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SRI International and PhenoMatriX Collaborate to Develop Platin-Based Chemotherapies
Date:12/2/2010

MENLO PARK, Calif., Dec, 2, 2010 /PRNewswire/ -- SRI International, an independent nonprofit research and development organization, announced today that it is collaborating with PhenoMatriX (PMX), a biotechnology company, on the development of platin-based chemotherapies.  Platin-based drugs such as cisplatin and related analogues are used to treat a variety of cancers and have served as major weapons against solid tumors and other difficult-to-treat cancers since the 1970s.  Cancer is the leading cause of death worldwide.  Although 861 new cancer medicines and vaccines were in development in 2009 (PhRMA report), and many new products have reached patients in recent years, cancer that has metastasized remains very difficult to treat.  Metastasis occurs in as many as 40 percent of breast cancer cases.

Currently available platin-based drugs are powerful cancer therapies, yet their impact is often diminished by toxicity and resistance, even for newer drugs such as carboplatin and oxaliplatin.  By designing novel therapeutic agents based on an understanding of metabolic cell death pathways and targeting these drugs to mitochondria, PMX has identified effective new platins with lower toxicity.

As part of the collaboration, SRI researchers will perform preclinical research and development (R&D) studies on novel chemotherapeutics provided by PMX and its commercial development partner.  SRI will receive royalties on sales of specific PMX drugs and an equity stake in the company once R&D milestones are met.  PMX will seek additional funding and partnerships to advance its leads into clinical trials and to market.

"Having collaborated with Dr. Steliou on a number of innovative programs for more than a decade, I am pleased to announce this joint effort with PMX around new drugs that have the potential to increase the efficacy of platins while reducing their side effects and decreasing resistance," said Walter
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SOURCE SRI International
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