Navigation Links
Sanofi and Regeneron Announce Publication of Positive Phase 2a Results of Dupilumab in Asthma in the New England Journal of Medicine
Date:5/21/2013

hase 2b studies in both asthma and atopic dermatitis shortly."

These data will be presented by Dr. Sally Wenzel this morning at the American Thoracic Society 2013 International Conference in a presentation entitled, "Efficacy and safety of SAR231893/REGN668 in patients with moderate-to-severe, persistent asthma and elevated eosinophil levels."

About IL-4R and the IL-4/IL-13 Pathway Atopic dermatitis and some types of asthma are characterized by the induction of a specific type of an immune response that is driven by a subset of immune cells called Type 2 helper T cells, or Th2 cells.  IL-4 and IL-13 are key cytokines that are required for the initiation and maintenance of this Th2 immune response.  IL-4 and IL-13 signaling occurs through Type I and II IL-4 receptors (IL-4 through both receptors and IL-13 through Type II receptors), which both contain a common IL-4R alpha subunit.

About Dupilumab (SAR231893/REGN668)Dupilumab is a fully human monoclonal antibody directed against IL-4R alpha and is administered via subcutaneous injection.  By blocking IL-4R alpha dupilumab modulates signaling of both IL-4 and IL-13, drivers of a Th2 immune response.  Dupilumab was created using Regeneron's pioneering VelocImmune® technology and is being co-developed with Sanofi.  Dupilumab is currently being studied in both atopic dermatitis and asthma.

About AsthmaAsthma is a chronic inflammatory disease of the airways characterized by airway sensitivity to environmental and biologic factors such as dust, chemicals, smoke, allergens, and viral infections leading to an acute and chronic narrowing of the airway and increased mucus production.  Patients with asthma can experience wheezing, shortness of breath, cough and chest tightness, and in severe cases, these symptoms can be life-threatening.  For most asthma patients, currently available treatments can control the disease.
'/>"/>

SOURCE Regeneron Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Sanofi Reports Positive Topline Results from Pivotal Phase III JAKARTA Study for JAK2 Inhibitor in Myelofibrosis
2. The Zacks Analyst Blog Highlights: Genomic Health, Sanofi, Regeneron Pharmaceuticals, Amgen and Isis Pharmaceuticals
3. Sanofi and Regeneron Announce Patient Enrollment in Two Phase 3 Trials with Sarilumab in Rheumatoid Arthritis (RA)
4. Tolero Pharmaceuticals announces Worldwide Agreement with Sanofi for the In-license of Alvocidib (Flavopiridol)
5. NextBio Announces Translational Medicine Partnership with Sanofi
6. Hemodialysis Patient Share for Sanofis Ferrlecit Increased Significantly in the First Quarter of 2013 Compared to the Previous Quarter
7. Sanofi US Offers a New Way to Say "Thank You" and Recognize the Unsung Heroes of Severe Allergy Awareness
8. Sanofi and Regeneron Report Positive Proof-of-Concept Data for Dupilumab, an IL-4R alpha Antibody, in Atopic Dermatitis
9. Sanofi New Drug Application for Lixisenatide Accepted for Review by FDA
10. Zacks Bull and Bear of the Day Highlights: Smithfield Foods, Logitech International, Sanofi, Isis Pharmaceuticals and Aegerion Pharmaceuticals
11. Sanofi Launches Breakthrough Technology for Cardiovascular and Vascular Surgery Procedures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... a privately-held medical products and technologies company, today announced ... Officer of the company, effective December 22, 2014. ... Board of Directors of ConvaTec thanks Mr. Berger for ... years," said Magnus Lundberg , the Chairman of ... company is well positioned for the future."  The company ...
(Date:12/22/2014)... STOCKHOLM , Dec. 22, 2014 ... Pharmaceuticals, Inc. today announced that the Committee for Medicinal ... Agency (EMA) has adopted a positive opinion for the ... of adult men with Peyronie,s disease with a palpable ... at the start of therapy. The use ...
(Date:12/22/2014)... , Dec. 22, 2014  Mark Farrah Associates ... providing a summary of the 2015 marketplace exchange ... trends.  According to a recent ... and Evaluation, Department of Health and Human Services) ... in individual medical plans through the Marketplace as ...
Breaking Medicine Technology:ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6Insights into the Marketplace and Individual Market Growth 2
... 2011 Codexis, Inc. (Nasdaq: CDXS ) today ... Crest Global Technology Leadership Forum, to be held in Vail, ... and Chief Financial Officer, will appear on a panel titled ... for August 8 at 12:30 p.m. ET. A webcast is ...
... BEIJING, July 14, 2011 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (Nasdaq: ... in China, announced today that it held its 2011 Annual ... Beijing Time. The required quorum, a majority of the common ... meeting was held concurrently at No. 39 Shangdi Xi Road, ...
Cached Medicine Technology:Sinovac Holds 2011 Annual Shareholders Meeting 2Sinovac Holds 2011 Annual Shareholders Meeting 3
(Date:12/26/2014)... 2014 India Network Foundation, a non-profit ... USA, announced today a new version of ā€œ EasySelect ... the right plan for their visiting parents. The technology ... the selection process when choosing an insurance plan by ... only a few clicks. Many elderly Asian Indian parents ...
(Date:12/25/2014)... This is a professional and in-depth study ... with a focus on the Chinese market. The report ... Sterilizers manufacturers and is a valuable source of guidance ... industry. This report provides a basic overview of the ... this part, the report presents the company profile, product ...
(Date:12/25/2014)... months the trends for evening dresses shift and ... of the hottest styles in the next few months.ā€ The ... 26 A-line sweetheart evening dresses, and announces the availability of ... trying our best to help a lady to show off ... prices, we provide discounted delivery costs to our customers worldwide. ...
(Date:12/25/2014)... December 25, 2014 BambooFlooringChina.com sells many ... quality bamboo flooring. Today, the company announces big ... many styles and colors. , BambooFlooringChina.com is the worldā€™s ... the promotion is valid until Jan. 20, 2015. , ... and woven with a natural thread. All the bamboo ...
(Date:12/25/2014)... (HealthDay News) -- The risk of burns from fires ... need to be extra cautious, an expert says. ... significant increase in patients coming in with burns," said ... Volunteer Firefighters Burn Center of Stony Brook University Hospital ... of joy, but if not careful, could quickly turn ...
Breaking Medicine News(10 mins):Health News:India Network Health Insurance Announces new Comprehensive Pre-existing Condition Coverage policy for Visitors to the United States 2Health News:India Network Health Insurance Announces new Comprehensive Pre-existing Condition Coverage policy for Visitors to the United States 3Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:Don't Let Burns Mar Your Holidays 2
... SilverStone ... and 10 at the Peabody Orlando in Orlando, Florida. In addition to hosting a ... also sponsoring the breakout session entitled "Managing Employee Injuries: Caring for Your Employees While ... ...
... ... whiskey to distributors, re-sellers, and customers. It was ultimately a lavish gift for an industry ... ... unveiled a custom made bottle of a well known whiskey, designed especially for their company. ...
... ... body sculpting. Surprisingly Zerona has also been clinically shown to reduce the resistance to ... Lipoprotein (LDL). , ... Houston, TX (PRWEB) April 6, 2010 -- A 22 participant pilot study revealed that ...
... over eight years of dietary data from more than 400,000 ... fruits and vegetables and a reduced risk of cancer is ... online April 6, 2010 in the Journal of the ... a diet rich in fruits and vegetables can reduce the ...
... Semel Institute for Neuroscience and Human Behavior at UCLA ... Reinvestment Act funds to establish a center dedicated to ... factors in neuropsychiatric and behavioral disorders. ... provide a dynamic environment for faculty and trainees engaged ...
... link is weak , TUESDAY, April 6 (HealthDay News) -- ... rich in fruits and vegetables helps protect against cancer. , ... women in 10 European countries and found only a weak ... cancer risk. , The study did find that heavy drinkers ...
Cached Medicine News:Health News:SilverStone Group to Attend Comfort Keepers Annual Conference in Orlando 2Health News:Sinrex Male Enhancement Manufacturer Gifts Custom Bottle of Whiskey to Customers 2Health News:"Zerona" Lipo-Laser Penetrates Wellness Industry for Anti-aging, Weight Loss, Body Sculpting and Cardiac Health 2Health News:"Zerona" Lipo-Laser Penetrates Wellness Industry for Anti-aging, Weight Loss, Body Sculpting and Cardiac Health 3Health News:Mount Sinai study finds only a weak link between fruit and vegetable and reduced risk of cancer 2Health News:Semel Institute awarded $15M to establish new integrative phenotyping center 2Health News:Fruits, Veggies Have Modest Effect on Cancer Risk 2
... therapeutic system is optimally ... in mind. As an ... ongoing therapy, SONOCUR Basic ... effective therapy. Plus, the ...
... not only one of the most modern lithotripters ... Apart from being designed for the treatment of ... tract, the MODULITH SLX can also be employed ... is equally suitable for the treatment of gallstones ...
... MODULITH SLK follows a completely new and revolutionary ... a wide energy range for all indications of ... articulated arm. Different components of the treatment set-up ... can be chosen from a variety of brands ...
The latex free, hydrophilic Self-Cath Plus is designed for single use, intermittent self-catheterization. The unique hydrophilic coating activates immediately upon exposure to water for fast, clean...
Medicine Products: