Navigation Links
Sanofi Aventis: Study Shows Otamixaban Substantially Reduced Complications of Invasive Management of Acute Coronary Syndromes
Date:8/31/2009

II SEPIA-ACS1/ TIMI-42 study randomized 3241 patients from 36 countries in 6 treatment arms. The study assessed the efficacy and safety of five different doses of otamixaban versus the standard unfractionated heparin plus Glycoprotein IIb/IIIa inhibitor (eptifibatide), on background of standard dual antiplatelet therapy, in patients with high-risk non-ST-elevation acute coronary syndromes. SEPIA-ACS1 study showed that otamixaban displayed clinically meaningful activity on the primary endpoint from the threshold dose of 0.070 mg/kg/h, the second tested dose, with a consistent antithrombotic effect up to the 5th highest tested dosage. The lowest studied dosage was prematurely stopped due to insufficient activity, based on recommendation by an independent data monitoring board. Moreover a combined analysis of the intermediate doses (0.105 and 0.140 mg/kg/h) of otamixaban arms showed that otamixaban reduced by approximately 46 percent (p=0.0198) the risk of the composite of death or a second myocardial infarction, a predefined study secondary efficacy endpoint.

The potent antithrombotic effect of otamixaban was also accompanied with a dose-dependent bleeding profile. Combined intermediate otamixaban dosages showed a safety profile not statistically different with regard to TIMI major or minor bleeding through 7 days, in comparison to UFH and GPIIb/IIIa inhibitor comparator (RR 1.20, 95% CI 0.64-2.27, p=0.5634).

'The SEPIA-ACS1 trial is providing very encouraging results for a new and more effective treatment approach', said Marc Cluzel, MD Senior Vice President Research and Development sanofi-aventis. 'We aim, on the basis of these findings to address through our development program remaining patients', practionners' and payers' needs for management of ACS.'

Acute Coronary Syndromes is a general term used to regroup clinical symptoms related to acute myocardial ischemia. ACS represents an area of importa
'/>"/>

SOURCE Sanofi-aventis
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Sanofi Pasteur Submits Supplemental Application for A(H1N1) Pandemic Vaccine to U.S. FDA
2. Sanofi-aventis Stands Behind the Safety of Lantus(R)
3. Sanofi Pasteur Dengue Vaccine Enters Pediatric Efficacy Clinical Study
4. Sanofi Pasteur Starts a Phase II Study of a Vaccine Against Clostridium Difficile
5. Sanofi Aventis: People With Type 2 Diabetes Treated With LANTUS(R) and APIDRA(R) Achieved Greater Reductions in A1C Than Those Treated With Pre-mixed Insulin
6. Insulin Analogues From Novo Nordisk, Eli Lilly and Sanofi-Aventis Will Drive Growth in the Type 1 Diabetes Drug Market
7. Sanofi Pasteur Shipping First Doses of Influenza Vaccine for the 2008-2009 Season in the US
8. Sanofi Pasteur to Donate 60 Million Doses of H5N1 Vaccine to WHO Over 3 Years for its Influenza Vaccine Global Stockpile
9. Sanofi Pasteur Initiates Phase II Trial of Cell Culture-Based Seasonal Influenza Vaccine
10. Sanofi Pasteur Receives FDA Approval of Meningococcal Vaccine for Children
11. Vical Licensee Sanofi-aventis Initiates Phase 3 Trial to Reduce Amputations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... 2014 CVS Caremark Corporation (NYSE: CVS ... and consideration payable in connection with its previously announced cash ... for (1) any and all of its 6.250% Senior Notes ... to a maximum amount of its 6.125% Senior Notes due ... due 2017 (collectively, the "Maximum Tender Offer Notes" and together ...
(Date:8/21/2014)... Mass. , Aug. 21, 2014   ... AEX: PHIA) today announced it has received 510(k) ... to market its precision planning application for Transcatheter ... Philips TAVI application provides interventionalists with pre-procedural, high-precision ... The Philips TAVI planning application is available as ...
(Date:8/21/2014)... CHESTERBROOK, Pa. , Aug. 21, 2014 /PRNewswire/ ... AUXL ), a specialty biopharmaceutical company, today announced ... study of collagenase clostridium histolyticum (or CCH) for ... known as cellulite. In the Phase 2a trial, ... (0.48mg) and high (0.84mg)) showed an improvement in ...
Breaking Medicine Technology:CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 2CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 3CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 4CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 5CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 6Philips receives FDA 510(k) Clearance for TAVI Precision Treatment Planning Application 2Philips receives FDA 510(k) Clearance for TAVI Precision Treatment Planning Application 3Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 2Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 3Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 4Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 5Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 6Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 7
... Wash., Nov. 9 Cardiac Science Corporation ... external defibrillator ( AED ) and diagnostic cardiac ... third quarter ended September 30, 2009, in line with its ... million for an AED field product update and a non-cash ...
... Nov. 9 Hill-Rom (NYSE: HRC ) ... venture that will focus on the sale and distribution of ... to be sold separate from a bed frame and as ... end of their useful life. Hill-Rom, a global leader ...
Cached Medicine Technology:Cardiac Science Announces Third Quarter Results 2Cardiac Science Announces Third Quarter Results 3Cardiac Science Announces Third Quarter Results 4Cardiac Science Announces Third Quarter Results 5Cardiac Science Announces Third Quarter Results 6Cardiac Science Announces Third Quarter Results 7Cardiac Science Announces Third Quarter Results 8Cardiac Science Announces Third Quarter Results 9Cardiac Science Announces Third Quarter Results 10Cardiac Science Announces Third Quarter Results 11Cardiac Science Announces Third Quarter Results 12Cardiac Science Announces Third Quarter Results 13Cardiac Science Announces Third Quarter Results 14Cardiac Science Announces Third Quarter Results 15Cardiac Science Announces Third Quarter Results 16Cardiac Science Announces Third Quarter Results 17Cardiac Science Announces Third Quarter Results 18Cardiac Science Announces Third Quarter Results 19Cardiac Science Announces Third Quarter Results 20Hill-Rom and Encompass Group Form Joint Venture 2Hill-Rom and Encompass Group Form Joint Venture 3Hill-Rom and Encompass Group Form Joint Venture 4Hill-Rom and Encompass Group Form Joint Venture 5
(Date:8/21/2014)... August 21, 2014 The costs paid by ... to rise, according to insurer data. The Quotes Pros company ... real time using its tools at http://quotespros.com . ... company homepage connects with providers offering multiple coverage packages for ... promoted to the public are now easier to compare using ...
(Date:8/21/2014)... BambooIndustry.com is an internationally well-known supplier and leader in ... new collection of elegant bamboo floorings . These ... looking for high quality floorings for their own houses. ... (up to 29 percent off). Before the end of ... , The company’s bamboo flooring products are made using ...
(Date:8/21/2014)... 2014 Recently, Van Uden Center ... Alternative medicine is on the rise and much ... to The Fiscal Times, young people are becoming ... medicine. , The Fiscal Times published an article ... embracing alternative medicine. The article can be found ...
(Date:8/21/2014)... Line: Patients with advanced laryngeal cancer appear to ... surgery than nonsurgical chemoradiation. , Author: Uchechukwu C. ... Medicine at Mount Sinai, New York, and colleagues. ... laryngeal cancer are diagnosed each year and squamous ... these tumors. Prior to 1991, total surgical removal ...
(Date:8/21/2014)... source of fungal infections that have been sickening HIV/AIDS ... on trees. , The discovery is based on the ... summer gathering soil and tree samples from areas around ... named Cryptococcus gattii (CRIP-to-cock-us GAT-ee-eye). ... species including C. gattii , causes life-threatening infections ...
Breaking Medicine News(10 mins):Health News:Dental Insurance Now Quoted for Families Online at Insurer Portal 2Health News:Buy Elegant Bamboo Floorings from Internationally Well-known Supplier BambooIndustry.com 2Health News:Van Uden Center Sees Growth in Alternative Medicine 2Health News:Surgery associated with better survival for patients with advanced laryngeal cancer 2Health News:Fungus deadly to AIDS patients found to grow on trees 2
... major changes in their lives and cooperate with public health ... according to the latest national survey // conducted by the ... and Biological Security. ,However, the survey also finds that ... care for them if they become ill or would face ...
... possession of child pornography material a federal crime is forcing ... or become one based on the child pornography being present ... are going to court and attorneys are calling us, wanting ... porn on their computer," said Dr. Humberto Temporini, a forensic ...
... after two minors died minutes after receiving an injection ... Chhattisgarh. ,Two brothers, Umashanker, 6 years, and Gaurishankar, ... injections for treatment of fever, cough and cold Friday ... of the same family, who were also given injections ...
... Eating Disorders, an international organization for eating disorder treatment, ... on the use of severely underweight models in fashion ... to adopt a minimum acceptable height-to-weight ratio in keeping ... ,“The unprecedented move of a major fashion ...
... confirmed that women who thrive on a diet which is rich ... like //which is highly refined energy food gain more weight and ... a diet rich in fiber and complex carbohydrates. ,Highly refined ... circulating sugar in the body in a sudden surge which is ...
... yesterday looks into support props for care givers of mentally ... relatives // and caregivers of mentally sick people in Ireland.Very ... sick goes beyond the realms of hospital in –patient care. ... by other care givers, often family members of the mentally ...
Cached Medicine News:Health News:Fears of Pandemic Flu makes Americans Ready for Change 2Health News:Fears of Pandemic Flu makes Americans Ready for Change 3Health News:Fears of Pandemic Flu makes Americans Ready for Change 4Health News:Fears of Pandemic Flu makes Americans Ready for Change 5Health News:Fears of Pandemic Flu makes Americans Ready for Change 6Health News:Does Child pornography lead to Child abuse? 2Health News:Does Child pornography lead to Child abuse? 3Health News:Academy for Eating Disorders Calls for Ban on Underweight Models 2
Triangle shape (3.0mm long) Tip with Sliding Inner Shaft, Squeeze Activates Shaft to Punch; overall length 130mm, in stainless steel...
Very fine, blunt tip....
... e.cam single-detector system offers general ... access for gurneys and wheelchairs. ... clinically versatile open gantry, caudal/cephalic ... contouring for SPECT and whole ...
Sharp diamond shaped double blade in stainless steel....
Medicine Products: