Navigation Links
SCH 530348 (TRA), a Novel Investigational Antiplatelet Agent, Shown to Inhibit Platelet Aggregation in PCI Patients
Date:11/7/2007

ent of atherothrombotic events in patients with acute coronary syndrome and in those with prior myocardial infarction or stroke, as well as in patients with existing peripheral arterial disease.

The U.S. Food and Drug Administration (FDA) had previously granted Fast Track designation to the compound. Fast Track designation allows FDA to expedite review of drugs and biologics for serious or life-threatening conditions which demonstrate the potential to address unmet medical needs.

Thrombosis may result in partial or complete blockage of arteries in the heart, brain or periphery. This process is the underlying mechanism of most acute vascular events, including acute coronary syndromes (ACS), such as myocardial infarction (MI), and ischemic stroke, which are the leading causes of death. Platelets are activated at the site of atherosclerotic plaque rupture in arteries and release substances that initiate aggregation and clot formation, and thrombin is the most potent activator of platelets. Drugs that block platelet activation by other mechanisms, such as the thromboxane- or ADP-mediated pathways, have shown reduction in such clinical events, but events continue to occur despite these therapies. There is, thus, a need for novel agents that specifically modify the actions of thrombin, the most potent activator of platelets.

TRA binds selectively to the thrombin receptor on platelets (PAR-1), and is therefore a member of a potentially new class of drugs called thrombin receptor antagonists.

Importantly, Schering-Plough's TRA is being investigated to determine whether it has the potential to provide clinical benefit through inhibition of this thrombin-mediated platelet activation without the liability of increased bleeding (when added to standard of care), a tendency associated with drugs that block thromboxane or ADP pathways. Specifically, this compound is being investigated as an oral antiplatelet agent for patients with established vascular dise
'/>"/>

SOURCE Schering-Plough Corporation
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Novel Technology Breaks Through Cancer Pain
2. Iomai Trial Shows 100 Percent Immune Response in Elderly Subjects Vaccinated With Novel Travelers Diarrhea Patch Vaccine
3. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
4. Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
5. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
6. The Lancet Publishes Major Phase 3 Study on Novel Oral Direct Thrombin Inhibitor
7. Study Results for Aclidinium Bromide, a Novel Anticholinergic, Presented at European Respiratory Society Annual Congress
8. Phase 2 Clinical Studies Initiated for a Novel Therapeutic Candidate Identified Through Pharmacopeia Collaboration
9. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
10. ECLIPSE Data on Effects of Otsukas Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients Hemodynamics and Urine Output Featured in Heart Failure Society of Americas Late Breaking Trials
11. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... , July 24, 2014  IRIDEX Corporation (NASDAQ: ... its second quarter 2014 financial results after the market ... conjunction with the release, the Company will host a ... p.m. Eastern Time on Thursday, July 31, ... and other business developments. Interested parties may ...
(Date:7/24/2014)... and MENLO PARK, Calif. , July ... DMPI) ("DelMar" "the company") announced today that the company,s board ... from December 31 to June 30. Accordingly, DelMar will file ... Jeffrey Bacha , president and CEO of ... important step in achieving our goal of obtaining a senior ...
(Date:7/24/2014)... 2014  Kinex Pharmaceuticals announced the receipt of an ... Ointment for the commencement of a Phase I clinical ... IND to be allowed by the US FDA in ... synthetic, orally active and highly selective inhibitor of Src ... induction of p53, G2/M arrest of proliferating cell populations ...
Breaking Medicine Technology:DelMar Pharmaceuticals Announces Change of Fiscal Year End and Provides Update on Glioblastoma Clinical Trial 2DelMar Pharmaceuticals Announces Change of Fiscal Year End and Provides Update on Glioblastoma Clinical Trial 3Kinex Pharmaceuticals Announces Allowance of the Investigational New Drug (IND) application for KX2-391 Ointment by the United States Food and Drug Administration (FDA) 2Kinex Pharmaceuticals Announces Allowance of the Investigational New Drug (IND) application for KX2-391 Ointment by the United States Food and Drug Administration (FDA) 3Kinex Pharmaceuticals Announces Allowance of the Investigational New Drug (IND) application for KX2-391 Ointment by the United States Food and Drug Administration (FDA) 4
... , , NEW YORK , Feb. 9 ... online, print and print-on-demand publication from LIVE STRONG .  The magazine ... resources and information about cancer prevention and treatment; and general articles ... survivor, I understand the worries and concerns other survivors face on ...
... SAN DIEGO , Feb. 9 Volcano Corporation ... precision intravascular therapy guidance tools designed to enhance the diagnosis ... that it has received 510(k) clearance from the U.S. Food ... digital IVUS catheter in the United States . This ...
Cached Medicine Technology:SPOT ON media and LIVESTRONG(R) Launch LIVESTRONG Quarterly 2SPOT ON media and LIVESTRONG(R) Launch LIVESTRONG Quarterly 3SPOT ON media and LIVESTRONG(R) Launch LIVESTRONG Quarterly 4Volcano Receives FDA Clearance to Market the Eagle Eye(R) Platinum Digital IVUS Catheter 2Volcano Receives FDA Clearance to Market the Eagle Eye(R) Platinum Digital IVUS Catheter 3Volcano Receives FDA Clearance to Market the Eagle Eye(R) Platinum Digital IVUS Catheter 4
(Date:7/24/2014)... The Traffic and Leads Training ... to help users generate traffic and leads has just ... excitement throughout the internet marketing community. The excitement surrounding ... Tiffany Hendricks prompting a comprehensive review of the course. ... internet marketing will tell you, it can be quite ...
(Date:7/24/2014)... Ticket Down is a reliable source ... at the Sports Authority Field on July 26th. For the ... has brought some of the best club teams from around the ... still being raved about weeks after its completion, fans – new ... of the biggest stars in the world compete. Some of these ...
(Date:7/24/2014)... The report, “Content Delivery Networks (CDN) ... various sub-segments with an in-depth analysis and forecasting ... restraints for this market with insights on trends, ... tables and 36 figures spread through 157 pages ... Market” at http://www.marketsandmarkets.com/Market-Reports/content-delivery-networks-cdn-market-657.html . , Early ...
(Date:7/24/2014)... New York, New York (PRWEB) July 24, 2014 ... of GranuFlo lawsuits ( http://www.injurybeacon.com/granuflo-dialysis/lawsuit/ ) in ... issued a qualified protective order for plaintiff medical ... and Accountability Act. According to the July 16th ... granted attorneys for Fresenius Medical Care ...
(Date:7/24/2014)... (PRWEB) July 24, 2014 In a July ... expert and founder of Lotus Blossom Consulting LLC , ... entitled Three Ways to Cut the High Cost of ... to minimize costs is to maximize your chance of success ... on choosing a clinic. , “I am always happy ...
Breaking Medicine News(10 mins):Health News:Traffic And Leads Training Academy - Review Examining Jeff Johnson’s New IM Course Released 2Health News:Manchester United vs. AS Roma Tickets Denver Sports Authority Field at Mile High: Ticket Down Cuts Ticket Prices for Guinness International Champions Cup Match 2Health News:Manchester United vs. AS Roma Tickets Denver Sports Authority Field at Mile High: Ticket Down Cuts Ticket Prices for Guinness International Champions Cup Match 3Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 2Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 3Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 4Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 2Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 3Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 4Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 2Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 3
... Elsevier, a world-leading publisher of medical information products and ... Medical Press (PUMP) it has donated over 5,000 books ... The initiative is supported by the Development Centre for ... book donation is in line with the spirit of ...
... Rainbow Kitchen celebrates its 25th year of service to the ... period of economic hardship means that the help the organization ... , The 25th anniversary will be marked with a ... Scott Lammie - UPMC Health Plan,s Chief Financial Officer and ...
... ... Electronic Payment Exchange (EPX), a leading merchant acquirer ... data field encryption best practices provides welcome leadership to merchants, technology ... of data breach. EPX is the first payment processor to offer ...
... ... direct-to-consumer provider of premium dietary supplements, announces the release of their Mediterranean Diet ... ... a leading direct-to-consumer provider of premium dietary supplements, announces the release of their ...
... ... therapy affect integration into society,• Marriage is predicted by height, physical functioning, cognitive outcomes ... Philadelphia ... effects of cancer treatment on physical health, and results of a new study suggest ...
... LAKE CITY, Oct. 7 Utah residents will have access ... tomorrow. The Utah Drug Card is a free discount prescription ... to 75% on prescription drugs at retail pharmacies. All Utah ... printing a card on the program,s website www.utahdrugcard.com ...
Cached Medicine News:Health News:Elsevier's Health Sciences Division and Peking University Medical Press cooperate on book donation 2Health News:Rainbow Kitchen Celebrates 25th Anniversary in Pittsburgh 2Health News:Electronic Payment Exchange Welcomes New Visa Best Practices for Data Field Encryption 2Health News:Electronic Payment Exchange Welcomes New Visa Best Practices for Data Field Encryption 3Health News:Purity Products Releases Their Brand New Mediterranean Diet Resveratrol Formula 2Health News:Survivors of Childhood Cancer Less Likely to Marry 2Health News:Survivors of Childhood Cancer Less Likely to Marry 3Health News:Survivors of Childhood Cancer Less Likely to Marry 4
... word "laboratory," it brings to mind images of test ... items. With the introduction of the Brady Code Reader ... to the list of critical lab tools. Brady Corporation ... for the lab with the introduction of the CR2. ...
Reads single TrakMates tubes instantly, and drops decoded tube number instantly into any Windows application. System includes reader and Windows based software....
... top with powder-coated steel legs. ... Available in hundreds of sizes ... drawers, light fixtures and ionizing ... in custom building to meet ...
Perforated or Rod Top, Free Standing or Wall Mounted, Storage Cubby Optional, Polypropylene Construction...
Medicine Products: