviders.com 2Health News:Low-Income, Minority Parents More Open to HPV Vaccine for Girls, Study Says 2
... study it is observed that the background of the ... at the University of Glasgow have surveyed 4,139 melanoma ... 1999.// They found the outcomes to be similar, whether ... work, or general surgery. This is in contrast to ...
... Albert Einstein College of Medicine, they have observed that ... predict who will develop a form of dementia later ... Medicine finds the presence of an abnormal gait in ... dementia. The form of dementia is non-Alzheimer's dementia. ...
... a new study it is observed that statins reduce the ... statins lowers cholesterol// levels and so lowers the risk of ... in middle-aged people, but the benefits for the elderly have ... of Glasgow have assessed the benefit of treatment with the ...
... have observed that doctors should use lower thresholds when ... in ethnic minorities.// Researchers at St George's Hospital, Georgia ... and women of various ethnic origins, looking at their ... people of African origin have the lowest risk of ...
... is observed that susceptibility to lead is still a ... in blood over the past two decades. Previous ... factor and potential// cause for cancer, kidney disease, cardiovascular ... a small number of studies to investigate the connection ...
... According to researchers in a study working with animals ... and learning. Although the research is early, they say ... memory and learning disorders. Researchers say previous research into ... genes and didn't provide a comprehensive understanding of how ...
Cached Medicine News:
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: