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Sangamo BioSciences Announces Presentation of Clinical Data Demonstrating Functional Control of Viremia in HIV-Infected Subjects Treated with SB-728-T
Date:9/12/2013

important and suggest that an immunological approach to control of HIV infection is obtainable," commented Rafick-Pierre Sekaly, Ph.D., Co-Director & Chief Scientific Officer of the Vaccine & Gene Therapy Institute of Florida (VGTI Florida), and a collaborator on the study.  "SB-728-T treatment results in an unprecedented and durable increase in CD4+ cells primarily due to the expansion of central memory cells - CD4+ T-cell types that are vital for the successful reconstitution of the immune system in HIV-infected individuals.  This enables functional control of virus and effects on the latent reservoir of HIV-infected cells that cannot be cleared by ART."

Central and transitional memory T-cells remember previously encountered foreign invaders, such as viruses or bacteria.  These cells can survive in the body for the individual's lifetime and reactivate when they re-encounter the same antigen.  On reactivation they produce a faster and stronger immune response than the previous encounter. SB-728-T seems to both expand the total memory pool and, by CCR5 modification, protect a proportion of that pool from HIV entry, suggesting that SB-728-T treatment has the potential to durably reconstitute and protect an effective immune system in HIV-infected individuals.

"We are amassing a body of data suggesting that SB-728-T treatment can potentially enable attacks on HIV infection from several angles," said Geoff Nichol, M.B., Ch.B., Sangamo's executive vice president of research and development. "Our aim is to provide a protected reservoir of immune memory cells to replenish the cells killed by HIV and to generate an effective immune response against the virus and opportunistic infections.  Some HIV-infected individuals, so-called 'elite controllers,' can accomplish this without drug intervention. These indivi
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SOURCE Sangamo BioSciences, Inc.
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