Navigation Links
Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting
Date:6/8/2008

the SB-509-401 study was safety, we also observed statistically significant and clinically relevant improvements in a number of quantitative measures of neurological health," said Edward Lanphier, Sangamo's president and CEO. "We believe that SB-509 represents a new therapeutic approach for diabetic neuropathy, designed to directly protect and possibly restore nerve function, in contrast to the current standard of care designed to address the pain associated with this condition. We are encouraged by the data so far and are swiftly moving forward to the next stage of clinical development with our ongoing Phase 2 clinical trials. We expect to have data from our double blind Phase 2 clinical trial (SB-509-601) available in the fourth quarter of this year."

About SB-509

SB-509 is an injectable formulation of a plasmid encoding a zinc finger DNA-binding protein transcription factor (ZFP TF(TM)) designed to upregulate the expression of the gene encoding vascular endothelial growth factor (VEGF-A). VEGF-A has been demonstrated to have direct neurotrophic and neuroprotective properties. In preclinical animal efficacy studies in a diabetic rat model (Diabetes, June 1, 2006; 55(6): 1847-1854), SB-509 has proven effective in protecting motor and sensory nerve function from disease-induced nerve damage.

About the SB-509 Clinical Program

Sangamo has three ongoing Phase 2 studies in diabetics with sensory/motor neuropathy:

Phase 2 study of SB-509 for mild to moderate DN (SB-509-601)

The clinical trial is a double-blind, placebo-controlled, repeat-dosing study designed to evaluate the clinical safety and clinical effects of repeat administration of SB-509 in diabetics with mild to moderate diabetic peripheral sensory motor neuropathy in the legs. The trial is being conducted at multiple sites and is fully enrolled; data is expected to be available in the fourth quarter of 2008.

Approximately 100 subjects have been enrolled into the
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs
2. Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting
3. Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of Knock-Out Cell Lines
4. Sangamo BioSciences Reports 2007 Fourth Quarter and Year-End Financial Results
5. Sangamo BioSciences Announces Completion of Enrollment of Phase 2 Clinical Trial of ZFP Therapeutic for Diabetic Neuropathy
6. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
7. Regado Biosciences Announces Publication in Circulation of Clinical Trial Results of REG1 Anticoagulation System
8. Magellan Biosciences Companies to Feature Automated Products and New Tests for MRSA at the American Society for Microbiology Meeting, Booth 743
9. Ardea Biosciences Presents Preclinical Data on RDEA119 Demonstrating Favorable Anti-Inflammatory Profile for Potential Use in Ulcerative Colitis
10. Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594
11. Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 31, 2015 The Physician-Patient Alliance for ... July 28, 2015, "Surviving Your Hospital Stay: Physician-Patient ... Patient Safety." A sentence was omitted ... "PPAHS is a member of the National ... more information on the National Coalition to Promote ...
(Date:7/31/2015)... TAMPA, Fla. , July 31, 2015 /PRNewswire/ ... announced today that it has made a structured ... -based company specializing in milling, micronization and ... investment will help grow Powdersize,s business while simultaneously ... solutions to Xcelience,s portfolio of capabilities. ...
(Date:7/31/2015)... July 31, 2015  Semler Scientific, Inc. (Nasdaq: ... services to healthcare insurers and physician groups, today reported ... 2015. "In the second quarter of ... revenue growth of 54%, quarter over quarter revenue growth ... installed base of FloChec® units of 18%," said Doug ...
Breaking Medicine Technology:Xcelience Makes Structured Cash Investment in Powdersize 2Xcelience Makes Structured Cash Investment in Powdersize 3Semler Reports Second Quarter 2015 Financial Results 2Semler Reports Second Quarter 2015 Financial Results 3Semler Reports Second Quarter 2015 Financial Results 4Semler Reports Second Quarter 2015 Financial Results 5Semler Reports Second Quarter 2015 Financial Results 6
(Date:8/2/2015)... ... August 03, 2015 , ... For many “would be” entrepreneurs, starting a new business can ... can’t afford to start a business.” Neither needs be a major obstacle. , The ... to start a business and be successful. The risks of starting a business can be ...
(Date:8/1/2015)... Winamac, In (PRWEB) , ... August 02, 2015 , ... ... this month which will help the continuity of care for patients at this natural ... afraid of the unknown," Clinic Director Mary Heal said. "Heather's role is vital to ...
(Date:8/1/2015)... ... ... wondered what “Karma” really means? Does it even exist? Can I change my Karma? Many ... birth to Hinduism, is one of the most ancient spiritual and mystical traditions on the ... wisdom of this heritage, Karma is a very real and powerful force in our lives; ...
(Date:8/1/2015)... ... August 01, 2015 , ... Tina Wilcoxson, owner of Freeport ... was given that honor by the National Retail Federation, the largest retail trade association ... one of three Maine business owners to be named as such. According to the ...
(Date:8/1/2015)... ... August 01, 2015 , ... On Tuesday, July 28th, Symantec ... are thought to have been behind the attack on Anthem Inc. which resulted in ... day exploits, watering hole attacks and spear phishing campaigns. , For Joe ...
Breaking Medicine News(10 mins):Health News:Newport Board Group, an Advisory Firm Serving Middle Market Companies, Releases a 5 Step Guide to Starting a Successful Business for Under $1,000 2Health News:Newport Board Group, an Advisory Firm Serving Middle Market Companies, Releases a 5 Step Guide to Starting a Successful Business for Under $1,000 3Health News:Newport Board Group, an Advisory Firm Serving Middle Market Companies, Releases a 5 Step Guide to Starting a Successful Business for Under $1,000 4Health News:Newport Board Group, an Advisory Firm Serving Middle Market Companies, Releases a 5 Step Guide to Starting a Successful Business for Under $1,000 5Health News:New Patient Advocate Enhances Natural Health Care 2Health News:Nithyananda Yoga Foundation to Conduct Global Webinar on Karma at No Charge on August 1st 2Health News:Local Retail Advocate Wins National Recognition 2Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 2Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 4
... that allows cancer to spread from one part of the ... understand the disease better. ,Jun-Lin Guan, a professor in ... Medicine at Cornell University, used a cultured cell line to ... cells to create a model system for cancer cells, which ...
... illnesses (SMI) are eleven times more at risk than ... was published in the recent issue of Archives of ... mentally ill person is at risk from being the ... severe mental illness, such as disorganized thought processes, impulsivity ...
... has called for a government probe into an Uttar ... reputed publications, The Lancet and the British Medical Journal. ... of our country will be questioned unless the Indian ... investigates the entire scientific activity of (Dr. Ram B.) ...
... heard about eating sensibly and exercising. The way to lose ... and feast// the next - the way our hunter-gatherer ancestors ... about nutrition and dieting, is the result of research by ... Ageing here., ,For several years Mattson has been fiddling ...
... of a grave nature and seems to be one of ... Children's Hospital Medical Center who had reported their findings in ... injuries sustained at home account for more than 2400 deaths ... from the National Vital Statistics System Mortality Data of USA ...
... The Central government of India plans to come out ... of technologies discovery by Indian universities //and research institutions ... ,The proposed legislation would give Indian universities and institutions ... CSIR the ability to stake claims on discoveries they ...
Cached Medicine News:Health News:Scientists Identify Cancer Pathway 2Health News:Patients Suffering From Severe Mental Diseases Are At Risk Of Being Crime Victims 2Health News:Research Fraud By Doctor – Probe Demanded 2Health News:Fasting, Feasting Your Way To Health 2
... new 4351 Intramuscular Lead is a unipolar lead ... 4351 lead has a ski needle design for ... designed with a fixed electrode length of 1 ... neurostimulator and is available in 35 cm length. ...
... AwareTM HIV-1/2 OMT test is a single ... for the,detection of antibodies to Human Immunodeficiency ... (HIV-2) in human oral,mucosal transudate specimens. It ... aid in the clinical diagnosis of HIV,infection. ...
... control available with intact red blood cells ... the lysing of the red blood cell. ... with an open-vial stability of 30 days ... when refrigerated. A1c-Cellular is appropriate for immunoassay ...
...
Medicine Products: