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Sangamo BioSciences Presents Clinical Data From SB-728-T HIV Study Demonstrating Long-Term Immune Reconstitution and Reduction in the HIV DNA Reservoir In Subjects with Long-Term Infection
Date:11/4/2013

RICHMOND, Calif., Nov. 4, 2013 /PRNewswire/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today the presentation of clinical data from its program to develop a ZFP Therapeutic® for HIV/AIDS.  The data demonstrate a reduction in the HIV DNA reservoir since receiving SB-728-T in seven of nine HIV-infected subjects on long-term anti-retroviral therapy (ART), despite a median duration of HIV infection of 21 years and baseline CD4 T-cell counts prior to SB-728-T treatment of <500 cells/µl. The data were presented  at a translational medicine meeting organized by The Lancet and Cell publications and entitled, "What Will it Take to Achieve an AIDS-Free World?" which is being held in San Francisco, November 3-5, 2013.

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"These data are very promising and demonstrate the important link between SB-728-T treatment and immune reconstitution of central memory and total CD4 T cells and lower HIV DNA levels in subjects at 12 months," said Rafick-Pierre Sekaly, Ph.D., Co-Director & Chief Scientific Officer, The Vaccine & Gene Therapy Institute of Florida (VGTI Florida), who presented the data and whose laboratory carried out the immunologic analyses.

ART successfully suppresses viral load in most subjects, but a significant proportion, so called immunologic non-responders (INR), do not restore normal CD4 counts above 500 cells/µl.  HIV-infected subjects who were classified as INR, enrolled in Sangamo's ongoing SB-728-902 clinical trial (Cohorts 1-3), received a single infusion of SB-728-T which resulted in a durable increase in total CD4 T-cells associated wi
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