Navigation Links
STELARA(TM) Shows Greater Efficacy Than Etanercept for Treatment of Moderate to Severe Plaque Psoriasis: Phase 3 Comparator Study Published in The New England Journal of Medicine
Date:1/14/2010

Area and Severity Index (PASI 75) at week 12, the primary endpoint, compared with 57 percent of patients receiving subcutaneous injections of 50 mg etanercept twice per week for 12 weeks (P = 0.01 for STELARA 45 mg; P < 0.001 for STELARA 90 mg, each compared with etanercept).  Onset of clinical response appeared more rapidly among STELARA-treated patients, with higher numbers of patients achieving PASI 75 by week 8 compared with patients receiving etanercept.  

Investigators also reported that a greater proportion of patients receiving STELARA achieved a marked improvement in psoriasis as assessed by PASI 90 response, or nearly complete clearance of psoriasis.  At week 12, 36 percent of patients receiving STELARA 45 mg and 45 percent of patients receiving STELARA 90 mg achieved PASI 90 compared with 23 percent of patients receiving etanercept (P < 0.001 for each comparison versus etanercept).  Moreover, a greater proportion of patients in both the STELARA 45 mg and 90 mg treatment groups achieved a Physician Global Assessment (PGA) score of "cleared" or "minimal" (65 percent and 71 percent, respectively) compared with patients in the etanercept treatment group (49 percent) (P < 0.001 for each comparison versus etanercept).

Patients who had an inadequate response to etanercept, as measured by PGA score (classified as moderate, marked or severe psoriasis at week 12), received one injection of STELARA 90 mg at weeks 16 and 20.  At week 28, investigators reported that 49 and 23 percent of patients who failed to respond to etanercept and who crossed over to STELARA achieved PASI 75 and PASI 90, respectively.

In addition, patients classified as responders (having a PGA score of cleared, minimal or mild) at week 12 discontinued therapy until recurrence of psoriasis (PGA of moderate or greater).  In these patients, the median length of time to disease recurrence was l
'/>"/>

SOURCE Centocor Ortho Biotech Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Iomai Trial Shows 100 Percent Immune Response in Elderly Subjects Vaccinated With Novel Travelers Diarrhea Patch Vaccine
2. Study Shows Combination Therapy Incorporating AVODART(R) and Tamsulosin Provides Continuous Symptom Improvement Over 2 Years
3. Largest Study to Date Shows Significant Reductions in Risks of Blood Clots and Reintervention With CYPHER(R) Sirolimus-eluting Coronary Stent Compared to Taxus Stent
4. Kosans Second-Generation Hsp90 Inhibitor, Alvespimycin, Shows 42% Clinical Benefit in Phase 1 HER2-Positive Metastatic Breast Cancer Trial
5. Study Shows Plasma-Derived Human Thrombin Equivalent to Bovine Thrombin in Achieving Hemostasis in Surgery
6. Cleveland Clinic Study Shows the Diabetes Drug Pioglitazone Reduces Risk of Death, Heart Attack and Stroke, but Increases Risk of Heart Failure
7. New Data From Large Safety Analysis of MYCAMINE Shows Favorable Clinical Safety Profile
8. Feeling Anxious or Distracted? New Research Shows a Cup of Tea Could Help
9. New Study Shows Once-Monthly Boniva(R) is as Clinically Effective as Once-Weekly Fosamax(R) at Increasing Bone Mineral Density in Postmenopausal Women With Osteoporosis
10. Study Shows Vasopressin Receptor Antagonist VAPRISOL(R) (Conivaptan Hydrochloride Injection) Significantly Increased Serum Sodium Concentration in Patients with Euvolemic & Hypervolemic Hyponatremia
11. Newly Published Phase II Study Shows the Investigational Drug Vandetanib Prolongs Progression-Free Survival in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2015)... British Columbia , May 26, 2015 /PRNewswire/ ... announced today that it has filed a provisional ... Trademark Office ("USPTO") relating to the treatment of ... natural cannabinoid compounds developed by InMed. ... Chief Scientific Officer, commented, "We are excited to ...
(Date:5/22/2015)... 22, 2015  Research and Benchmarking firm, Best ... Medical Affairs Roundtable on Thursday, May 28th ... roundtable to discuss "Medical Affairs, Role in Health ... Medical Affairs Consortium provides Medical Affairs leaders with ... challenges they face. The consortium has developed a ...
(Date:5/22/2015)... mayo de 2015 Dipexium Pharmaceuticals, ... farmacéutica de fase tardía centrada en el ... 0.8%), y colaboradores de investigación clínica, han ... el diseño innovador de los ensayos pivotales ... evalúan Locilex®, su nuevo péptido de antibiótico ...
Breaking Medicine Technology:InMed Pharmaceuticals Files Provisional Patent Covering Novel Compounds for Treating Epidermolysis Bullosa Simplex (EBS) 2InMed Pharmaceuticals Files Provisional Patent Covering Novel Compounds for Treating Epidermolysis Bullosa Simplex (EBS) 3Best Practices Sixth Medical Affairs Consortium Roundtable to Focus on Health Economics & Outcomes Research 2Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 2Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 3Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 4Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 5Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 6
(Date:5/25/2015)... According to the National Library of Medicine, one in ... eye disease. The National Library of Medicine also states that ... , a rare disorder that causes sporadic muscle behavior or ... two diseases are more than a statistic – they’re a ... with his new autobiography “ The Way I See ...
(Date:5/25/2015)... City, NY (PRWEB) May 26, 2015 ... honors Laquanis Hooker as a 2015-2016 inductee into its ... recognized with this prestigious distinction for leadership in dentistry. ... professional women, boasting more than 700,000 members and over ... welcome Laquanis into this exceptional group of professional women,” ...
(Date:5/25/2015)... (PRWEB) May 25, 2015 World Patent ... products, launches The Preventer, a home patent that aims ... of fire. , "House fires cost the United States ... Cooper, CEO and Creative Director of World Patent ... result from homes that have no alarmed protection. With ...
(Date:5/25/2015)... 25, 2015 24Hr HomeCare is proud ... Brenneman-Slay, Co-Founder & COO, and Ryan Iwamoto, Co-Founder & ... Of The Year® 2015 Awards in Greater Los Angeles. ... demonstrate excellence in innovation, financial performance, and a personal ... the core of the ongoing success of our organization,” ...
(Date:5/25/2015)... 25, 2015 Stanley Consultants ... for design of the wastewater treatment expansion ... received a National Recognition Award from the American Council ... ACEC – Iowa. Competitions held by the organization ... $50.2 million expansion is Iowa City’s largest public works ...
Breaking Medicine News(10 mins):Health News:Joseph K. Chan Finds Faith from Disability in New Autobiography 2Health News:National Association of Professional Women Inducts Dr. Laquinas Hooked, D.D.S. of General Dentist, Into its VIP Professional Woman of the Year Circle 2Health News:Home Maintenance Causes House Fires? World Patent Marketing Introduces the Best Home Patent to Prevent Fire Accidents 2Health News:Home Maintenance Causes House Fires? World Patent Marketing Introduces the Best Home Patent to Prevent Fire Accidents 3Health News:24Hr HomeCare Co-Founders Named Finalists for EY Entrepreneur of the Year 2015 Awards 2Health News:Stanley Consultants’ Expansion of Iowa City Wastewater Treatment Plant Wins National Award 2Health News:Stanley Consultants’ Expansion of Iowa City Wastewater Treatment Plant Wins National Award 3
... July 10 The American people continue to move to the pro-life ... Knights of Columbus and Marist Poll. , , The poll mirrored ... than as pro-choice, and that the vast majority of Americans favor restricting ... , 86% of Americans ...
... 10 /PRNewswire-FirstCall/ - Hard to Treat Diseases (HTDS.PK) www.htdsmedical.com ... A Vaccine of 2009 was delivered to India, by the ... India this year by the company. The first batch was ... are recommended to receive Hepatitis A vaccine, including people at ...
... kicking motion yields surprising clues as to why , FRIDAY, ... have different patterns of injuries, and now U.S. researchers think ... examine the kicking motion in male and female soccer players, ... finding that could help prevent injuries in the future. , ...
... America, Inc., a leading medical diagnostic instrument manufacturer ... of Jim Cusack as Director of Business Development ... of Marketing & Medical Affairs, Sysmex America. ... the company,s existing business partnerships and in identifying ...
... Surfers, cancer survivors and supporters will gather ... with a special purpose: to show their support for the fight ... they will place their surfboards in the sand, one-by-one, nose-to-tail, with ... The line will start at Scripps Pier and continue down La ...
... Boston University School of Medicine (BUSM) and collaborators have ... ,EUK-400 series, which could someday be used to prevent ... brains of radiological terrorism victims. The findings, which appear ... Biological Inorganic Chemistry , describe new agents which can ...
Cached Medicine News:Health News:New Poll Shows Americans Continuing to Move Toward Pro-Life Position on Abortion 2Health News:Hard To Treat Diseases (HTDS.PK) Completes India Order 2Health News:Hard To Treat Diseases (HTDS.PK) Completes India Order 3Health News:Soccer Injuries Differ by Gender 2Health News:Sysmex America Names Industry Veteran to Business Development Post 2Health News:Moores UCSD Cancer Center Luau and Longboard Invitational Hosts Survivor Beach Aug. 9 2Health News:Moores UCSD Cancer Center Luau and Longboard Invitational Hosts Survivor Beach Aug. 9 3Health News:New oral agents may prevent injury after radiation exposure 2
Sandhill Scientific offers a comprehensive selection of solid state and water perfused catheters for both adult & pediatric applications.Contact Sandhill Scientific for full details...
... water perfused manometric catheters for ... diagnostic tests. All Medtronic Water ... clear, medical grade PVC tubing. ... esophagus you will find a ...
Esophageal Stylet for LATITUDE® Air-Charged Catheter...
Anorectal Stylet for LATITUDE® Air-Charged Catheter...
Medicine Products: