Navigation Links
Sangamo BioSciences Initiates Phase 2 Clinical Trial of Treatment for Amyotrophic Lateral Sclerosis (ALS)
Date:9/3/2008

ic," stated Dale Ando, M.D., Sangamo's vice president of therapeutic development and chief medical officer. "The drug is designed to activate the expression of the subject's own VEGF-A gene. There is mounting pre-clinical and clinical evidence to support a correlation between reduced VEGF-A levels and progression of this life-threatening disease. Our Phase 1 clinical studies of SB-509 in diabetic neuropathy have shown that the drug is well tolerated. Data from this clinical study and pre-clinical studies in animal models of nerve damage reveal positive effects of SB-509 on motor nerve function and muscle composition. Similar effects on motor nerves and muscles in these patients may slow the progression of ALS by preserving nerve function and improving muscle fiber composition and strength."

The Phase 2 trial (SB-509-801) is a randomized repeat-dosing, open-label, multi-center study designed to evaluate the effect of intramuscular administration of SB-509 on the progression of the disease in subjects with ALS, as measured by the ALS Functional Rating Scale-Revised (ALSFRS-R) a validated rating instrument for monitoring the progression of disability in patients with ALS. Efficacy of SB-509 will be evaluated by comparing the rate of ALS disease progression in subjects treated with SB-509 in this study to historical placebo controls. In addition to gathering data on safety and tolerability of SB-509 in subjects with ALS, data will be collected to evaluate the effect of SB-509 on additional clinical measures. These measures include Forced Vital Capacity (FVC), a test of lung function; Neurophysiologic Index (NI), a measure of neurologic impairment; Manual Muscle Test (MMT), a test of muscle strength; and survival. Finally, the study will also evaluate stem cell mobilization in subjects with ALS receiving SB-509.

"We are pleased to meet our goal of beginning a Phase 2 clinical trial in ALS this year and are very excited to begin these proof of principle stud
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
2. Sangamo BioSciences Announces Completion of Enrollment of Phase 2 Clinical Trial of ZFP Therapeutic for Diabetic Neuropathy
3. Sangamo BioSciences Reports 2007 Fourth Quarter and Year-End Financial Results
4. Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of Knock-Out Cell Lines
5. Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting
6. Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs
7. Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting
8. Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant T Cells
9. ImmuneRegen BioSciences Reports Material Transfer Agreement with VaxGen, Inc.
10. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
11. Upstream Biosciences Acquires Innovative Platform Technology and Drug Candidates for Tropical Parasitic Diseases

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2009)...KE CITY, Nov. 27 Booth -...(NYSE: VAR ), a premier supplier of X-ray tubes ...it its full range of detectors at the RSNA Annual ...er 3, 2009. Varian will also be exhibiting X-ray ... specialized cancer treatment technologies. ,,...
(Date:11/26/2009)...ESBURG, South Africa, Nov. 26 The ...the Year Award in the Generic Pharmaceutical Marke...d. ,, (Logo: http://www.newscom.com/cgi-bin/pr...Year Award, the following criteria were used to be...petitors: growth strategy and implementation, degr...
(Date:11/25/2009)...D, Colo., Nov. 25 Heska ... of advanced diagnostic and specialty products t...nts with Roche Diagnostics Corporation for the sup...es for the veterinary market. ,, (Logo: ht...GO ) ,, "Heska and Roche share the same passion...
Breaking Medicine Technology:Varian Medical Systems to Highlight the Latest Digital Detectors, X-ray Tubes and Cancer Treatment Technology at the Radiological Society of North America (RSNA) Annual Meeting in Chicago 2Frost & Sullivan Award Underlines Cipla Medpro's Status as Company of the Year in the South African Generic Pharmaceutical Market 2Frost & Sullivan Award Underlines Cipla Medpro's Status as Company of the Year in the South African Generic Pharmaceutical Market 3Frost & Sullivan Award Underlines Cipla Medpro's Status as Company of the Year in the South African Generic Pharmaceutical Market 4Heska Announces Supply Agreement With Roche Diagnostics 2Heska Announces Supply Agreement With Roche Diagnostics 3Sensor biochips could aid in cancer diagnosis and treatment 10469 1Sensor biochips could aid in cancer diagnosis and treatment 10469 2Sensor biochips could aid in cancer diagnosis and treatment 10469 3Harvard scientists bend nanowires into 2 D and 3 D structures 14571 1Harvard scientists bend nanowires into 2 D and 3 D structures 14571 2Widely used virus assay shown unreliable when compared to other methods 10467 1Widely used virus assay shown unreliable when compared to other methods 10467 2
...c , , ROCHESTER, Minn., March 23 Here are highli...yo Clinic,s research magazine. You may cite and li...nting is allowed with proper attribution. Please i...our editorial policies permit: Visit http://disco..., , Parkinsonism: A Microtubule Railroad System D...
...the Tide on Antibiotic-Resistant Infections , , P...Foundation (RWJF) and the Plexus Institute (Plexus...tifaceted methicillin-resistant Staphylococcus au...tive deviance (PD), a novel approach to social and...ons in MRSA incidence ranging from 26 to 62 percen...
Other Medicine Technology:Discovery's Edge Spring Issue - http://discoverysedge.mayo.edu 2CDC Analysis Finds Unique Social and Behavior Intervention Helps Reduce MRSA Rates Up to 62% in Study Hospitals 2CDC Analysis Finds Unique Social and Behavior Intervention Helps Reduce MRSA Rates Up to 62% in Study Hospitals 3CDC Analysis Finds Unique Social and Behavior Intervention Helps Reduce MRSA Rates Up to 62% in Study Hospitals 4
(Date:11/29/2009)...tional healthcare,s uncertain future and rising co...e care. Affordable Acupuncture Scottsdale answers ...ber 29, 2009 -- Affordable Acupuncture, LLC opened... been met with enthusiasm and gratitude. Its incre...ed to two things, need and cost. "As far as ...
(Date:11/28/2009)...eved to affect circadian rhythm, , ,... suggests that an internal body clock that goes on... bipolar disorder in children. , The finding r...of 152 children with bipolar disorder, which can m...40 children without the disorder. They linked vari...
(Date:11/27/2009)...ch firm Replikins Ltd. today issued its latest bio... It shows that the lethality of the virus has drop...us,s current outbreak in the spring of 2009 to res...1). The H1N1 infectivity count, however, remains i...) November 27, 2009 -- Biotech firm Replikins Ltd....
(Date:11/27/2009)..., France, Nov. 27 Team Garmin-Slip...am dedicated to ethical sporting and developing th...today that it will become Team Garmin-Transitions ...sponsor of the team. Transitions Optical is the wo...fering the most advanced photochromic technology i...
(Date:11/27/2009)...ented medical, economic burdens, study predicts ,...e number of people with diabetes in the United Sta...a new study predicts. , That would bring the to...disease, up from 23.7 million today. , , At the ...es will triple, the study also warns, rising from ...
Breaking Medicine News(10 mins):Health News:Affordable Acupuncture Greeted with Open Arms by Scottsdale and Phoenix Communities 2Health News:Bipolar Disorder May Be Tied to Body Clock 2Health News:Lethality of H1N1 Virus Drops to "Non-Epidemic Resting Levels" in Current Cycle; Virus' Infectivity Remains Increased 2Health News:Lethality of H1N1 Virus Drops to "Non-Epidemic Resting Levels" in Current Cycle; Virus' Infectivity Remains Increased 3Health News:Lethality of H1N1 Virus Drops to "Non-Epidemic Resting Levels" in Current Cycle; Virus' Infectivity Remains Increased 4Health News:Lethality of H1N1 Virus Drops to "Non-Epidemic Resting Levels" in Current Cycle; Virus' Infectivity Remains Increased 5Health News:Team Garmin-Slipstream Officially Re-named Team Garmin-Transitions With Addition of Transitions Optical as New Sponsor 2Health News:Team Garmin-Slipstream Officially Re-named Team Garmin-Transitions With Addition of Transitions Optical as New Sponsor 3Health News:Diabetes Cases Expected to Double in 25 Years 2Health News:Diabetes Cases Expected to Double in 25 Years 3
... The number of adults suffering severe heart probl...985 to 2000 a study showed, //indicating the benef...at has assisted in better diagnosis and treatment,...srupting the supply of oxygen to the body. Marelli...
... Scientists have developed a scan that could spot ...iver-related illness.// The new machine, whic...s the degree of liver damage drinkers may be doing...er through the stomach wall. However, this could d...
... “Consuming fatty dairy products may actually help...t health specialists have cautioned people to be w...omen were involved in this study. At the end of th...roducts like cheese and butter. According to t...
... There are many agencies which are involved in dif...of such research findings. Each agency may come ou...ased on the funding agency. In this connection...ustry funds a study it is the normal trend of the ...
... Pre-eclampsia, an extremely undesirable condition... mother and child. The condition is said to claim ...n. Now, scientists have devised a new diagnostic e...hat the presence of a particular protein in the ur...
... The primary problem of burn victims is infection....said to combat infections in human body.// This is...t against diseases. Now researchers have found tha...nd healing specialist with Cincinnati Shriners Hos...
Other Medicine News:
...choices for finishing. The first choice was to pro...eant longer delay to deliver the order. The altern...eant a substantial investment when additional offi...pace and employee training. TOPscan Remote Tracing...
...rate, and reliable tests of a wide variety of visu...ditions for viewing far point test charts at 5 met...est charts at 30cm (12"). The SS-3, which is very ...an be interchanged as required. The tests show, fo...
Topcon OM-B1 Opthalmometer
... standard in powerful imaging software, and a Comp...ble an easy to use color fundus screening package....gital imaging software with Topcons Non-Mydriatic ...ghly accurate color-digital retinopathy screenings...
Medicine Products: