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Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of 'Knock-Out' Cell Lines
Date:3/24/2008

ZFN Technology has Broad Applications in Research, Drug Development and

Therapeutics

ST. LOUIS and RICHMOND, Calif., March 24 /PRNewswire-FirstCall/ -- Sigma-Aldrich Corporation (Nasdaq: SIAL) and Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today the publication of data demonstrating the use of Sangamo's zinc finger DNA-binding protein nucleases (ZFNs(TM)) in a new approach for rapid generation of "knock-out" cell lines, important tools in research and therapeutic product development.

This work, which was carried out in collaboration with scientists from Pfizer Inc, represents a significant advance in the specificity and efficiency of the generation of cell lines in which an individual gene has been "knocked-out" or deleted. Such cell lines are powerful tools that are widely used in research to identify a gene's function, in drug development to screen potential drug candidates and for production of recombinant proteins. In addition, Sangamo is using this technology to develop ZFP Therapeutics(TM) for the treatment of HIV/AIDS and brain cancer. Sigma-Aldrich is Sangamo's exclusive licensee for this technology in the laboratory research reagent field.

"These data have broad implications for experimental and translational biology, biotechnology and medicine," said Philip Gregory, D.Phil., Sangamo's vice president of research. "The generation of knockouts in basic research and industrial cell line engineering has been severely limited by the absence of efficient
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SOURCE Sangamo BioSciences, Inc.
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