Navigation Links
SRI International Researchers Present Promising New Therapeutic for the Treatment of Multiple Myeloma
Date:5/11/2010

MENLO PARK, Calif., May 11 /PRNewswire/ -- SRI International, an independent nonprofit research and development organization, announced today that researchers have developed an anti-angiogenic molecule SR16388 that has demonstrated preclinical antitumor activity against multiple myeloma (MM). The new research was recently presented at the annual meeting of the American Association for Cancer Research (AACR), held in Washington, D.C.

Multiple myeloma is a cancer of the immune system that affects plasma cells in bone marrow. It is the second most common blood-based malignancy (after lymphoma), affecting approximately 20,000 new patients each year.

"More effective treatment options for multiple myeloma are urgently needed and the SRI cancer drug discovery team is actively working on developing next-generation agents that may extend the lives of patients and lead to a cure," said Lidia Sambucetti, Ph.D., senior director of SRI's Center for Cancer Research.

SR16388 has been shown to have excellent oral bioavailability and a favorable safety profile.  In studies, it has shown to potently inhibit angiogenesis in lung and prostate cancers. Based on in vitro and in vivo preclinical data, SRI researchers believe that SR16388 has promise as a new therapeutic for the treatment of multiple myeloma. In the new work presented at AACR, researchers demonstrated that SR16388 inhibits the growth of multiple myeloma cells and experimental tumors. This agent is different from current multiple myeloma therapies in that it works by blocking the ability of cancer cells to survive and grow in hypoxic (low oxygen level) microenvironments that are typical of this malignancy. In part, the drug does this by inhibiting the development of new blood vessels that supply oxygen and nutrients to multiplying cancer cells. SR16388 is currently in late-stage preclinical development, which will prepare the agent for entry into human clinical trials.

About SRI's Biosciences Division

SRI's Biosciences Division carries out basic research, drug discovery, and drug development, and provides contract services. SRI has all of the resources necessary to take R&D from idea to IND®—from initial discovery to the start of human clinical trials—and specializes in cancer, immunology and inflammation, infectious disease, and neuroscience. SRI's product pipeline has yielded marketed drugs, therapeutics currently in clinical trials, and additional programs in earlier stages. In its CRO business, SRI has helped government and other clients and partners advance well over 100 drugs into patient testing. SRI is also working to create the next generation of technologies in areas such as diagnostics, drug delivery, medical devices, and systems biology.

About SRI International

Silicon Valley-based SRI International is one of the world's leading independent research and technology development organizations. SRI, which was founded by Stanford University as Stanford Research Institute in 1946 and became independent in 1970, has been meeting the strategic needs of clients and partners for more than 60 years. Perhaps best known for its invention of the computer mouse and interactive computing, SRI has also been responsible for major advances in networking and communications, robotics, drug discovery and development, advanced materials, atmospheric research, education research, economic development, national security, and more. The nonprofit institute performs sponsored research and development for government agencies, businesses, and foundations. SRI also licenses its technologies, forms strategic alliances, and creates spin-off companies. In 2009, SRI's consolidated revenues, including its wholly owned for-profit subsidiary, Sarnoff Corporation, were approximately $470 million.


'/>"/>
SOURCE SRI International
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Medicomps Decipher Holter Monitor Provides Cardiac Reporting on the International Space Station
2. Novo Nordisk partners with international scientific community for Victoza(R) cardiovascular outcomes trial
3. Lexicon to Present at BIO International Convention
4. Phytomedics Inc. To Present at BIO 2010 International Convention
5. Systech International(R) Celebrates 25 Years of Innovating Packaging Technology Solutions
6. International Merchant Advisors to Develop Organic Science Branded Medical Marijuana Product Line
7. Winner Medical Participates in CMEF 2010, China International Medical Equipment Fair, in Shenzhen
8. International Merchant Advisors Completes All Stock Based Purchase of Medical Marijuana Company Organic Science, Inc.
9. Essilor Acquires FGX International, Becoming a Major Player in a New Fast-Growing Market
10. PricewaterhouseCoopers to Present First International Market Scorecard on Medical Technology Innovation at the 2010 International Medical Device Industry Compliance Congress
11. Bacterin International Introduces OsteoSelect(R) DBM Putty
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... 23, 2016 Capricor Therapeutics, ... a biotechnology company focused on the discovery, development ... patient enrollment in its ongoing randomized HOPE-Duchenne clinical ... 50% of its 24-patient target. Capricor expects the ... quarter of 2016, and to report top line ...
(Date:6/23/2016)... RIDGE, Ill. and INDIANAPOLIS ... of students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship ... The 2016 scholarship winners, announced today online at ... to let type 1 diabetes stand in the way ... Diabetes has supported the Foundation,s scholarship program since 2012, ...
(Date:6/23/2016)... , June 23, 2016 The vast majority ... outpatient dialysis facility.  Treatments are usually 3 times a ... per visit, including travel time, equipment preparation and wait ... but especially grueling for patients who are elderly and ... skilled nursing and rehabilitation centers for some duration of ...
Breaking Medicine Technology:
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced ... feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as a ... has released tools for healthy coping following a traumatic event. , Trauma sufferers tend ...
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
(Date:6/24/2016)... ... 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 ... by their peers for this recognition are considered among the top 2 percent of ... honors as members of this year’s Legal Elite Hall of Fame: Miami Shareholders ...
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
Breaking Medicine News(10 mins):