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SYNTAX Analysis Finds Treatment With TAXUS(R) Express2(R) Stent System More Cost Effective Than Bypass Surgery in Patients With Complex Coronary Artery Disease
Date:5/20/2009

ization associated with PCI and CABG surgery in patients in 11 European countries and the U.S. who qualified for one or the other revascularization option. The results indicated a short-term benefit for PCI versus CABG surgery, with no significant difference at one year, but with a gain in quality adjusted life years (QALY) of 0.02 in favor of PCI.

The analysis also included a detailed calculation of total medical costs at one year for all patients treated in the U.K., the country with the largest cohort of patients. Total costs included the initial procedure, all hospitalizations, repeat procedures and medication. Although initial procedure costs were similar (4,201 pounds Sterling for PCI vs. 4,246 pounds Sterling for CABG), total medical costs for PCI were 25 percent lower than CABG at one year (8,295 pounds Sterling PCI vs. 11,101 pounds Sterling CABG, p<0.001). The lower medical costs coupled with the net improvement in quality of life resulted in PCI as the dominant treatment strategy at one year.

Results further showed that although the average length of hospital stay varied by country, CABG patients were hospitalized on average an additional 7.8 days compared to PCI patients (13.7 vs. 5.9 days, including pre- and post-procedure).

SYNTAX is the first randomized, controlled clinical trial to compare PCI using the TAXUS(R) Express2(R) Paclitaxel-Eluting Coronary Stent System to CABG surgery in patients with left main disease and/or significant narrowing of all three coronary arteries (three-vessel disease). These complex patients are traditionally treated with CABG surgery and have been excluded from most prior drug-eluting stent clinical trials. The SYNTAX trial provides important data related to the treatment of these complex patients and should help physicians make more informed treatment decisions.

It has been previously reported that one-year SYNTAX data demonstrated comparable
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SOURCE Boston Scientific Corporation
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