Navigation Links
Sangamo BioSciences Presents Clinical Data From Key SB-728-T HIV Studies: Proof Of Concept For Ongoing Sustained Functional Control Of HIV Viral Load; Cytoxan Preconditioning Successfully Enhances Engraftment
Date:12/6/2013

ol of HIV infection may be possible. New data from  the SB-728-1101 study demonstrating a clear relationship between increasing the dose of Cytoxan and increased levels of both engrafted SB-728-T and total CD4 T-cell counts further support this hypothesis and suggest that with these, or higher doses, levels of SB-728-T that will enable functional control of the virus may be reliably attained.

Each of the two trials addressed a different approach to maximizing engraftment of infused SB-728-T that had undergone biallelic modification of the CCR5 gene. Inclusion of newly eligible subjects in the analysis strengthened previous data demonstrating a statistically significant correlation (p=0.008) between estimated number of engrafted biallelically modified cells and the reduction in viral load (VL) during a treatment interruption (TI) from antiretroviral therapy (ART). 

"The decreases observed in viral load in several subjects on both of these trials have been very impressive and are not something that one would expect to happen by chance," stated Gary Blick, M.D., AAHIVS, Medical & Research Director, CIRCLE CARE Center and an investigator on both studies. "Furthermore, the data that have been generated in the course of the clinical investigation of this novel therapy on reductions in viral load and the levels of viral reservoir, as well as the increases in total CD4 cells, demonstrate that a single SB-728-T treatment has the unique ability to enable sustained immunological functional control of HIV in the absence of ART."

In the SB-728-902 Cohort 5 study, bialleic modification of the infused CD4 cells could be approximately doubled by treating subjects heterozygous for the naturally occurring CCR5 delta-32 mutation. Three of eight evaluable CCR5 delta-32 heterozygous subjects with high levels of engraftment achieved a VL at or below the limit of quantification during a TI. This includes two of seven subjec
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Sangamo BioSciences Reports Second Quarter 2012 Financial Results
2. Sangamo BioSciences to Webcast Analyst Briefing on Thursday, December 6, 2012
3. Sangamo BioSciences Reports Fourth Quarter And Full Year 2012 Financial Results
4. Sangamo BioSciences Announces Presentation At 33rd Annual Cowen And Company Health Care Conference
5. Sangamo BioSciences Announces Presentation At The Barclays Global Healthcare Conference
6. Sangamo BioSciences Announces First Quarter 2013 Conference Call and Webcast
7. Sangamo BioSciences Reports First Quarter 2013 Financial Results
8. Sangamo BioSciences Announces Second Quarter 2013 Conference Call And Webcast
9. Sangamo BioSciences Announces Publication of First Demonstration of Inactivation of Extra Chromosome Responsible for Down Syndrome
10. Sangamo BioSciences Reports Second Quarter 2013 Financial Results
11. Sangamo BioSciences Announces Notice Of Allowance For New Patent Application Covering Genome Modification Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... Integrated Silicon Solution, Inc. (Nasdaq: ... IC solutions, today announced that it will host its ... 7:00 a.m. Pacific Time (10:00 a.m. Eastern Time) to ... third quarter ended June 30, 2014. To ... 6:50 a.m. Pacific time on July 24, 2014.  The ...
(Date:7/10/2014)... Ariz. , July 10, 2014   Ventana ...  Group, today announced it has entered into an agreement ... which operates as EMD Serono in the ... , to collaborate with Merck KGaA,s biopharmaceutical division on ... for an undisclosed target using Ventana,s proprietary diagnostic assays. ...
(Date:1/15/2014)... MILTON, N.Y. , Jan. 15, 2014 Sono-Tek Corporation ... three months ended November 30, 2013, compared to sales of ... or 20%. Once again, this quarter has also shown growth ... in the first quarter of this fiscal year. Markets that ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4
(Date:7/10/2014)... News) -- Nature, not nurture, may play the bigger ... new study finds. "As is the case in ... abilities in chimpanzees," William Hopkins of the Yerkes National ... release from the journal Current Biology . ... of intelligence in humans, Hopkins, team said. According ...
(Date:7/10/2014)... THURSDAY, July 10, 2014 (HealthDay News) -- Adults with ... physically abused as children or teenagers than people who ... study. Dyslexia, which affects up to 10 ... Researchers found that 35 percent of adults with this ... compared to 7 percent of those without dyslexia. ...
(Date:7/10/2014)... Kristen Fischer HealthDay Reporter ... help ease the hot flashes that often accompany menopause, new ... than 50 percent of menopausal women, said Dr. Taraneh Shirazian, ... at the Icahn School of Medicine at Mount Sinai Hospital ... more than 10 hot flashes a day, and she added ...
(Date:7/10/2014)... Dennis Thompson HealthDay Reporter ... the Twitter wars that break out regularly between outspoken celebrities ... for your own relationship, a new study suggests. High ... couple, even if the couple is in a long-term relationship, ... users. In turn, that friction can lead to cheating ...
(Date:7/10/2014)... response to today,s announcement that the "Mississippi Baby," believed ... been found to have detectable levels of the virus, ... in this setback but remains hopeful that the scientific ... undetectable for more than two years will continue to ... develop a cure. , "Although we had high ...
Breaking Medicine News(10 mins):Health News:Like Humans, Chimps' Smarts May Rely on Genes 2Health News:Researchers See Link Between Dyslexia, Abuse 2Health News:Losing Weight May Ease Hot Flashes, Study Finds 2Health News:Losing Weight May Ease Hot Flashes, Study Finds 3Health News:Are You Tweeting Your Marriage Away? 2Health News:Are You Tweeting Your Marriage Away? 3Health News:Despite setback, 'Mississippi Baby' represents significant breakthrough in effort to end AIDS 2
... August 2-3, CHICAGO, June 30 From ... nurses and related professionals play a critical,role in ... The Dermatology Nurses, Association (DNA) will offer dermatology,professionals ... formats and,the profession,s best networking opportunities during the ...
... Heart,Association has set August for the premier of Circulation: ... titles to be published,under the banner of Circulation: Journal ... by Lippincott Williams & Wilkins, a part of,Wolters Kluwer ... editor of the new journal. Faxon,is director of strategic ...
... included as part of company,s, comprehensive Pressure Ulcer Prevention Program ... ... MUNDELEIN, Ill., June 30 Medline Industries, Inc.,announced today ... pads and stretcher pads aimed at helping,hospitals and long-term care ...
... the development, marketing and sale of proprietary, patent-pending nutraceutical products, including ... is launching a new pet health care division. , ... ... -- The pet health care division is designed to expand ...
... Results of 2008 World Safety Declaration Survey, ... across organizations, extending it beyond the workplace and ... collaboration and sharing are critical,for keeping employees safe, ... World Safety Declaration (WSD)., The survey results ...
... Robbins & Myers, Inc.,(NYSE: RBN ) today reported ... fiscal third quarter ended May 31, 2008, including $0.14 ... the sale of two product lines in March 2006. ... year period to $0.62,primarily due to higher sales, operating ...
Cached Medicine News:Health News:4th Annual Dermatology Nurses' Association Summer Meeting to Arrive in Windy City 2Health News:American Heart Association Announces Fourth New Journal - Circulation: Cardiovascular Interventions to Debut in August 2Health News:American Heart Association Announces Fourth New Journal - Circulation: Cardiovascular Interventions to Debut in August 3Health News:American Heart Association Announces Fourth New Journal - Circulation: Cardiovascular Interventions to Debut in August 4Health News:Medline Announces Advanced Line of Therapeutic Mattresses, Operating Room Table Pads and Stretcher Pads 2Health News:Medline Announces Advanced Line of Therapeutic Mattresses, Operating Room Table Pads and Stretcher Pads 3Health News: University Health Industries Launches Natural Pet Health Care Division 2Health News:Companies Report Success in Driving Safety Culture at Workplaces 2Health News:Companies Report Success in Driving Safety Culture at Workplaces 3Health News:Companies Report Success in Driving Safety Culture at Workplaces 4Health News:Robbins & Myers Reports Record Third Quarter Results 2Health News:Robbins & Myers Reports Record Third Quarter Results 3Health News:Robbins & Myers Reports Record Third Quarter Results 4Health News:Robbins & Myers Reports Record Third Quarter Results 5Health News:Robbins & Myers Reports Record Third Quarter Results 6Health News:Robbins & Myers Reports Record Third Quarter Results 7Health News:Robbins & Myers Reports Record Third Quarter Results 8Health News:Robbins & Myers Reports Record Third Quarter Results 9Health News:Robbins & Myers Reports Record Third Quarter Results 10
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: