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STELARA(TM) Shows Greater Efficacy Than Etanercept for Treatment of Moderate to Severe Plaque Psoriasis: Phase 3 Comparator Study Published in The New England Journal of Medicine
Date:1/14/2010

ere randomized to receive subcutaneously administered STELARA or etanercept.  Patients randomized to receive STELARA received 45 mg or 90 mg doses at weeks 0 and 4.  Patients in the etanercept group received twice-weekly doses of 50 mg for 12 weeks.  The primary endpoint of the study was the proportion of patients who achieved PASI 75 at week 12.  At week 12, patients in the etanercept group who were classified as non-responders (i.e., had moderate, marked or severe psoriasis) received 90 mg of STELARA at weeks 16 and 20.  STELARA non-responders received one additional dose of STELARA at week 16.  Treatment was interrupted for all patients who had cleared, minimal or mild psoriasis at the end of week 12, and all patients were retreated with 45 or 90 mg STELARA when their disease worsened to moderate or worse.  

About Psoriasis

Psoriasis is a chronic, immune-mediated disease that results from the overproduction of skin cells, resulting in their accumulation on the surface of the skin, which causes red, scaly plaques that may itch and bleed.  It is estimated that approximately 7.5 million people in the United States are living with psoriasis and nearly one-quarter of those people have cases that are considered moderate to severe.

About STELARA (ustekinumab)

STELARA, a human interleukin (IL)-12 and IL-23 antagonist, is approved for the treatment of adult patients (18 years or older) with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy.  IL-12 and IL-23 are naturally occurring proteins that are believed to play a role in psoriasis.  For more information about STELARA, visit

SOURCE Centocor Ortho Biotech Inc.
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