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Sanofi Pasteur Global Dengue Vaccine Clinical Program Expanded in Latin America
Date:12/9/2009

n epidemiological alert as dengue continues to circulate in Latin America", said Dr. Jorge Mendez, Investigator at the children's hospital Federico Gomez in Mexico and co-investigator for the evaluation of a dengue vaccine in Mexico. "Clinical studies in Mexico are critical steps to advance the development of a vaccine for the prevention of dengue. We are happy that Mexico contributes to scientific research that would benefit the entire region."

"Most of the severe dengue cases are among children under the age of 15 years old. It is an important cause of hospitalization which contributes highly to the burden of disease and increases costs for our health system," said Dr. Diana Patricia Rojas Alvarez, Expert for vector born diseases, dengue and yellow fever, at the National Institute of Health in Colombia. "A safe and effective vaccine for children is much needed and we are pleased to support pediatric clinical studies in Colombia."

Sanofi Pasteur global clinical study program for a dengue vaccine

Sanofi Pasteur started the development of a dengue vaccine in the '90s. Clinical studies with its most advanced tetravalent candidate vaccine started in the 2000s. Sanofi Pasteur's dengue vaccine candidate has been evaluated in clinical trials (Phase I, II) in adults and children from non-endemic (U.S.) and endemic countries (Mexico, Philippines). Overall, a balanced immune response against all four serotypes was observed after three doses of the vaccine. The vaccine appears to be well tolerated with a similar safety profile after each dose [2].

Sanofi Pasteur's dengue vaccine research program includes ongoing clinical studies with adults and children in Mexico, Colombia, Honduras, Puerto Rico, Peru, the Philippines, Vietnam, Singapore, and Thailand. These studies follow the highest standards from the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Hum
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