Navigation Links
Sanofi Reports Positive Topline Results from Pivotal Phase III JAKARTA Study for JAK2 Inhibitor in Myelofibrosis
Date:5/17/2013

ectable JAK2 or MPL mutations, yet do demonstrate dysregulated JAK2 signaling.

SAR302503 is a novel, investigational, JAK2 kinase inhibitor that selectively inhibits the JAK2 kinase, and in preclinical studies it has demonstrated activity against MF cells containing either JAK2V617F or MPLW515L mutation. As demonstrated in earlier Phase I and II studies, SAR302503 demonstrated activity in MF patients with both wild-type and mutated JAK2 (JAK2V617F). Another Phase II study in ruxolitinib-exposed patients who are either resistant or intolerant to ruxolitinib is ongoing.

About MyelofibrosisMyelofibrosis (MF) is a rare, but serious blood disease characterized by abnormal blood cell production and fibrosis (scarring) within the bone marrow. Scarring in the bone marrow interferes with blood cell production, and the spleen and liver compensate by producing and storing extra blood cells, which cause an enlarged spleen. Of the mutated JAK2‐associated myeloproliferative neoplasms, MF carries the poorest prognosis. Median survival for intermediate-2 and high-risk patients is approximately two and a half years; median survival for MF patients overall is approximately six years, and the 10 year risk of the disease transforming to fatal acute myelogenous leukemia (AML) is about 20%.[i]

The exact prevalence of MF is not known.  The latest research estimates that the prevalence of MF ranges from 4.2 to 5.6 per 100,000 people in the U.S., or approximately 15,000 patients.  Prevalence estimates in Europe are less clear.  People over age sixty are most likely to develop this disease, with men and women equally at risk.

About Sanofi Oncology Sanofi Oncology is a global division of Sanofi based in Cambridge, Massachusetts and Vitry, France.  At Sanofi Oncology, the patient is our inspiration. We are dedicated to translating science into effective therapeutics that address unmet med
'/>"/>

SOURCE Sanofi
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Sanofi Pasteur Presents Pediatric Data on Investigational Quadrivalent Influenza Vaccine
2. Sanofi US Launches Collaborate Activate Innovation Challenge
3. Sanofi Pasteur to add 2D barcode to six more vaccines
4. Sanofi and Regeneron Announce Publication of Phase 2 Results with LDL Cholesterol-Lowering PCSK9 Antibody in the New England Journal of Medicine
5. Sanofi and Regeneron Announce Patient Enrollment in Cardiovascular Outcomes Trial with Antibody to PCSK9 for Hypercholesterolemia
6. Sanofi and T1D Exchange to Launch Worldwide Study to Investigate Factors for Optimal Care for Young People with Diabetes
7. Sanofi Donates $500,000 to Hurricane Sandy for Immediate and Long-Term Relief Efforts
8. Phase II Trial of Sanofi JAK2 Inhibitor in Myelofibrosis Met Primary Endpoint
9. Sanofi Launches Breakthrough Technology for Cardiovascular and Vascular Surgery Procedures
10. Zacks Bull and Bear of the Day Highlights: Smithfield Foods, Logitech International, Sanofi, Isis Pharmaceuticals and Aegerion Pharmaceuticals
11. Sanofi New Drug Application for Lixisenatide Accepted for Review by FDA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... , June 30, 2015 Pulse Light ... a survey to Rosacea sufferers as part of their ongoing ... Rosacea sufferers found effective for their Rosacea. The survey participants ... comprised 47% men and 53% women. The results ... participants did not consider or attempt to visit their GP ...
(Date:6/30/2015)... , June 30, 2015  Ardelyx, Inc. (NASDAQ: ... cardio-renal, gastrointestinal and metabolic diseases, today announced that the ... 14, 2015, from 8:00 a.m.- 1:00 pm EDT in ... The Ardelyx senior management team will present an ... compound, tenapanor, which has completed Phase 2b clinical trials ...
(Date:6/30/2015)... , BERKELEY, Kalifornien, und KOPENHAGEN, Dänemark, ... Biologics, Inc. , ein Weltmarktführer der klinischen ... anderen therapeutischen Proteinen, gab heute bekannt, dass ... der Produktionskapazität den Ausbau der nordamerikanischen Produktionsanlage ... mit der Ergänzung  einer Einweg-Anlage Bioreactor 6Pack™ ...
Breaking Medicine Technology:84% of Rosacea Sufferers Say NHS Treatments Were "Ineffective" New Survey Reveals 284% of Rosacea Sufferers Say NHS Treatments Were "Ineffective" New Survey Reveals 3Ardelyx to Host Inaugural R&D Investor Day in New York City on July 14, 2015 2CMC Biologics baut GMP-Produktionskapazität in den USA aus 2CMC Biologics baut GMP-Produktionskapazität in den USA aus 3
... Mass., Oct. 26, 2011 Idenix Pharmaceuticals, Inc. (NASDAQ: ... financial results for the third quarter of 2011 on Wednesday, ... Idenix management will host a conference call at 4:30 p.m. ... financial results for the third quarter of 2011 and provide ...
... MECHANICSBURG, Pa., Oct. 26, 2011 One out of three ... according to an Opinion Research/Select Medical telephone poll. Against that ... a statement today reminding the American public that influenza season ... chronic lung disease such as asthma or COPD (Chronic Obstructive ...
Cached Medicine Technology:Idenix to Host Conference Call Discussing Third Quarter and Nine Month 2011 Financial Results and Announces Presentations at the American Association for the Study of Liver Diseases Meeting (AASLD) 2Poll: One Out of Three U.S. Adults Not Planning to Get Flu Shot This Year 2
(Date:6/30/2015)... ... June 30, 2015 , ... ... “Fireside Convalescent Care Center.” The video informs community members of Fireside’s Five-Star Medicare ... the need for those seeking care to be well informed and confident about ...
(Date:6/30/2015)... , ... June 30, 2015 , ... The LIV ... on fertility preservation and deciding the right age to pursue egg freezing. Statistics show ... the age of 35 — a 150 percent increase since the 1970s. , Sadly, ...
(Date:6/30/2015)... ... June 30, 2015 , ... Today, Grand Terrace Health Care ... Care Center.” Each year, Medicare ranks care centers around the country in an ... their needs. Grand Terrace prides itself on quality in each of Medicare’s evaluation ...
(Date:6/30/2015)... ... June 30, 2015 , ... According to a recent ... to 2013 while heroin-related deaths more than tripled in the same period—leading a majority ... Novus Medical Detox Center , a leading Florida-based drug treatment facility, asserts that these ...
(Date:6/30/2015)... , ... June 30, 2015 , ... ... announces today that they have been awarded the exclusive billing agreements with Jackson ... range of billing services encompassing their proprietary suite of billing process software functionality ...
Breaking Medicine News(10 mins):Health News:Fireside Convalescent Hospital Proves Itself as a Leading Care Center in New Video 2Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 2Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 3Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 4Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 5Health News:Grand Terrace Health Care Center Announces Five-Star Rating in YouTube Video 2Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 2Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 3Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 4Health News:ADVOCATE Wins Billing Agreements with Jackson Radiology Associates 2
... 1, 2010) Robotic surgical technology with its ... touch, even as they operate from a remote ... intersensory integration, and reports that surgical outcomes for ... compare favorably with traditional invasive surgery. Led by ...
... better than a "salt tax," study finds , MONDAY, ... to reduce U.S. sodium consumption by as little as ... of dollars, according to new research. , Cutting salt ... attacks and stroke. , "Per person on average it ...
... Mediterranean regimens all help the heart, study finds , ... three heart-healthy diets -- low-fat, low-carbohydrate, Mediterranean -- can ... to heart attack and stroke, an Israeli study indicates. ... though you experience only a moderate weight loss, if ...
... apt to enhance verbal skills, experts say, , MONDAY, ... their infants in front of supposedly brain-enhancing DVDs in ... be accomplishing nothing, new research shows. , What,s more, ... DVDs at an earlier age actually had lower levels ...
... , ... ... ... ...
... ... ... , , ... DALLAS , March ...
Cached Medicine News:Health News:Prostate cancer surgeons 'feel' with their eyes 2Health News:Prostate cancer surgeons 'feel' with their eyes 3Health News:Cutting Salt Could Prevent Almost 500,000 Heart Attacks 2Health News:Cutting Salt Could Prevent Almost 500,000 Heart Attacks 3Health News:Popular Diet Plans Can Unclog Arteries 2Health News:Watching Special Videos May Not Make Kids Brainier 2Health News:Watching Special Videos May Not Make Kids Brainier 3Health News:GNC Says 'Thank You' to Customers and Employees for Their $1.4 Million in Donations to the Sixth Annual St. Jude Children's Research Hospital(R) Thanks and Giving(R) Campaign 2Health News:GNC Says 'Thank You' to Customers and Employees for Their $1.4 Million in Donations to the Sixth Annual St. Jude Children's Research Hospital(R) Thanks and Giving(R) Campaign 3Health News:GNC Says 'Thank You' to Customers and Employees for Their $1.4 Million in Donations to the Sixth Annual St. Jude Children's Research Hospital(R) Thanks and Giving(R) Campaign 4Health News:GNC Says 'Thank You' to Customers and Employees for Their $1.4 Million in Donations to the Sixth Annual St. Jude Children's Research Hospital(R) Thanks and Giving(R) Campaign 5Health News:National Sleep Awareness Week(R) (March 7-13): How Are You Sleeping? 2Health News:National Sleep Awareness Week(R) (March 7-13): How Are You Sleeping? 3Health News:National Sleep Awareness Week(R) (March 7-13): How Are You Sleeping? 4Health News:National Sleep Awareness Week(R) (March 7-13): How Are You Sleeping? 5
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: