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Sanofi Aventis: People With Type 2 Diabetes Treated With LANTUS(R) and APIDRA(R) Achieved Greater Reductions in A1C Than Those Treated With Pre-mixed Insulin
Date:9/10/2008

% male, 59% Caucasian, and 38% African-American, duration of diabetes 13 years, A1C 9.25%, and BMI 35.8 kg/m2. During the 4 months before randomization, 88% used insulin with a mean daily dose of 71IU, about 70% of patients used oral hypoglycemic agent(s) and 29% had chart records for hypoglycemia. Mean follow-up time was 179 days. One patient (1%) randomized to the LANTUS(R)/APIDRA(R) treatment therapy switched to the pre-mixed insulin therapy, relative to 9 (10%) randomized to pre-mixed switched to the LANTUS(R)/APIDRA(R) treatment therapy.

Additional study findings showed that mean number of concomitant oral diabetes agents were 0.86 versus 1.14 (d=-0.28, p=0.041). Total daily insulin dose was 78IU versus 90IU, respectively (p=0.232) For each additional 1% A1C reduction during the approximately 6 months follow-up period, the medication cost for the LANTUS(R)/APIDRA(R) arm was $841 versus $1,308 for the pre-mixed insulin arm.

Additional details about the GINGER and LACE data are included in the study abstracts, available at EASD.org.

You will find the full information about LANTUS(R), APIDRA(R) and diabetes in the complete text of the Press Release on site:

http://en.sanofi-aventis.com/press/press_releases/2008/news_list_2008.a sp

About sanofi-aventis

Sanofi-aventis, a leading global pharmaceutical company, discovers, develops and distributes therapeutic solutions to improve the lives of everyone. Sanofi-aventis is listed in Paris (EURONEXT : SAN) and in New York (NYSE : SNY).


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