Navigation Links
Sangamo BioSciences Presents Clinical Data From Key SB-728-T HIV Studies: Proof Of Concept For Ongoing Sustained Functional Control Of HIV Viral Load; Cytoxan Preconditioning Successfully Enhances Engraftment
Date:12/6/2013

m2.

The viral reservoir is a source of chronic HIV infection that is not addressed by current ART. All nine subjects enrolled in Sangamo's Phase 1 study (SB-728-902 Cohorts1-3) experienced a long term reduction  in the reservoir over three years, as measured by HIV DNA in peripheral blood mononuclear cells (median 0.9 log decrease at Month 36).  In addition, a reduction in the viral reservoir, as measured by integrated HIV DNA in sorted CD4 cells, correlated with increased numbers of functional HIV gag-responsive CD8 T-cells, suggesting that these cells can mount  an anti-HIV response with the help of  ZFN modified CD4 T-cells (SB-728-T).

Collectively, data from clinical studies demonstrate that in all trial subjects, SB-728-T treatment results in a durable increase in total CD4 T-cells and sustained levels of SB-728-T which correlate with ZFN-modification of long lived central memory and memory stem cell subsets. Data from immunological analyses of subjects in both Phase 1 and Phase 2 studies of SB-728-T suggest that certain cell surface marker and gene expression profiles may predict which patients will likely respond best to SB-728-T treatment.

"We are very encouraged by our data to date and by our continued progress in understanding the factors required to maximize the potential of this novel immunologic approach to functional control of HIV," said Edward Lanphier, Sangamo's president and CEO. "We look forward to continuing to update on our progress in the coming months as we complete treatment in our expanded SB-728-1101 study. We will also present preclinical data from several of Sangamo's programs in monogenic diseases and other indications at the upcoming Annual Meeting of the American Society of Hematology (ASH)."

Summary of Clinical Trial Design
About SB-728-902
Cohorts 1-3
The study is an open-label Phase 1 clinical trial to evaluate the safety and tolerabi
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Sangamo BioSciences Reports Second Quarter 2012 Financial Results
2. Sangamo BioSciences to Webcast Analyst Briefing on Thursday, December 6, 2012
3. Sangamo BioSciences Reports Fourth Quarter And Full Year 2012 Financial Results
4. Sangamo BioSciences Announces Presentation At 33rd Annual Cowen And Company Health Care Conference
5. Sangamo BioSciences Announces Presentation At The Barclays Global Healthcare Conference
6. Sangamo BioSciences Announces First Quarter 2013 Conference Call and Webcast
7. Sangamo BioSciences Reports First Quarter 2013 Financial Results
8. Sangamo BioSciences Announces Second Quarter 2013 Conference Call And Webcast
9. Sangamo BioSciences Announces Publication of First Demonstration of Inactivation of Extra Chromosome Responsible for Down Syndrome
10. Sangamo BioSciences Reports Second Quarter 2013 Financial Results
11. Sangamo BioSciences Announces Notice Of Allowance For New Patent Application Covering Genome Modification Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... July 22, 2014 /PRNewswire-iReach/ -- Reproductive Medicine Associates ... York ), a nationally and internationally-recognized leader in ... reproductive assistance, is pleased to announce a new collaboration ... Care Programs to recognize the sacrifices made by veterans ... Compassionate Corps Program will allow qualifying veterans and the ...
(Date:7/22/2014)... 22, 2014 WuXi PharmaTech (Cayman) Inc. (NYSE: ... R&D outsourcing company with operations in China ... announced that it will release financial results for the second ... on Wednesday, August 13, 2014 (which will be Thursday morning, ... available on the investor relations section of the Company,s website ...
(Date:7/22/2014)... SOUTH EASTON, Mass. , July 22, ... ("PBI" or the "Company") and Parabase Genomics ... have entered into a strategic research and ... of the collaboration, PBI will develop a ... neonatal molecular diagnostics and newborn confirmatory testing ...
Breaking Medicine Technology:Reproductive Medicine Associates of New York Collaborates with EMD Serono to Offer Treatment Assistance to Eligible Veterans and their Spouses 2Reproductive Medicine Associates of New York Collaborates with EMD Serono to Offer Treatment Assistance to Eligible Veterans and their Spouses 3WuXi PharmaTech Schedules Second-Quarter 2014 Earnings Release 2Pressure BioSciences to Develop Front-end Sample Preparation for Parabase Genomics' Targeted Next Generation Sequencing Testing Platform 2Pressure BioSciences to Develop Front-end Sample Preparation for Parabase Genomics' Targeted Next Generation Sequencing Testing Platform 3Pressure BioSciences to Develop Front-end Sample Preparation for Parabase Genomics' Targeted Next Generation Sequencing Testing Platform 4
... is making it easy and affordable for customers to stay ... in August, flu vaccines will be administered by Ralphs Pharmacies, ... in-store pharmacies Ralphs operates throughout Southern California This ... shot for everyone over the age of six months. The ...
... the Laboratory to the Reality of Daily Life -- DUDERSTADT, Germany, August 30, 2010 ... ... ... var first_result; // Results are keyed by longUrl, so we need to grab the first one. for ...
Cached Medicine Technology:From the Laboratory to the Reality of Daily Life 2From the Laboratory to the Reality of Daily Life 3From the Laboratory to the Reality of Daily Life 4From the Laboratory to the Reality of Daily Life 5From the Laboratory to the Reality of Daily Life 6
(Date:7/22/2014)... 22, 2014 As one alternative to ... to buy can now reduce or in some cases ... released its cosmetic buying guide to help buyers find ... http://cherrynews.com/best-nourishing-eye-serum . , This guide is meant for both ... different under eye circles that can appear. While some ...
(Date:7/22/2014)... Africa (PRWEB) July 23, 2014 It all ... in an attempt to find common ground. Willem de Liefde ... the crossroads of their lives or careers. , Willem wrote ... deeper and look beyond the surface of things. It is ... future, driven by care and commitment. , This book represents ...
(Date:7/22/2014)... Obtaining a bachelor’s degree in nursing ... have hands-on medical experience. The School of Nursing at ... the launch of an accelerated nursing degree program that ... program, the UNCG Veterans Access Program (VAP), will start ... With some prior college credit, veterans who are RNs ...
(Date:7/22/2014)... Dr. Dental is excited to announce the redesign ... in mind, one of the main differences from the old ... navigation very easy. Dr. Dental is renowned for having exceptional ... dentist affordable, convenient and fun, and the new website mirrors ... appointment scheduling system right on the home page where a ...
(Date:7/22/2014)... United Benefit Advisors (UBA), the nation's leading ... an insurance veteran with more than 15 years of ... based in the company's Chicago office. , UBA Board ... chose to accept this important, strategic position with UBA. ... challenges facing UBA and its Partners as we move ...
Breaking Medicine News(10 mins):Health News:Remove Dark Circles Under Eyes: New Cosmetic Buying Guide Released Online for Men and Women 2Health News:Willem de Liefde, Author and Management Expert, Releases New Guide for Understanding Friends, Family, Co-Workers and Ourselves 2Health News:UNCG School of Nursing Fast-Tracks Medically Trained Veterans 2Health News:Dr. Dental Reveals Exciting New Website 2Health News:Industry Leader Les McPhearson Joins United Benefit Advisors as New Chief Executive Officer 2Health News:Industry Leader Les McPhearson Joins United Benefit Advisors as New Chief Executive Officer 3Health News:Industry Leader Les McPhearson Joins United Benefit Advisors as New Chief Executive Officer 4Health News:Industry Leader Les McPhearson Joins United Benefit Advisors as New Chief Executive Officer 5
... eggs to deteriorate in quality with age, and can that ... egg -- out of a stash of roughly one million ... be influenced to pick a "good" quality egg rather than ... much on the mind of fertility researcher Teresa Woodruff. Woodruff, ...
... a key protein might reap rewards for people ... (HealthDay News) -- Researchers have uncovered cellular proteins that ... according to a new study. , The findings, ... new treatments for a range of human diseases that ...
... WASHINGTON, June 19 Most seniors -,regardless ... Medicare or Medicare,Advantage - oppose cutting the ... payment fix and believe cuts to Medicare ... a new survey finds., Power Point ...
... Protections for Poor Beneficiaries, SAN FRANCISCO, June ... federal court today in the Medicare Part D ... has agreed to make,significant changes to its administration ... approved by the judge, the agreement will,make it ...
... DALLAS, June 19 Federal Reserve chairman Ben Bernanke,s,comments ... health care,system is one of the biggest challenges facing ... care costs will rise nearly 10 percent this,year, lend ... emphasis on,prevention and wellness, according to U.S. Preventive Medicine, ...
... Better Health offers members access to 75 generic drugs at no cost ... ... Independence Blue Cross (IBC),will waive copays and coinsurance on 75 generic drugs ... a member incentive,program designed to help our members become more actively involved ...
Cached Medicine News:Health News:New photo 'op' for ovaries may solve some mysteries of infertility 2Health News:Autoimmune Disease Treatment May Not Dampen Immune System 2Health News:Autoimmune Disease Treatment May Not Dampen Immune System 3Health News:Autoimmune Disease Treatment May Not Dampen Immune System 4Health News:Seniors Oppose Cutting Medicare Advantage to Fund Physician Payment Fix 2Health News:Bush Administration Settles Nationwide Class Action in Medicare Prescription Drug Case 2Health News:Bush Administration Settles Nationwide Class Action in Medicare Prescription Drug Case 3Health News:U.S. Preventive Medicine Views Bernanke's Comments as Strong Support for Prevention and Wellness Programs 2Health News:Independence Blue Cross Waives Copays for Generics Used to Treat Certain Chronic Conditions 2Health News:Independence Blue Cross Waives Copays for Generics Used to Treat Certain Chronic Conditions 3Health News:Independence Blue Cross Waives Copays for Generics Used to Treat Certain Chronic Conditions 4
... Rail clamp with self-adjusting adaptability to ... permits complete versatility of angling at the ... The 3/D Swinger permits it to be ... With the Iron Intern®, a simple adjustment ...
Stainless steel construction to withstand sterilization modalities (EtO) Wide angle of view...
Inquire...
Inquire...
Medicine Products: