Navigation Links
Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting
Date:6/8/2008

tion of SB-509 in diabetics with moderate to severe diabetic peripheral sensory motor neuropathy in the legs. The trial is being conducted at multiple sites, accrual has been completed and plans recently announced to expand the study and enroll additional subjects.

In the initial trial, 45 subjects have completed enrollment. Subjects were randomized to one of two groups in a 2:1 ratio. The larger group (approximately 30 subjects) was treated by intramuscular injection of 60 mg of SB-509 (30 mg of SB-509 per leg) into the lower limb and will be treated every 3 months. The remaining group (approximately 15 subjects) received an equal volume of placebo on the same schedule. Each subject will receive a total of two treatments (Day 0 and 90). Subjects receive injections in a distribution pattern that targets the major peripheral nerves in the legs and feet.

As announced on June 6, 2008, Sangamo will expand the Phase 2 study by enrolling approximately 45 additional subjects in the trial. Subjects will again be randomized to one of two groups in a 2:1 ratio. The larger group (approximately 30 subjects) will be treated by intramuscular injection of 60 mg of SB-509 (30 mg of SB-509 per leg) into the lower limb every 2 months. The remaining group (approximately 15 subjects) will receive an equal volume of placebo on the same schedule. Each subject will receive a total of three treatments (Day 0, 60 and 120). Subjects will receive injections in the same pattern used in the initial part of the trial.

The symptoms of diabetic peripheral neuropathy and any changes that occur during the trial will be evaluated based on neurological examination data, electrophysiological testing data, subject neurological questionnaire, and subject pain assessment. Specifically, investigators will assess pain using VASPI, and use scoring systems such as a modified NIS-LL and TNS to quantify neurologic exam and assess signs and symptoms of the condition.

For each subject
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs
2. Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting
3. Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of Knock-Out Cell Lines
4. Sangamo BioSciences Reports 2007 Fourth Quarter and Year-End Financial Results
5. Sangamo BioSciences Announces Completion of Enrollment of Phase 2 Clinical Trial of ZFP Therapeutic for Diabetic Neuropathy
6. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
7. Regado Biosciences Announces Publication in Circulation of Clinical Trial Results of REG1 Anticoagulation System
8. Magellan Biosciences Companies to Feature Automated Products and New Tests for MRSA at the American Society for Microbiology Meeting, Booth 743
9. Ardea Biosciences Presents Preclinical Data on RDEA119 Demonstrating Favorable Anti-Inflammatory Profile for Potential Use in Ulcerative Colitis
10. Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594
11. Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... , May 23, 2013  The need to ... treatment continuum was highlighted prominently at the 108 ... Association (AUA), in San Diego.  According to SonaCare ... focused ultrasound (HIFU) technology, the need for image-guided ... for urologists to consider minimally invasive ablative treatments, ...
(Date:5/23/2013)... , May 23, 2013  Texas, premier physician associations ... doctors the survival tools they need to provide demonstrably ... today,s health care marketplace. "I am confident ... local practices," said Stephen L. Brotherton ... " Texas doctors are determined to ...
(Date:5/23/2013)... TARRYTOWN, N.Y. , May 23, 2013 /PRNewswire/ ... reconstruction following mastectomy is an appropriate option ... mutations seeking to surgically reduce their breast cancer ... involves a gradual expansion process and a second ... of implants in the same surgery as mastectomy ...
Breaking Medicine Technology:Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 2Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 3Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 4Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 5Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 6TMA Launches Physician Services Organization for Patient Care 2TMA Launches Physician Services Organization for Patient Care 3TMA Launches Physician Services Organization for Patient Care 4Direct to Implant ("One Step") Mastectomy Breast Reconstruction Reduces Number of Surgeries and Time to Final Cosmetic Results 2Direct to Implant ("One Step") Mastectomy Breast Reconstruction Reduces Number of Surgeries and Time to Final Cosmetic Results 3
... WASHINGTON, June 20, 2011 The Consumer Healthcare ... response to Texas Governor Rick Perry signing into ... allowing law-abiding citizens to access common cold and ... that exceed the legal limit: "We ...
... a pilot for as long as he can remember.  His passion ... play with toy planes instead of cars, and grew when he ... to Disney World.  At 8-years old Baniecki scribbled down on a ... placed it into a time capsule.  Ten years later, Baniecki pulled ...
Cached Medicine Technology:Pilot's Dream Comes True Thanks to New Robotic Surgery 2Pilot's Dream Comes True Thanks to New Robotic Surgery 3Pilot's Dream Comes True Thanks to New Robotic Surgery 4
(Date:5/25/2013)... great companions for senior citizens, but elderly people who always ... likely to crash than those who never drive with a ... licensed drivers aged 70 and older. The nearly 700 participants ... their pet in the car. Among those who always ... high as among those who never drove with their pet. ...
(Date:5/25/2013)... (PRWEB) May 25, 2013 Providing patients with ... Diet Doc team of weight management professionals. But, aside from ... and effectively, Diet Doc’s hCG diets also provide ... abuse during childhood like bullying, more control over their lives ... of dealing with the underlying factors of weight gain derived ...
(Date:5/25/2013)... NY (PRWEB) May 25, 2013 ... problems, ranging from irritable bowel syndrome (IBS) to ... are among the most long-lasting, embarrassing, frustrating and ... natural foods for digestive health have provided ... there are many factors contributing to digestive health ...
(Date:5/25/2013)... 2013 Many orthodontists have thought about ... exactly that cloud is. Most people would naturally ... to provide their cloud service and support would own ... service they're selling, they'd be wrong. Cloud providers ... secure, redundant facility that houses servers and related equipment ...
(Date:5/25/2013)... 25, 2013 The Slim Weight Patch has ... results. This is due to the highly sought after ingredients ... weight patch offers an extra 2 months supply & premium ... and get the body you desire faster than ever. , ... , With Slim weight patch consumers can observe instant ...
Breaking Medicine News(10 mins):Health News:Seniors More Likely to Crash When Driving With Pet: Study 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces hCG Diet Plans for Those Suffering from Abuse-Related Weight Gain 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces hCG Diet Plans for Those Suffering from Abuse-Related Weight Gain 3Health News:Natural Foods For Digestive Health Report and Video Published by BetterDigestion.org 2Health News:Cirrus Ortho Launches Cloud Computing for Orthodontic Industry That is Unlike Any Other 2Health News:Slim Weight Patch Advanced Weight Loss System Offers Extra Two Month Supply and Membership for Maximum Weight Loss 2
... weight training has grown over the past decade. A ... and Policy of The Research Institute at Nationwide Children,s ... weight training has increased as well. The study found ... in U.S. hospital emergency departments between 1990 and 2007, ...
... Parents usually call the shots; doctors unclear in their explanations, ... children with cancer who are enrolled in clinical research trials, ... in research from their parents and doctors, a new report ... cancer patients, ages 7 to 18, and found that ...
... ... girls’ health and education. IDOL GIVES BACK to benefit the UN Foundation Wednesday, April 21, ... Washington, DC ... in Ethiopia as a guest of the United Nations Foundation to learn about ...
... , ... Jackson, MI, based manufacturing and design firm, has brought over 35 years of experience ... and antimicrobial copper carts, storage cabinets, workstations, and tables, as well as cleaning and ... ...
... Don Chapin, one ... AARP article entitled "Love is (Not) All You Need." In the AARP article, the ... to protect their remaining savings to be Medicaid compliant. According to Chapin, the advice ... ...
... from Boston University School of Medicine found that women with ... lower risk of developing gout than men. This study, ... and gout risk in women, also evaluated purported risk factors ... use, and diuretic use to be among leading contributors for ...
Cached Medicine News:Health News:New national study examines weight training-related injuries 2Health News:New national study examines weight training-related injuries 3Health News:Many Kids Not Fully Informed of Their Role in Cancer Studies 2Health News:AMERICAN IDOL's David Cook Travels to Ethiopia with the UN Foundation 2Health News:AMERICAN IDOL's David Cook Travels to Ethiopia with the UN Foundation 3Health News:Midbrook Medical Brings Industrial Experience to Medical Fabrication 2Health News:Midbrook Medical Brings Industrial Experience to Medical Fabrication 3Health News:Prominent National Elder Law Attorney Disputes AARP Article Recommending Divorce to Afford Health Care 2Health News:Prominent National Elder Law Attorney Disputes AARP Article Recommending Divorce to Afford Health Care 3Health News:Obesity, hypertension, alcohol and diuretic use -- gout risk factors for women 2
... Total PSA method for Dimension integrated ... is an in vitro diagnostic test ... specific antigen (TPSA) in human serum ... an aid in the detection of ...
... offers a comprehensive line of pregnancy tests ... urine in convenient one-step stick and cassette ... options. Clearview Easy HCG is a 25 ... format. Clearview HCG II provides 25mIU ...
The BioCheck hCG ELISA is intended for the quantitative determination of human chorionic gonadotropin (hCG) concentration in human serum. The assay is for use in the early diagnosis of pregnancy in a...
The BioCheck Ferritin ELISA is intended for the quantitative determination of ferritin in human serum. This assay is to be used in the diagnosis of diseases affecting iron metabolism....
Medicine Products: