Navigation Links
Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant T Cells
Date:6/30/2008

gher in mice in the presence of HIV infection (p=0.008). In a second experiment it was determined that 50 days after infection, mice given the ZFN- modified cells had increased numbers of CD4 cells and a statistically significant reduction in viral load in their peripheral blood (P<0.001) compared to mice given control cells. These data suggest that, in the presence of HIV, the ZFN-modified cells have a selective advantage allowing them to evade infection and destruction leaving them able fight opportunistic infections and HIV itself.

About HIV/AIDS and CCR5

HIV stands for Human Immunodeficiency Virus. HIV infection kills or impairs cells of the immune system, progressively destroying the body's ability to fight infections and certain cancers resulting in AIDS (Acquired Immune Deficiency Syndrome). Individuals diagnosed with AIDS are susceptible to life-threatening diseases called opportunistic infections, which are caused by microbes that usually do not cause illness in healthy people. According to Worldaidsday.org, over 3 million people were infected with HIV in 2005. There are now over 40 million people living with HIV and AIDS worldwide.

CCR5 is the chemokine receptor that HIV uses as a co-receptor to gain entry into immune cells. CCR5 is perhaps the most important of the known co- receptors for HIV, since the most commonly transmitted strains of HIV are strains that bind to CCR5 -- so-called "R5" strains. A small fraction of the population carries a mutation in their CCR5 gene, called the delta32 mutation. This mutated version of the gene results in a truncated CCR5 protein which cannot be used by HIV as a co-receptor. Individuals that have mutant delta 32 versions of both of their CCR5 genes are resistant to infection by R5 HIV strains.

About Sangamo

Sangamo BioSciences, Inc. is focused on the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. The most advanced ZFP Therape
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting
2. Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs
3. Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting
4. Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of Knock-Out Cell Lines
5. Sangamo BioSciences Reports 2007 Fourth Quarter and Year-End Financial Results
6. Sangamo BioSciences Announces Completion of Enrollment of Phase 2 Clinical Trial of ZFP Therapeutic for Diabetic Neuropathy
7. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
8. Ardea Biosciences Reports Additional Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating Up to 1.9 Log Reduction in Plasma Viral Load with Once-Daily Dosing
9. Pressure BioSciences, Inc. Announces $850,000 NIH SBIR Phase II Award for the Development of a New PCT-dependent System for Improved Biomarker Discovery, Diagnostics, and Drug Discovery
10. Neurocrine Biosciences Completes Petal Study Treatment Phase for Endometriosis
11. Regado Biosciences Announces Publication in Circulation of Clinical Trial Results of REG1 Anticoagulation System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... MarketResearchreports.biz presents this most up-to-date ... (Rapid-Acting, Short-Acting, Intermediate-Acting, Long-Acting, Premixed, And Modern and Human ... Forecast (Value and Volume), 2013 - 2019: Market Size, ... at an exponential rate worldwide, has become a serious ... cause of death of people between 20 years and ...
(Date:7/31/2014)... , 31 juli 2014 De Pfizer Clinical ... rekruteringscampagne voor gezonde vrijwilligers van Japanse komaf voor medewerking ... gevestigde PCRU is één van twee onderzoekseenheden ... ideaal levens te verbeteren door de ontdekking en ontwikkeling ... PCRU op zoek naar mannen en vrouwen van Japanse ...
(Date:7/30/2014)... 2014  There is still time to share ... 10th Annual Institute for Supply Management ® ... Supply Management is open for submissions.  The annual ... importance of supply management by recognizing supply management ... management practices.  Entries are due August 22, 2014. ...
Breaking Medicine Technology:The Global and China Insulin Market is Expected to Grow at a CAGR of 6.1% From 2013 to 2019 to Reach USD 32.24 Billion in 2019 2The Global and China Insulin Market is Expected to Grow at a CAGR of 6.1% From 2013 to 2019 to Reach USD 32.24 Billion in 2019 3The Global and China Insulin Market is Expected to Grow at a CAGR of 6.1% From 2013 to 2019 to Reach USD 32.24 Billion in 2019 4The Global and China Insulin Market is Expected to Grow at a CAGR of 6.1% From 2013 to 2019 to Reach USD 32.24 Billion in 2019 5The Global and China Insulin Market is Expected to Grow at a CAGR of 6.1% From 2013 to 2019 to Reach USD 32.24 Billion in 2019 6The Global and China Insulin Market is Expected to Grow at a CAGR of 6.1% From 2013 to 2019 to Reach USD 32.24 Billion in 2019 7The Global and China Insulin Market is Expected to Grow at a CAGR of 6.1% From 2013 to 2019 to Reach USD 32.24 Billion in 2019 8Gezonde vrijwilligers van Japanse komaf gezocht voor deelname aan Fase I klinisch onderzoek 2Institute for Supply Management, Michigan State University to recognize companies with excellent supply management practices 2
(Date:7/31/2014)... life but no matter how hard you hit, your ... be said of highly treatment-resistant cancers, such as head ... cancer cells repair themselves, survive and thrive. Head and ... the world, but the late detection and treatment resistance ... University of Michigan researchers have found that a particular ...
(Date:7/31/2014)... 2014 Perhaps some people are unaware of ... old from the first day when we were born on ... downs during their whole life. Some people may live without ... it is not necessary for people to worry about that. ... Auto, a famous China automobile manufacturer , is one ...
(Date:7/31/2014)... July 31, 2014 1Heart Business ... round to CEO Belina Calderon’s group of companies ... medical billing, 1Heart Caregiver Services, L.A. Jobs Employment ... applauds the most recent resource speaker and trainer ... Bowie for sharing his expertise and knowledge in ...
(Date:7/31/2014)... 2014 Eden Lew has been ... - Crawford Technologies" Scholarship through EDSF ... to honor the contributions Chuck Forman made throughout ... Chuck lost his battle with cancer on October ... we are thrilled to see her receive the ...
(Date:7/31/2014)... 2014 Care Communications, Inc., (CARE) a ... has received the Elite Award for “Recruitment, Selection and ... of twelve elite awards presented as part of ... For” 2014 awards competition. This marks the seventh ... in the competition. CARE has also been chosen as ...
Breaking Medicine News(10 mins):Health News:FodayAuto.com: Do Not Be Afraid of Getting Old 2Health News:1Heart Business Academy Applauds Resource Speaker and Trainer Los Angeles Area Chamber of Commerce Ambassador Glenn Bowie 2Health News:1Heart Business Academy Applauds Resource Speaker and Trainer Los Angeles Area Chamber of Commerce Ambassador Glenn Bowie 3Health News:1Heart Business Academy Applauds Resource Speaker and Trainer Los Angeles Area Chamber of Commerce Ambassador Glenn Bowie 4Health News:Eden Lew Recipient of 2014 EDSF Scholarship Honoring Chuck Forman 2Health News:Eden Lew Recipient of 2014 EDSF Scholarship Honoring Chuck Forman 3Health News:Care Communications, Inc. Named an Elite Award Winner Among Top Chicago Employers 2
... Healthcare and personal care items shipped to QualComm Stadium and other ... for distribution to evacuees, Prescription delivery service from CVS to Qualcomm ... ... filled, WOONSOCKET, R.I., Oct. 24 CVS/pharmacy, the retail,division of CVS Caremark ...
... good to eat," they,re hoping for candy -- and ... but also a tradition that causes,concern about the effects ... and common sense, however, parents can help protect their ... of sugar in Halloween candy is stunning," said Dr. ...
... early gained some symptom relief, study found , , WEDNESDAY, ... month,s worth of inhaler medicine may have lessened rescue ... 11, 2001, World Trade Center attacks, according to new ... anti-inflammatory medicines commonly used for the treatment of asthma. ...
... Washington, D.C.More than three quarters of adults living in ... factor for stroke, but those who are poor do ... wealthier counterparts. In an effort to address these disparities ... NIH,s National Institute of Neurological Disorders and Stroke (NINDS) ...
... advice in approaching decisions about life, career, having a ... of the Institute for Operations Research and the Management ... Research Professor of Decision Sciences at the Fuqua School ... A Practical Guide to Making Better Decisions, a Harvard ...
... messages from meaningless noise could be an early sign ... of Medicine researchers. , The study this month in ... diagnosed with prodromal symptoms meaning they exhibited early warning ... alterations, or misinterpretation of social cues. , Participants in ...
Cached Medicine News:Health News:CVS/pharmacy Donates More Than $300,000 in Supplies to Aid Fire Relief Efforts in California 2Health News:Parents: With Halloween Candy, Focus on Choice and Time to Prevent Teeth Decay 2Health News:Inhaler Eased Lung Problems in 9/11 Workers 2Health News:Inhaler Eased Lung Problems in 9/11 Workers 3Health News:Georgetown leads major effort to combat disparities in DC stroke care 2Health News:Georgetown leads major effort to combat disparities in DC stroke care 3Health News:Trouble deciding? 2Health News:Trouble deciding? 3
Inquire...
One Pair of Knife Raising Blocks to move blade up 1 inch for adpatation of a freezing stage....
CO2 gas object holder and knife freezer for the 8000 Series Sliding Microtome...
Quick Release Holder designed for the 8000 Series Microtome to hold hardboard squares....
Medicine Products: