Navigation Links
Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting
Date:6/8/2008

tion of SB-509 in diabetics with moderate to severe diabetic peripheral sensory motor neuropathy in the legs. The trial is being conducted at multiple sites, accrual has been completed and plans recently announced to expand the study and enroll additional subjects.

In the initial trial, 45 subjects have completed enrollment. Subjects were randomized to one of two groups in a 2:1 ratio. The larger group (approximately 30 subjects) was treated by intramuscular injection of 60 mg of SB-509 (30 mg of SB-509 per leg) into the lower limb and will be treated every 3 months. The remaining group (approximately 15 subjects) received an equal volume of placebo on the same schedule. Each subject will receive a total of two treatments (Day 0 and 90). Subjects receive injections in a distribution pattern that targets the major peripheral nerves in the legs and feet.

As announced on June 6, 2008, Sangamo will expand the Phase 2 study by enrolling approximately 45 additional subjects in the trial. Subjects will again be randomized to one of two groups in a 2:1 ratio. The larger group (approximately 30 subjects) will be treated by intramuscular injection of 60 mg of SB-509 (30 mg of SB-509 per leg) into the lower limb every 2 months. The remaining group (approximately 15 subjects) will receive an equal volume of placebo on the same schedule. Each subject will receive a total of three treatments (Day 0, 60 and 120). Subjects will receive injections in the same pattern used in the initial part of the trial.

The symptoms of diabetic peripheral neuropathy and any changes that occur during the trial will be evaluated based on neurological examination data, electrophysiological testing data, subject neurological questionnaire, and subject pain assessment. Specifically, investigators will assess pain using VASPI, and use scoring systems such as a modified NIS-LL and TNS to quantify neurologic exam and assess signs and symptoms of the condition.

For each subject
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs
2. Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting
3. Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of Knock-Out Cell Lines
4. Sangamo BioSciences Reports 2007 Fourth Quarter and Year-End Financial Results
5. Sangamo BioSciences Announces Completion of Enrollment of Phase 2 Clinical Trial of ZFP Therapeutic for Diabetic Neuropathy
6. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
7. Regado Biosciences Announces Publication in Circulation of Clinical Trial Results of REG1 Anticoagulation System
8. Magellan Biosciences Companies to Feature Automated Products and New Tests for MRSA at the American Society for Microbiology Meeting, Booth 743
9. Ardea Biosciences Presents Preclinical Data on RDEA119 Demonstrating Favorable Anti-Inflammatory Profile for Potential Use in Ulcerative Colitis
10. Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594
11. Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... , July 11, 2014  Major advances in ... cancer are being highlighted in a three-day Oncology ... from 10-12 July, 2014.  Renowned national and international cancer ... best practices and exchange knowledge on modern technologies ... and efficient. The Summit will ...
(Date:7/10/2014)... , July 10, 2014  Breg, Inc., ... services, has launched the FreeRunner™ knee brace with ... suffer from patella mal-tracking return to active lifestyles. ... than other braces, providing support when patients need ... when they don,t. Patellofemoral issues are ...
(Date:7/10/2014)... AMBLER, Pa. , July 10, 2014 /PRNewswire/ ... visited Moberg Research,s (Moberg) medical device manufacturing facility. ... how Moberg,s advanced neurological monitors facilitate cutting-edge research ... 2011, Rep. Kennedy and mental health advocate, ... non-profit organization dedicated to fostering fundamental changes that ...
Breaking Medicine Technology:Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2
(Date:7/11/2014)... the number of deer in an area can lower ... infections among people, new research indicates. "Our study ... human interactions with deer, infected nymphal ticks and human ... White-tailed deer are the primary host for adult blacklegged ... study included nearly all the permanent residents of a ...
(Date:7/11/2014)... Dennis Thompson HealthDay ... A Mississippi girl born with HIV who was thought to ... with new tests showing detectable levels of the AIDS-causing virus ... The girl, now nearly 4 years old, had remained virus-free ... 18 months old. Doctors had hoped her remission would open ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Microbiology testing ... the in-vitro diagnostics industry, which is expected to pose ... years. The sector owes its growth to the ongoing ... people’s health worldwide and a major factor leading to ... threat of bio-terrorism, and a broader availability of immunosuppressants, ...
(Date:7/11/2014)... July 11, 2014 The report, ... Types, Applications & Geography - 2018,” defines and ... market with an analysis and forecast of the ... synthetic fibers (Para aramids, meta aramids, UHMW Polyethylene, ... including PPS fiber, PBI fiber, PBO fiber, and ...
(Date:7/11/2014)... Datalogic brings a new and innovative scanner ... With their new Gryphon GD4400 and GM4400 ... devastating MRSA, which claimed 5,500 lives, becomes more preventable. ... and the Gryphon GM4400-HC 2D readers can scan nearly ... barcodes off of troublesome LCD monitors, smartphones, and other ...
Breaking Medicine News(10 mins):Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 2Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 3Health News:World Virology and Bacteriology Testing Sector Discussed in Comprehensive VPG Research Report Published at MarketPublishers.com 2Health News:World Virology and Bacteriology Testing Sector Discussed in Comprehensive VPG Research Report Published at MarketPublishers.com 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 2Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 4Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 2Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 3
... myocardial perfusion imaging is common, and in many patients is ... a study in the November 17 issue of JAMA ... is being presented at the American Heart Association,s annual meeting. ... years, but along with the potential benefits has come an ...
... the gradual accumulation in the brain of amyloid-beta peptide which is ... protein known as APP, which is found in three forms. Most ... disease does not distinguish between the different forms of the ... Chemistry , show that amyloid beta peptide is actually created mainly ...
... Reporter , SUNDAY, Nov. 14 (HealthDay News) -- Moderate drinking ... than not drinking at all, according to a trio of ... in Chicago. Not only did male coronary bypass ... was also boosted by a cocktail now and then. ...
... , SUNDAY, Nov. 14 (HealthDay News) -- ... the brain alter how they view themselves and others, ... aptitude for introspection, researchers say. Georgetown University Medical ... of the five scattered brain regions that comprise what,s ...
... of adult smokers dramatically decreased during the past three ... more quitting and fewer picking up the habit, according ... Sessions 2010. The Minnesota Heart Survey, a population-based, serial ... between 3,000 and 6,000 participants in each of its ...
... do not get enough sleep have higher levels of ... researchers have found. Data from a recent study ... the American Heart Association Scientific Sessions in Chicago by ... School of Medicine. The results come from surveying ...
Cached Medicine News:Health News:Common for patients to undergo multiple cardiac imaging tests, with high cumulative radiation dose 2Health News:Common for patients to undergo multiple cardiac imaging tests, with high cumulative radiation dose 3Health News:'Magic number' 695 opens up new areas for Alzheimer's research 2Health News:A Little Alcohol May Help the Heart: Studies 2Health News:A Little Alcohol May Help the Heart: Studies 3Health News:Brain Organizes Itself for Introspection as Children Age: Study 2Health News:Smoking among some adults dropped dramatically in past three decades 2Health News:Smoking among some adults dropped dramatically in past three decades 3Health News:Smoking among some adults dropped dramatically in past three decades 4Health News:Smoking among some adults dropped dramatically in past three decades 5Health News:Smoking among some adults dropped dramatically in past three decades 6Health News:Poor sleep quality increases inflammation, community study finds 2Health News:Poor sleep quality increases inflammation, community study finds 3
... Monoclonal antibody method for HbA1c provides ... shows 99% agreement with the HPLC method(1) ... a CV of 2.6%* means your ... Program (NGSP) certified method, as recommended by ...
... Maximize your laboratorys ... and enhanced automated workflow ... high-throughput automated workstation now ... and immunoassay with specimen ...
The sole coagulation analyzer in the world that uses a unique dry reagent card....
... a manual hemostasis analyzer that is ... - PTs, aPTTs, thrombins, fibrinogens and ... low-volume testing, this analyzer is small ... offering time and labor saving benefits. ...
Medicine Products: