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SRI International Receives U.S. Patent for Needle-Free Transmucosal Drug Delivery System
Date:12/15/2009

stem is equally well suited for both systemic conditions that affect the whole body and localized conditions that affect specific parts of the body.

The mucous membrane of the nasal cavity is most frequently used for delivery of antigens and medications against localized infections. Because mucous membranes respond strongly to foreign matter and can offer a hospitable environment for pathogens and antigens, they are ideally suited for the introduction of vaccines, where both systemic and local immune responses are desired. Most pediatric vaccines are injections, which can be painful to children and difficult to administer safely in poorer regions of the world. SRI's needle-free technology can be used to safely deliver vaccines nasally, including those for pediatric use. The system can also be used to administer contraceptive formulations or to provide topical microbicides that protect against sexually transmitted diseases, such as HIV and genital herpes.

The novel bioadhesive drug delivery system was developed as part of an SRI project funded in part under a National Institutes of Health grant to develop a nasal formulation for anthrax antigens, suitable for mass-immunization in the event of a bioterrorism emergency. Other applications being developed include use of the drug delivery system to deliver therapeutics that protect against chemical warfare agents.

The project described was supported by grant number 1 R03 AI059234 from the National Institute of Allergy and Infectious Diseases, a division of the National Institutes of Health.

About SRI's Biosciences Division

SRI's Biosciences Division carries out basic research, drug discovery, and drug development, and provides contract services. SRI has all of the resources necessary to take R&D from Idea to IND®--from initial discovery to the start of human clinical trials--and specializes in cancer, immunology and inflammation, infectious dis
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