Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of 'Knock-Out' ...(Sigma-Aldrich's Research Biotech Unit. ...),Health

Date:3/24/2008

Sigma-Aldrich's Research Biotech Unit. "In addition to reagents for knocking out an investigator's 'favorite gene' in a particular cell type, the ZFN platform can be used to generate panels of cell lines for small molecule drug screening in which the 'druggable universe' of gene targets have been individually knocked out. We expect to have ZFN research reagents similar to those used in this publication available to all research scientists in the very near future."

"The applications of this technology are of significant commercial value," said Edward Lanphier, Sangamo's president and CEO. "While the current publication focuses on research and biotechnology applications, we have used these same techniques for knocking out genes in multiple crop plants and to develop ZFP Therapeutics(TM). We are developing potential treatments for HIV/AIDS by knocking-out the CCR5 gene in T-cells and for brain cancer (glioblastoma) by disrupting the glucocorticoid receptor (GR) in engineered killer T-cells. We expect to file Investigative New Drug Applications (INDs) for both of these programs to enter the clinic later this year."

About Sigma-Aldrich

Sigma-Aldrich is a leading Life Science and High Technology company. Our biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical and other high technology manufacturing. We have customers in life science companies, university and government institutions, hospitals, and in industry. Over one million scientists and technologists use its products. Sigma-Aldrich operates in 36 countries and has 7,900 employees providing excellent service worldwide. We are committed to Accelerating Customer Success through Leadership in Life Science, High Technology and Service. For more information about Sigma-Aldrich, please visit our award-winning Web site at

SOURCE Sangamo BioSciences, Inc. Copyright©2008 PR Newswire. All rights reserved

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