Navigation Links
STELARA(TM) Shows Greater Efficacy Than Etanercept for Treatment of Moderate to Severe Plaque Psoriasis: Phase 3 Comparator Study Published in The New England Journal of Medicine
Date:1/14/2010

ere randomized to receive subcutaneously administered STELARA or etanercept.  Patients randomized to receive STELARA received 45 mg or 90 mg doses at weeks 0 and 4.  Patients in the etanercept group received twice-weekly doses of 50 mg for 12 weeks.  The primary endpoint of the study was the proportion of patients who achieved PASI 75 at week 12.  At week 12, patients in the etanercept group who were classified as non-responders (i.e., had moderate, marked or severe psoriasis) received 90 mg of STELARA at weeks 16 and 20.  STELARA non-responders received one additional dose of STELARA at week 16.  Treatment was interrupted for all patients who had cleared, minimal or mild psoriasis at the end of week 12, and all patients were retreated with 45 or 90 mg STELARA when their disease worsened to moderate or worse.  

About Psoriasis

Psoriasis is a chronic, immune-mediated disease that results from the overproduction of skin cells, resulting in their accumulation on the surface of the skin, which causes red, scaly plaques that may itch and bleed.  It is estimated that approximately 7.5 million people in the United States are living with psoriasis and nearly one-quarter of those people have cases that are considered moderate to severe.

About STELARA (ustekinumab)

STELARA, a human interleukin (IL)-12 and IL-23 antagonist, is approved for the treatment of adult patients (18 years or older) with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy.  IL-12 and IL-23 are naturally occurring proteins that are believed to play a role in psoriasis.  For more information about STELARA, visit

SOURCE Centocor Ortho Biotech Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Iomai Trial Shows 100 Percent Immune Response in Elderly Subjects Vaccinated With Novel Travelers Diarrhea Patch Vaccine
2. Study Shows Combination Therapy Incorporating AVODART(R) and Tamsulosin Provides Continuous Symptom Improvement Over 2 Years
3. Largest Study to Date Shows Significant Reductions in Risks of Blood Clots and Reintervention With CYPHER(R) Sirolimus-eluting Coronary Stent Compared to Taxus Stent
4. Kosans Second-Generation Hsp90 Inhibitor, Alvespimycin, Shows 42% Clinical Benefit in Phase 1 HER2-Positive Metastatic Breast Cancer Trial
5. Study Shows Plasma-Derived Human Thrombin Equivalent to Bovine Thrombin in Achieving Hemostasis in Surgery
6. Cleveland Clinic Study Shows the Diabetes Drug Pioglitazone Reduces Risk of Death, Heart Attack and Stroke, but Increases Risk of Heart Failure
7. New Data From Large Safety Analysis of MYCAMINE Shows Favorable Clinical Safety Profile
8. Feeling Anxious or Distracted? New Research Shows a Cup of Tea Could Help
9. New Study Shows Once-Monthly Boniva(R) is as Clinically Effective as Once-Weekly Fosamax(R) at Increasing Bone Mineral Density in Postmenopausal Women With Osteoporosis
10. Study Shows Vasopressin Receptor Antagonist VAPRISOL(R) (Conivaptan Hydrochloride Injection) Significantly Increased Serum Sodium Concentration in Patients with Euvolemic & Hypervolemic Hyponatremia
11. Newly Published Phase II Study Shows the Investigational Drug Vandetanib Prolongs Progression-Free Survival in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... , Jan. 15, 2014 The Cadence Fitness & ... Center by the Medical Fitness Association, a non-profit organization ... their full potential. The Cadence Fitness & Health Center ... suburbs and second in the Chicagoland area. ...
(Date:1/15/2014)... Pharmaceuticals International, Inc. (NYSE: VRX and ... the Hart-Scott-Rodino Antitrust Improvements Act of 1976 ("HSR") with ... indirect wholly-owned subsidiary, Sapphire Subsidiary Corp. ("Purchaser"), for all ... Medical, Inc. (NASDAQ: SLTM ) ("Solta") at ...
(Date:1/15/2014)...  A novel wearable injector slightly larger than an Oreo cookie ... self-inject prescription drugs in the large doses required to treat ... deficiencies, and genetic disorders.  An emerging biologic ... according to analysts.   Many of these drugs will require a ...
Breaking Medicine Technology:Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2
(Date:4/17/2014)... University of California, San Diego School of Medicine report ... suffered a recent major loss are more likely to ... The study is published in this month,s issue of ... Because compassionate behaviors are associated with better health and ... into ways to improve the outcomes of individuals whose ...
(Date:4/17/2014)... the April issue of Immunity , Kevin J. ... Research, says it,s time to take a fresh look ... sepsis, which kills millions worldwide every year, including more ... into the bloodstream to fight an injury or infection ... maintaining good health without inflammation, wounds and infections ...
(Date:4/17/2014)... A Northwestern University synthetic biology team has created ... create programmable therapeutics that could travel the body ... disease. , Engineering cell-based, biological devices that monitor ... in clinical synthetic biology. However, no existing technology ... a patient,s physiological state and respond in a ...
(Date:4/17/2014)... MAYWOOD, Il. (April 17, 2014) Doctors who ... disease called lymphangioleiomyomatosis (LAM) can face an agonizing ... progression of the disease and help relieve shortness ... lung transplants, and sirolimus can cause potentially fatal ... said pulmonologist Dr. Daniel Dilling, medical director of ...
(Date:4/17/2014)... YORK, NY (April 16, 2014) The cause of ... a new study proposes that neurons may be mistaken ... immune system, similar to the way autoimmune diseases like ... the body,s cells. The study was published April 16, ... a new, and likely controversial, idea in Parkinson,s disease; ...
Breaking Medicine News(10 mins):Health News:The ilk of human kindness 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Building 'smart' cell-based therapies 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:Is Parkinson's an autoimmune disease? 2
... the nation,s largest independent behavioral health and wellness ... Web site was honored with an eHealthcare ... Conference held November 10-12, 2008 in Orlando, FL. ... Award for Best Site Design for the second ...
... first half of 2009.SAN DIEGO, Jan. 6 Amira ... candidate for the treatment and control of inflammatory and ... on target for submission of an IND to the ... the successful completion of Good Laboratory Practices (GLP) toxicity ...
... available in French . , Montreal, ... risk delivering aggressive kids according to a new Canada-Netherlands ... . While previous studies have shown that smoking during ... who light up during pregnancy can predispose their offspring ...
... MOUNT VERNON, N.Y., Jan. 6 For over ... Prasad has,helped thousands of people including many celebrities ... innovative and highly effective treatment,program. His program combines ... with his trademark Turning Point Treatments to help ...
... and Benzoyl Peroxide in a Single Product; Performs ... 6 Galderma Laboratories, L.P. today announced the ... 0.1% / 2.5%, the first and only, once-daily, ... adapalene, and benzoyl peroxide, a well-known antimicrobial with ...
... (Nasdaq: COWN ) announced today that Christine Arnold ... care and health care service providers. Ms. Arnold joins Cowen ... from 1999 to 2008. She was previously employed by ... services. Between 2000 and 2008, she has consistently ranked ...
Cached Medicine News:Health News:ValueOptions(R) Behavioral Health and Wellness Web Site Wins eHealthcare Leadership Award for Best Site Design Second Year in a Row 2Health News:Amira Announces the Successful Completion of GLP Toxicity Studies for a Novel DP2 Antagonist. 2Health News:Smoking during pregnancy fosters aggression in children 2Health News:Stop Smoking in Three Sessions 2Health News:Galderma Announces Availability of Epiduo(TM) Gel, the First and Only Combination Treatment with a Retinoid and Benzoyl Peroxide to Treat Acne 2Health News:Galderma Announces Availability of Epiduo(TM) Gel, the First and Only Combination Treatment with a Retinoid and Benzoyl Peroxide to Treat Acne 3Health News:Galderma Announces Availability of Epiduo(TM) Gel, the First and Only Combination Treatment with a Retinoid and Benzoyl Peroxide to Treat Acne 4Health News:Cowen Adds Health Care Service Analyst to Equity Research Department 2
CCR Medical conventional laryngoscopes....
... Original LMA™ Airway., ,Launched in 1988, ... use is now standard practice in general ... worldwide the LMA Classic™ is a safe ... ,The LMA Classic™ can be used ...
... , ,Developed for cardiopulmonary resuscitation and ... LMA Fastrach™ has been designed to facilitate ... neck. The LMA Fastrach™ allows continuous ventilation ... emergency teams worldwide including NASA for its ...
... the production of airway management ... integrated solution to all your ... Portex Soft Seal Laryngeal Mask ... this wide portfolio of products ...
Medicine Products: