Navigation Links
Sanifit Announces Enrollment of First Patient in CaLIPSO - a Phase IIb Study for the Treatment of Cardiovascular Calcification in End-Stage-Renal-Disease Patients on Haemodialsis
Date:1/23/2017

SAN DIEGO and PALMA, Spain, January 23, 2017 /PRNewswire/ --

Laboratoris Sanifit S.L., a clinical-stage biopharmaceutical company focused on treatments for calcification disorders, today announced that the first patient has been enrolled in the Phase IIb "CaLIPSO Study" clinical trial of lead candidate, SNF472, for the treatment of cardiovascular calcification (CVC) in end-stage-renal-disease (ESRD) patients on haemodialysis (HD).

Most ESRD patients, in the last stage of chronic kidney disease, suffer from accelerated cardiovascular calcification, which correlates with higher cardiovascular risk. Cardiovascular disease is the most common cause of death in patients with ESRD and there are currently no approved therapies for the treatment of CVC. SNF472 is being developed to address this significant medical challenge.

The CaLIPSO Study is a 52-week, double-blind, randomized, placebo-controlled trial which will evaluate the effects of 300 and 600mg of SNF472 on the progression of cardiovascular calcification (CVC). The study will be conducted at approximately 75 investigation sites across the US, Spain, Italy and the UK. It is the largest trial ever in the field of cardiovascular calcification with plans to enrol 400 patients and results expected in 2019.

Joan Perelló, CEO of Sanifit, said: "SNF472 selectively blocks the pathological cardiovascular calcification progression and we are delighted to initiate this trial. We believe SNF472 has significant potential as a novel treatment of cardiovascular calcification for ESRD patients suffering from this life-threatening clinical condition. We have assembled a strong management team and look forward to progressing the development of our lead compound for this high unmet medical need."

Sanifit has also initiated a Phase II clinical trial to evaluate SNF472 for the treatment of calciphylaxis, the most severe form of cardiovascular calcification. SNF472 has received orphan drug designation from both the EMA in June 2012 and the FDA in December 2012.

For media enquiries: 

Sanifit 
Joan Perelló
CEO Sanifit

Hume Brophy 
Conor Griffin, Alex Protsenko, Alexia Faure
Tel: +44 (0) 20 7862 6475
Email: sanifit@humebrophy.com

About SNF472 

SNF472 is an intravenous formulation with a novel mechanism of action for haemodialysis patients with cardiovascular diseases linked to calcification. SNF472 is being developed for two indications: reduction of cardiovascular events in dialysis patients and for the treatment of calciphylaxis. SNF472 has orphan drug status for the treatment of calciphylaxis from both the EMA and FDA. SNF472 selectively blocks the pathological cardiovascular calcification progression and poses an innovative solution for these unmet medical needs.

About Sanifit  

Sanifit is a biopharmaceutical company focused on the development of SNF472. The company was founded in 2007 as a spin-off of the University of the Balearic Islands and expanded its activities in the USA in 2016 with the incorporation of a subsidiary with offices in San Diego. SNF472 is an experimental drug for the treatment of cardiovascular diseases linked to calcification in the End Stage Renal Disease population undergoing haemodialysis. Sanifit has completed Phase I studies with healthy volunteers and haemodialysis patients, and after a recent series C funding round of $41.3M (€36.6M), Sanifit has launched two Phase II programs in ESRD and in the orphan space in calciphylaxis. For more information please visit www.sanifit.com



'/>"/>
SOURCE Laboratoris Sanifit S.L.
Copyright©2017 PR Newswire.
All rights reserved


Related medicine technology :

1. Ethicon Announces Acquisition of Megadyne Medical Products, Inc.
2. Wells Specialty Pharmacy Announces the Merger of Its Acquisitions and the Appointment of a New President
3. Stealth BioTherapeutics Announces New Appointments to Senior Leadership Team
4. Milner Therapeutics Institute Announces New Partnership with US Pharmaceutical Company Pfizer
5. EnteroMedics Announces Pricing of $16.5 Million Underwritten Public Offering
6. Spotlight Innovation Subsidiary Caretta Therapeutics Announces Venodol, a New Over-the-counter Product to Treat Chronic Pain
7. Dermata Therapeutics, LLC Announces Initiation of Treatment in a Phase 2 Acne Rosacea Clinical Study
8. Invetech Announces Agreement with Erytech to Develop Scalable Automated Manufacturing System
9. Astellas Announces Participation in Access Accelerated
10. Jazz Pharmaceuticals Announces First Patient Enrolled in Phase 3 Clinical Trial Evaluating Defibrotide for the Potential Prevention of VOD in High Risk Patients
11. SHAREHOLDER ALERT: Bronstein, Gewirtz & Grossman, LLC Announces Investigation of Anthera Pharmaceuticals, Inc. (ANTH)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2017)... plc (NASDAQ: ENDP ) will announce its second-quarter 2017 ... management team will host a conference call and webcast before the ... The dial-in number to access the call is U.S./ Canada ... 45397076. Please dial in 10 minutes prior to the scheduled start ... the call will be available from August 8, 2017 at 11:30 ...
(Date:7/13/2017)... July 13, 2017 RK Logistics Group, Inc. was ... certification for its Fremont, CA headquarters ... the Tri-Valley and San Jose for ... of Fremont , with its Fremont Innovation District, is ... such a powerful resource to the hundreds of biotech, pharma ...
(Date:7/12/2017)... Lilly and Company (NYSE: LLY ) has entered ... patent litigation in the U.S. District Court for the Eastern ... ® (tadalafil) unit dose patent. This patent was previously ... the agreement, Cialis exclusivity is now expected to end at ... dose patent for Cialis is valid and infringed by companies ...
Breaking Medicine Technology:
(Date:7/24/2017)... , ... July 24, 2017 , ... A CDC study shows that, although people are ... Caucasians (ages 18 to 29), had at least one case of sunburn within the past ... which causes people to ignore the issue. However, only recently have people become conscientious of ...
(Date:7/24/2017)... ... July 24, 2017 , ... The 2017 NCSL International Workshop ... theme focuses on the new ISO/IEC 17025 standards. This marks the first time ... and calibration will be changed. , As an exhibitor, METTLER TOLEDO will ...
(Date:7/24/2017)... ... July 24, 2017 , ... Paul Vitenas, MD, FACS is excited ... plastic surgeons, invited to attend Allergan’s recent meeting with their Plastics Advisory Board. As ... the world, Allergan is bringing a newly defined structure to the aesthetics market. ...
(Date:7/24/2017)... , ... July 24, 2017 , ... ... CURE announced that they have enrolled over 100,000 children in their treatment program. ... born every year in areas where treatment is limited or non-existent. Without intervention, ...
(Date:7/24/2017)... Church, VA (PRWEB) , ... July 24, 2017 ... ... figuring out how to change manufacturers future. , The agency is hammering out ... Cures Act, one of the farthest-ranging laws ever to affect FDA-regulated firms. The ...
Breaking Medicine News(10 mins):