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Sanofi and Regeneron Announce Publication of Phase 2 Results with LDL Cholesterol-Lowering PCSK9 Antibody in the New England Journal of Medicine
Date:10/31/2012

-related.

This study was part of the Phase 2 program of SAR236553/REGN727, an investigational, subcutaneously administered, fully-human antibody targeting PCSK9 (proprotein convertase subtilisin/kexin type 9) that is currently being studied in the ODYSSEY Phase 3 trials for the lowering of low-density lipoprotein cholesterol (LDL-C).  Preclinical studies have shown that inhibiting PCSK9 leads to an increase in LDL receptors, which bind to LDL-C and clear it from the blood stream.  The publication can be accessed at http://www.nejm.org.

Additionally, new data from the Phase 2 studies of SAR236553/REGN727 will be presented at oral sessions at the American Heart Association's Scientific Sessions 2012 (AHA).  Results of these presentations are embargoed until the times listed below.  The presentations are:

Embargoed until November 6, 2012 at 9:30 AM PST:

  • Effect of SAR236553/REGN727 Fully Human Monoclonal Anti-Proprotein Convertase Subtilisin/Kexin Type 9 Antibody on Plasma Lipoprotein(a) Concentrations: Pooled Analysis from Three Phase 2 Studies.  Tuesday, November 6, 2012, 9:30-9:45 AM PST.  Presenter: Daniel Gaudet, M.D., Professor of Medicine, University of Montreal. [Abstract No. 14725]
  • Embargoed until November 6, 2012 at 4:45 PM PST :

  • Effect of REGN727/SAR236553 Anti-Proprotein Convertase Subtilisin/Kexin Type 9 Fully Human Monoclonal Antibody in Patients with Elevated Triglycerides/Low High-Density Lipoprotein Cholesterol: Data from Three Phase 2 Studies.  Tuesday, November 6, 2012, 4:45-5:00 PM PST.  Presenter: Robert Dufour, M.D., M.Sc., Associate Director, Institut de Recherches Cliniques de Montreal. [Abstract No. 16127]
  • About PCSK9
    PCSK9 is known to contribute to circulating LDL-C levels, as it binds to LDL receptors resulting in their degradation so that fewer are available on liver cells to remove LDL-C f
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    SOURCE Regeneron Pharmaceuticals, Inc.
    Copyright©2012 PR Newswire.
    All rights reserved

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