Navigation Links
Sangamo BioSciences Announces Presentation of Positive Clinical Data From Novel ZFN Therapeutic Approach for the Treatment of HIV/AIDs at Conference for Retroviral and Opportunistic Infections
Date:2/28/2011

d in a durable improvement in total CD4+ T-cell counts in five of six of the subjects analyzed.  In addition, five of the six subjects also exhibited sustained improvements in their CD4:CD8 T-cell ratio, which is an indicator of immunologic health. The ZFN-CCR5-modified cells also exhibited normal T-cell growth kinetics and trafficking and were observed to undergo selective expansion in the gut mucosa, a major reservoir of virus in the body, suggesting, as predicted, that the cells were resistant to HIV infection. These data represent the necessary first steps in the development of a "functional cure" for HIV/AIDS by providing a protected CD4+ T-cell population in these subjects that is resistant to HIV infection.

The presentation will be made at the 18th Conference on Retroviruses and Opportunistic Infections (CROI) which is being held in Boston from February 27 to March 2, 2011.  In a late-afternoon session on Wednesday, March 2, 2011, Dr. June will present further data from Sangamo's Phase 1 trials of SB-728-T and Paula Cannon, Ph.D., Associate Professor of Molecular Microbiology & Immunology at the Keck School of Medicine of the University of Southern California (USC), will present preclinical data from Sangamo's program of ZFN-modification of the CCR5 receptor in hematopoietic stem cells.  Also at CROI, Sangamo's collaborators at the University of Pennsylvania will describe preclinical data from a program to modify the CXCR4 gene in human CD4+ T-cells. More information about these presentations will be available later in the week.

"These data represent the beginning of a new hope for HIV therapy," said Jacob Lalezari, M.D., the Director of Quest Clinical Research, Assistant Clinical Professor of Medicine at Mount Zion Hospital, UCSF, and one of the principal investigators of the study. "This approach aims to provide a protected reservoir of HIV-resistant T-cells that are available to fight infections including the virus.  I
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
2. Sangamo BioSciences Announces Completion of Enrollment of Phase 2 Clinical Trial of ZFP Therapeutic for Diabetic Neuropathy
3. Sangamo BioSciences Reports 2007 Fourth Quarter and Year-End Financial Results
4. Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of Knock-Out Cell Lines
5. Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting
6. Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs
7. Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting
8. Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant T Cells
9. Sangamo BioSciences Initiates Phase 2 Clinical Trial of Treatment for Amyotrophic Lateral Sclerosis (ALS)
10. Sangamo BioSciences Provides Update on Companys 2008 Progress and 2009 Objectives
11. Sangamo BioSciences Announces Presentations at Two Upcoming Investor Conferences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... 3, 2015 With a population of more ... and therefore also its single largest potential market for ... has led all major world economies in the average ... and government health expenditures. As an in vitro diagnostics ... of the United States, western European countries, and Japan. ...
(Date:9/3/2015)... About cardiovascular implants ... or blockage of blood vessels. Cardiac disease is ... cholesterol, and high blood pressure. Coronary artery disease, ... failure are some of the major cardiac diseases. ... coronary arteries, is one of the most common ...
(Date:9/3/2015)... Sept. 3, 2015  WellCare Health Plans, Inc. (NYSE: ... , senior vice president and chief financial officer, is ... Healthcare Conference on Wednesday, September 9, 2015, at 9:25 ... webcast live. In addition, a replay of the webcast ... broadcast. Both the live broadcast and the replay will ...
Breaking Medicine Technology:IVD in China 2IVD in China 3IVD in China 4IVD in China 5IVD in China 6IVD in China 7IVD in China 8IVD in China 9IVD in China 10IVD in China 11IVD in China 12IVD in China 13Global Cardiovascular Implants Market 2015-2019 2
... BETHESDA, Md., July 05, 2007 /PRNewswire-FirstCall/ -- Micromet,Inc. ... of,novel, proprietary antibody-based products for cancer, inflammatory,and autoimmune ... Chief Executive Officer of Micromet, Inc., will,present at ... in New York on Thursday, July 12, 2007 ...
... WIRE)--Jul 2, 2007 - Tercica, Inc.,(NASDAQ:TRCA) today announced ... at the C.E. Unterberg, Towbin,Emerging Growth Opportunities Conference ... Wednesday, July 11, 2007 at 4:00 p.m. Eastern,time ... and slide presentation will be available,via the Internet ...
Cached Medicine Technology:Micromet, Inc. to Present at the 3rd Annual C.E. Unterberg, Towbin,Emerging Growth Conference 2
(Date:9/4/2015)... ... September 04, 2015 , ... Keeping mold top of ... the home is quite common. Mold can grow anywhere - on carpet, clothing, food, ... Checking for excessive moisture and water in the home is key to preventing mold ...
(Date:9/4/2015)... ... September 04, 2015 , ... Many consumers are looking for a quick and convenient ... solution. , The patent-pending K Med Cups provide a quick and simple way to brew ... a cold, flu or cough. As a result, they enhance comfort and health. The invention ...
(Date:9/4/2015)... (PRWEB) , ... September 04, 2015 , ... Having access ... This has led to an increasing amount of unnecessary emergency room visits which affects ... and taxes the country’s health bill. Fortunately, a solution to alleviate this problem has ...
(Date:9/4/2015)... ... September 04, 2015 , ... Compliance officers ... settlements under the Stark physician self-referral law. “Stark Law DOs and DON’Ts: ... Atlantic Information Services, Inc. (AIS), will detail which deals are attracting the most ...
(Date:9/4/2015)... GENEVA, IL (PRWEB) , ... September 04, 2015 , ... ... in Geneva, IL hosting Generation Rescue’s A Night of Hope event supporting families affected ... Ed French and Rowena and Joe Salas, joined together at the Oscar Swan Inn ...
Breaking Medicine News(10 mins):Health News:September is Mold Awareness Month 2Health News:September is Mold Awareness Month 3Health News:September is Mold Awareness Month 4Health News:Redesigned Packaging for Powdered Medicinal Mix Invented by InventHelp® Client (CBA-2637) 2Health News:Telemedicine Platform DocChat Announces Launch Offering a Way for Patients to Consult Doctors and Receive Prescriptions 24/7 2Health News:Telemedicine Platform DocChat Announces Launch Offering a Way for Patients to Consult Doctors and Receive Prescriptions 24/7 3Health News:Sept. 17 Webinar to Offer Best Practices for Physician Contracts 2Health News:Jenny McCarthy & Donnie Wahlberg Help Raise Over $200,000 For Generation Rescue’s ‘Night Of Hope’ Chicago Charity Event 2
... Dotinga HealthDay Reporter , WEDNESDAY, April 4 (HealthDay ... HIV vaccine failed to protect most people who received it, ... vaccine efforts. Scientists believe an HIV vaccine, designed to ... several years away. Tests of experimental vaccines have largely been ...
... criticized as having misogynistic messages and images. While more ... "brands" in recent years, critics argue that many of ... with regard to race, gender and sexuality in popular ... in the University of Missouri School of Journalism, and ...
... MA (April 4, 2012)-- IntegraGen, Inc., a biotechnology company ... of the ARISk Risk Assessment Test, a gender specific, ... associated with Autism Spectrum Disorder (ASD). The test is ... from multiplex familiessiblings of children with ASD who are ...
... By Steven Reinberg HealthDay Reporter , WEDNESDAY, ... appears to lengthen the lives of patients with a ... a small phase 2 trial. The drug, belagenpumatucel-L ... cell lung cancer and increased the five-year survival rate ...
... cancer (IBC) is a very aggressive, often misunderstood type of ... with other types of breast cancer. The five-year survival rate ... rate for other types of breast cancer. The reason for ... often spreads quickly to other parts of the body, including ...
... (HealthDay News) -- ,People with metal-on-metal hip replacements do not ... years after they receive the device, according to a new ... researchers at the Universities of Bristol and Exeter in the ... Registry of England and Wales, which contains records on more ...
Cached Medicine News:Health News:From a Failed Vaccine, New Insights Into Fighting HIV 2Health News:Sexual objectification of female artists in music videos exists regardless of race, MU study finds 2Health News:IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children 2Health News:IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children 3Health News:Early Study Finds Some Promise for Lung Cancer Vaccine 2Health News:Researchers develop a new cell and animal model of inflammatory breast cancer 2Health News:Researchers develop a new cell and animal model of inflammatory breast cancer 3Health News:No Added Cancer Risk From Hip Replacement Materials: Study 2
... Reviews enable all those involved with healthcare ... the very latest evidence in their field ... harder each year as the volume of ... by delivering the best single source available ...
Treatment Strategies in Cardiovascular Medicine...
Pocket Medicine's Cardiology Bundle includes the following 4 applications: Treatment Strategies in Cardiovascular Medicine, Treatment Strategies in Interventional Cardiology, Treatment Strategies in ...
The first book to translate key medical data into clear guidelines capturing the highest treatment standards for heart disease....
Medicine Products: