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Sanofi Announces Positive Phase 3 Data for Once-Daily Lixisenatide for Type 2 Diabetes
Date:6/22/2013

the U.S."

The study findings are highlighted at the American Diabetes Association Scientific Sessions in the following abstract: Once-Daily Lixisenatide As Add-On to Basal Insulin ± OADs in Patients with Type 2 Diabetes Selectively Reduces Postprandial Hyperglycemic Daytime Exposure (Riddle et al.) [Abstract No. 2013-A-4270, Poster Presentation on Saturday, June 22, 11:30 a.m. to 1:30 p.m. CDT].

About Lixisenatide
Lixisenatide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) for the treatment of patients with type 2 diabetes mellitus. GLP-1 is a naturally-occurring peptide hormone that is released within minutes after eating a meal. It is known to suppress glucagon secretion from pancreatic alpha cells and stimulate glucose-dependent insulin secretion by pancreatic beta cells.

Lixisenatide was in-licensed from Zealand Pharma A/S (NASDAQ OMX Copenhagen: ZEAL), www.zealandpharma.com, and is approved in Europe for the treatment of adults with type 2 diabetes mellitus to achieve glycemic control in combination with oral glucose-lowering medicinal products and/or basal insulin when these, together with diet and exercise, do not provide adequate glycemic control. Lixisenatide is also approved in Mexico and Australia for the treatment of adults with type 2 diabetes. Lixisenatide is currently under review by the U.S. Food and Drug Administration after the acceptance of the New Drug Application (NDA) submission for lixisenatide in February 2013. Lyxumia® is the proprietary name approved by the European Medicines Agency (EMA), Australia and Mexico, and submitted to other health authorities for the GLP-1 RA lixisenatide. The proprietary name for lixisenatide in the United States is under consideration.

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