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Sanofi Pasteur Presents New Data Confirming Fluzone® High-Dose (Influenza Virus Vaccine) Produces Higher Antibody Response in the Age 65+ Population
Date:10/21/2011

SWIFTWATER, Pa., Oct. 21, 2011 /PRNewswire/ -- Sanofi Pasteur, the vaccines division of Sanofi (EURONEXT: SAN and NYSE: SNY), announced today data from a new study examining the immunogenicity and safety profiles of Fluzone High-Dose vaccine as compared with the responses of elderly and younger adults to a standard dose of Fluzone vaccine. The data were presented at the 49th Annual Meeting of the Infectious Diseases Society of America on October 21, 2011.

"The results further support the immunogenicity advantages of Fluzone High-Dose vaccine as compared to Fluzone vaccine, the standard dose comparator, in seniors 65 years of age and older," said Peter Tsang, M.D., Ph.D., Director Clinical Development, Sanofi Pasteur.

Fluzone High-Dose vaccine was licensed by the U.S. Food and Drug Administration (FDA) in December 2009 for adults 65 years of age and older. The vaccine was reviewed and licensed by the FDA via the accelerated approval pathway because the vaccine addressed an unmet medical need in the 65+ population. People over 65 years of age have the highest rates of hospitalization and death from influenza and its complications despite having among the highest immunization rates against influenza. As people age, the immune system typically weakens, and the body is less able to trigger an immune response to infection or vaccine. The immune response of people 65 years of age and older to the traditional flu shot is substantially lower than that of younger people. Thus, Fluzone High-Dose vaccine was developed to generate a more robust immune response in the senior population.  

Study DesignThe primary study objective was to describe post-vaccination immunogenicity of Fluzone High-Dose vaccine in the elderly and of Fluzone vaccine, the standard dose (SD), in the elderly and in younger adults as assessed by geometric mean titers (GMTs) and seroconvers
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