Navigation Links
Sanofi and Regeneron Report Positive Phase 2b Trial Results with Sarilumab in Rheumatoid Arthritis
Date:7/12/2011

PARIS and TARRYTOWN, N.Y., July 12, 2011 /PRNewswire/ -- Sanofi (EURONEXT: SAN and NYSE: SNY) and Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced results from Phase 2b trials in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) with sarilumab (REGN88/SAR153191), a novel, high-affinity, subcutaneously administered, fully-human antibody targeting the interleukin-6 receptor (IL-6R).

The Phase 2b MOBILITY trial in rheumatoid arthritis demonstrated that patients treated with sarilumab in combination with a standard RA treatment, methotrexate (MTX), achieved a significant and clinically meaningful improvement in signs and symptoms of moderate-to-severe RA compared to patients treated with MTX alone.  The MOBILITY study is a 306-patient, dose-ranging, multi-national, randomized, multi-arm, double-blind, placebo-controlled study, that compared five different dose regimens of sarilumab in combination with MTX to placebo plus MTX.  The primary endpoint of the study was the proportion of patients achieving at least a 20% improvement in RA symptoms (ACR20) after 12 weeks.

In the MOBILITY trial, there was a dose response observed in patients receiving sarilumab in combination with MTX.  An ACR20 response after 12 weeks was seen in 49.0% of patients receiving the lowest sarilumab dose regimen and 72.0% of patients receiving the highest dose regimen compared to 46.2% of patients receiving placebo and MTX (p=0.02, corrected for multiplicity, for the highest sarilumab dose regimen).  The most common adverse events (>5%) reported more frequently in active treatment arms included infections (non-serious), neutropenia, and liver function test abnormalities.  The types and frequencies of adverse events were consistent with those previously reported with
'/>"/>

SOURCE Regeneron Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Sanofi Divests Dermik Dermatology Unit to Valeant Pharmaceuticals International, Inc.
2. Sanofi Enters Into Research Collaboration with Weill Cornell Medical College to Discover New Treatments for Tuberculosis
3. Sanofi Pasteur Commends Winners of International BioGENEius Challenge
4. Sanofi Announces Positive Results from the "All to Target" Study Evaluating Two Lantus® and Apidra® Regimens Versus Premixed Regimen
5. Medco, United BioSource and Sanofi Signed Global Agreement to Improve Quality of Patient Care Through Real-World Evidence
6. Sanofi Enters Into Research Collaboration With Biopharmaceutical Company Audion Therapeutics to Develop Potential Treatments for Hearing Loss
7. Sanofi Pasteur Donates Tdap Vaccine to Aid Storm Victims
8. sanofi-aventis: Strong Performance of Growth Platforms in Q1 2011
9. Sanofi Pasteur Announces FDA Approval of Menactra Meningococcal Conjugate Vaccine Indication for Infants
10. Sanofi-aventis Enters into Collaboration Agreement with Stanford University Bio-X to Focus on Early-Stage Scientific Research
11. Sanofi-Aventis Completes Acquisition of Genzyme Corporation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... 2015 RadiologyAuction will have their first auction starting ... demonstrations at the end of the auction on May ... and Fuji Cr,s, Agfa and Sony, printers and GE ... Various imaging equipment will be available at later auctions ... years of buying and selling imaging equipment, the brokers ...
(Date:5/4/2015)... May 4, 2015  Makindus, Inc. a specialty pharmaceutical ... European Medicines Agency (EMA) has granted orphan drug designation ... Stargardt,s Disease. "We are extremely pleased to ... Stargardt,s disease in place for Europe ... the United States for which ...
(Date:5/4/2015)... May 4, 2015   HeartWare International, Inc . (NASDAQ: ... circulatory support technologies that are revolutionizing the treatment of advanced ... Godshall , is scheduled to present at the Bank of ... Las Vegas on Thursday, May 14, 2015, at ... webcast of the Company,s presentation at the conference will be ...
Breaking Medicine Technology:RadiologyAuction Announces Event Starting On May 5th 2European Medicines Agency (EMA) Grants Orphan Designation for Makindus' MI-100 for Stargardt's Disease 2HeartWare Presentation At Bank Of America Merrill Lynch 2015 Health Care Conference To Be Webcast 2
... 2007 - The University of,Pittsburgh School of ... release, "Scientists Culture Blood-Forming Stem Cells from,Human ... "Researchers at,the University of Pittsburgh School of ... stem cells from fat, or,adipose tissue, suggesting ...
... Potential of ONCONASE for,Treatment of Neuroblastoma, BLOOMFIELD, ... today announced that new data show ONCONASE,the ... naive and,chemoresistant neuroblastoma cells. , The pre-clinical ... in Cancer,Letters (2007; Vol. 250, Issue 1: ...
Cached Medicine Technology:Bio-Matrix Scientific's Dr. O'Neill Sees University of Pittsburgh's,Published Study on Culture Blood-Forming Stem Cells from Human Fat,Tissue as Supporting Near Term Benefits of Banking Adipose (Fat),Derived Stem Cells 2Bio-Matrix Scientific's Dr. O'Neill Sees University of Pittsburgh's,Published Study on Culture Blood-Forming Stem Cells from Human Fat,Tissue as Supporting Near Term Benefits of Banking Adipose (Fat),Derived Stem Cells 3In Vitro and In Vivo Data Show Alfacell's Onocanse is Active,Against Naive and Chemoresistant Neuroblastoma Cells 2In Vitro and In Vivo Data Show Alfacell's Onocanse is Active,Against Naive and Chemoresistant Neuroblastoma Cells 3
(Date:5/4/2015)... Johnson & Wales University (JWU) held a ... academic center on Wednesday, April 22. , Johnson & Wales ... available by the re-alignment of Interstate-195. JWU’s new academic building, ... Chestnut streets in Providence, is scheduled to be completed in ... land the university purchased in 2012. , “It has long ...
(Date:5/4/2015)... Ana, CA (PRWEB) May 04, 2015 The ... live a full life are the motivating forces behind The ... California clinical psychologist and author Amy L. Stark. , The ... the little girl next door comes from Stark’s desire to ... Stark. “I’ve been a fairy godmother to my neighbors’ children ...
(Date:5/4/2015)... HOLLYWOOD, Calif. (PRWEB) May 04, 2015 ... program recognizes IPC clinical leaders who have made outstanding ... the patients they serve, both in acute and post-acute ... of the Year, Post-Acute Provider of the Year, Advanced ... Year and Specialist Provider of the Year. Recipients are ...
(Date:5/4/2015)... VA (PRWEB) May 04, 2015 Ticket Down ... at the John Paul Jones Arena in Charlottesville, VA. ... the history of the music business and this beloved performer ... Paul McCartney, the former member of two legendary groups: Wings ... in the music business since 2013 on the “Out There” ...
(Date:5/4/2015)... Diego, CA (PRWEB) May 04, 2015 ... a ribbon cutting ceremony at their brand new, 13,700 ... this year. The new building will not only provide ... population, but will also offer community and educational events ... The new facility is located next door to their ...
Breaking Medicine News(10 mins):Health News:Johnson & Wales University “Breaks Ground” On New $40 Million Engineering and Science Academic Center 2Health News:Johnson & Wales University “Breaks Ground” On New $40 Million Engineering and Science Academic Center 3Health News:Introducing New Children’s Book The Fairy Godmother Next Door 2Health News:IPC Healthcare Announces Clinicians of the Year 2Health News:IPC Healthcare Announces Clinicians of the Year 3Health News:Paul McCartney Tickets at John Paul Jones Arena in Charlottesville, VA: Ticket Down Slashes Paul McCartney Ticket Prices in Charlottesville at the John Paul Jones Arena 2Health News:San Diego Fertility Center Hosted a Ribbon Cutting Ceremony at Its New, Expanded Facility 2Health News:San Diego Fertility Center Hosted a Ribbon Cutting Ceremony at Its New, Expanded Facility 3
... Journal of the American College of Cardiology suggests that ... for the heart when delivered through a patch rather ... largest study of its kind, was cut short last ... Therapy (a combination of estrogen and progestin) increased the ...
... is a condition in which blood glucose levels are ... to energy. Food is broken down into a sugar ... cells throughout the body. Cells use the hormone insulin, ... glucose into energy. People with diabetes can prevent or ...
... with their physicians, can be an early warning sign ... hypertension, diabetes, high cholesterol, obesity and smoking are the ... that Erectile dysfunction affects 40 million men, yet just ... and doctors never ask.// ED is one symptom of ...
... of their children most expecting moms will do whatever needs to ... rest. But are those moms who smoke, ready to set ,aside ... willing to put their habit on ,hold for the sake of ... meeting of the Baxter County Tobacco Control Committee was ,that// Baxter ...
... country reported a new suspected case of the disease fears ... hours after doctors gave the cleared a woman suspected of ... worker was immediately admitted to a hospital after he arrived ... cough and cold similar to those of the deadly SARS ...
... the 2003 Annual Meeting of the American Association for Cancer ... effective means of cancer prognosis than measuring body mass index ... of the measures for detecting breast cancer are perfect, says ... ,But, he says that levels of leptin which ...
Cached Medicine News:
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: