Navigation Links
Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting
Date:6/8/2008

measurement of the speed and amplitude of an applied electrical impulse or nerve conduction velocity (NCV) in both sensory and motor nerves is a method of assessing the integrity or health of the nerve. A broader approach to quantification of clinical benefit involves the use of one of the many available composite scoring systems. These include the Total Neuropathy Score (TNS) and the narrower Neuropathy Impairment Score in the Lower Limbs (NIS-LL). The NIS-LL is a validated instrument that can be used to measure a clinically meaningful change in the neurological status of patients with DN over time. NIS-LL includes measures of motor and sensory nerve heath as well as reflex testing and is a quantifiable score of neurologic exam. These three measurements have all been used as primary or secondary endpoints of clinical benefit in Phase 3 studies.

"We are very encouraged by the safety of SB-509 and the improvements that we have seen in subjects with mild to moderate DN up to six-months after administration of a single dose of SB-509," stated Dale Ando, M.D., Sangamo's vice president of therapeutic development and chief medical officer. "Particularly interesting are the encouraging and correlative gains observed in the NIS-LL and QST measurements of treated subjects which are independent and confirmatory. Both NIS-LL and QST have been used as end-points in previous pivotal large scale trials of other non-analgesic approaches for diabetic neuropathy. "

From a safety perspective, the Phase 1b data were consistent with previous observations that a single treatment of SB-509 was well tolerated and that no drug-related severe adverse events were observed. Injection site reactions were the most common adverse events reported and were mild and reversible. Importantly, subjects in the study were treated within the pharmacologically effective dose range that was demonstrated to be efficacious in preclinical animal studies.

"Although the primary end-point of
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs
2. Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting
3. Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of Knock-Out Cell Lines
4. Sangamo BioSciences Reports 2007 Fourth Quarter and Year-End Financial Results
5. Sangamo BioSciences Announces Completion of Enrollment of Phase 2 Clinical Trial of ZFP Therapeutic for Diabetic Neuropathy
6. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
7. Regado Biosciences Announces Publication in Circulation of Clinical Trial Results of REG1 Anticoagulation System
8. Magellan Biosciences Companies to Feature Automated Products and New Tests for MRSA at the American Society for Microbiology Meeting, Booth 743
9. Ardea Biosciences Presents Preclinical Data on RDEA119 Demonstrating Favorable Anti-Inflammatory Profile for Potential Use in Ulcerative Colitis
10. Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594
11. Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... and PITTSBURGH , July 27, 2015 /PRNewswire/ ... will hold its extraordinary general meeting of shareholders in connection ... PRGO ; TASE) at the Okura Hotel Amsterdam on Friday, ... Among other agenda items at the extraordinary ... approval, under article 2:107a of the Dutch Civil Code, of ...
(Date:7/27/2015)... , July 20, 2015 ... announced the addition of the "Cardiometabolic Drug ... Afrezza,s discounted pricing is in line with ... critical to the product,s commercial appeal. However, contraindications, ... Afrezza from gaining a sizeable share of the ...
(Date:7/27/2015)...  Linear accelerators used to treat patients with ... adequate space for the equipment itself, but also ... the size and complexity of the technology, full ... of a new vault constitutes a formidable undertaking ... patient treatment: with potential negative long-term effects for ...
Breaking Medicine Technology:Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 2Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 3Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 4Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 5Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 6Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 7Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 8Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 9Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 10Cardiometabolic Drug News Issue - Afrezza Aggressive Pricing Strategy View Playing Out 2Cardiometabolic Drug News Issue - Afrezza Aggressive Pricing Strategy View Playing Out 3Accelerating the Design Process for Cancer Treatment Centers 2Accelerating the Design Process for Cancer Treatment Centers 3
... 23, 2011 PharmacoFore, Inc., a privately held ... announced positive results from a Phase I human ... Molecular Delivery™ (Bio-MD™) product candidate, PF329.  Greg Sturmer, ... 2011 BIO Business Forum during the annual BIO ...
... Luminex Corporation (NASDAQ: LMNX ) has ... Most Innovative Company of the Year (for companies with ... Year for the MAGPIX System.  A record number of ... organizations from virtually all company sizes and industries.  In ...
Cached Medicine Technology:PharmacoFore, Inc. Announces Positive Results from a Phase I Clinical Study of Its Hydromorphone Bio-Activated Molecular Delivery™ System, and Upcoming Presentation at the 2011 BIO Business Forum During the Annual BIO International Convention in Was 2PharmacoFore, Inc. Announces Positive Results from a Phase I Clinical Study of Its Hydromorphone Bio-Activated Molecular Delivery™ System, and Upcoming Presentation at the 2011 BIO Business Forum During the Annual BIO International Convention in Was 3PharmacoFore, Inc. Announces Positive Results from a Phase I Clinical Study of Its Hydromorphone Bio-Activated Molecular Delivery™ System, and Upcoming Presentation at the 2011 BIO Business Forum During the Annual BIO International Convention in Was 4Luminex Corporation Named Most Innovative Company of the Year and Receives Business Innovation of the Year Award for MAGPIX® System 2Luminex Corporation Named Most Innovative Company of the Year and Receives Business Innovation of the Year Award for MAGPIX® System 3
(Date:7/27/2015)... ... July 28, 2015 , ... ... as the sports medicine provider for the entire school district including Anderson County ... ACHS Athletic Director Rick Sallee, “Student safety and well-being are a top priority ...
(Date:7/27/2015)... ... July 28, 2015 , ... The National Association of Professional ... VIP Woman of the Year Circle. She is recognized with this prestigious distinction for ... boasting more than 700,000 members and over 200 operating Local Chapters. , “I’m pleased ...
(Date:7/27/2015)... ... July 27, 2015 , ... Interactive health education is ... this year Wound Care Advantage beta launched Luvo University, an online ... Customized learning paths allow for clinicians, physicians, hyperbaric technicians and non-clinical staff ...
(Date:7/27/2015)... (PRWEB) , ... July 27, 2015 , ... ... transformed the science of the little-known and incurable disease, facioscapulohumeral muscular dystrophy (FSHD), ... American Academy of Neurology (AAN). The FSHD care guideline is published today. ...
(Date:7/27/2015)... ... ... Looking to brush up on all the things you should be doing ... enhanced its Dental webpage with new materials, including user-friendly, educational videos, to help members ... to offering our 3.8 million members tools and resources to help them keep a ...
Breaking Medicine News(10 mins):Health News:KORT Physical Therapy Named Sports Medicine Provider for Anderson County School System 2Health News:KORT Physical Therapy Named Sports Medicine Provider for Anderson County School System 3Health News:NAPW Inducts Joanne Saniewski, Principal of the Frontier School District's Big Tree Elementary, Into its VIP Woman of the Year Circle 2Health News:Wound Care Advantage Launches Luvo University An Online Hub For Wound Care Education and Training 2Health News:Wound Care Advantage Launches Luvo University An Online Hub For Wound Care Education and Training 3Health News:First-Ever FSHD Evidence-based Care Guideline Published by the American Academy of Neurology 2Health News:Thinking about a Dental Check-up? Check out Horizon Blue Cross Blue Shield of New Jersey’s Enhanced Website for a Dental Download of Helpful Information 2
... Leverages Personal Health Care Utilization and Employee Data to ... WHO: Daryl Ashley, senior vice president and general ... Benefits Administration for Workscape, a leading ... Will be a featured presenter in the "Getting Personal -- ...
... and anchor ... depth, ... SN) Endoscopy Division today announced the launch of the,BIORAPTOR 2.3 PK Suture ... is featured at Smith & Nephew Endoscopy,s booth,at the American Academy of ...
... Care,Spending May More Than Double as Hospital Capacity Declines And Baby Boomer ... ... of over 70,million aging baby boomers could overwhelm the U.S. health care ... the,Boom Bust Health Care?," by management consulting firm Tefen USA., A ...
... to Invest in Your Teeth, VOORHEES, N.J., March ... should be similar for 2007. Together with the,government,s economic ... in the pockets of most taxpayers this Spring, it,s ... vacations., But rather than getting away for a ...
... Associate at Kendle ... International, Inc., Joins Catalyst, CORAL GABLES, Fla., March 5 ... the,appointment of Patrick Kenny as Director - Corporate Clinical Compliance.,In ... and GCP compliance of the CROs, clinical contractors and,clinical trial ...
... 1999,OurHealthNetwork.com ( http://www.OurHealthNetwork.com ) has been the,Internet,s leading ... board- certified podiatrists now introduces an exclusive line ... orthotics that not only,provide relief to those who ... their,lifestyles and shoe styles. Now for the first ...
Cached Medicine News:Health News:Upcoming Business Health Agenda 2008 Features Workscape Executive 2Health News:Smith & Nephew Endoscopy's BIORAPTOR(TM) 2.3 PK Suture Anchor Provides Secure Repair for Shoulder, Hip Instability 2Health News:Smith & Nephew Endoscopy's BIORAPTOR(TM) 2.3 PK Suture Anchor Provides Secure Repair for Shoulder, Hip Instability 3Health News:Smith & Nephew Endoscopy's BIORAPTOR(TM) 2.3 PK Suture Anchor Provides Secure Repair for Shoulder, Hip Instability 4Health News:New Study: Aging Baby Boomers Could Overwhelm U.S. Health Care System by 2017, Unless Decisive Action Is Taken 2Health News:New Study: Aging Baby Boomers Could Overwhelm U.S. Health Care System by 2017, Unless Decisive Action Is Taken 3Health News:New Study: Aging Baby Boomers Could Overwhelm U.S. Health Care System by 2017, Unless Decisive Action Is Taken 4Health News:Smile When You Get that Refund 2Health News:Catalyst Pharmaceutical Partners, Inc. Names Director - Corporate Clinical Compliance 2Health News:Catalyst Pharmaceutical Partners, Inc. Names Director - Corporate Clinical Compliance 3Health News:Catalyst Pharmaceutical Partners, Inc. Names Director - Corporate Clinical Compliance 4Health News:Unique Line of Custom-Made Orthotics for Sandals and Clogs Cater to Style-Minded Foot Pain Sufferers 2
Well established test for children but suitable for disabled people, those with learning difficulties or patients who do not share a common language with the examiner....
The FLEXI-CUT Directional Debulking System is Abbott Vascular's latest atherectomy catheter designed to enhance performance and ease-of-use....
This test displays normal protan, deutan and tritan colors, differentiation is stronger in the red/green., ,Significant tritan defects may be detected if used in conjunction with the Ishihara. Th...
The New Vantage Plus. The PLUS gives you: ,P Premium intelligent optics ,L Lighter weight and brighter images ,U Unique wireless patented technology ,S Smaller and more compact size ...
Medicine Products: