Navigation Links
SCH 530348 (TRA), a Novel Investigational Antiplatelet Agent, Shown to Inhibit Platelet Aggregation in PCI Patients
Date:11/7/2007

cular death, MI or stroke. Patients will be followed for a minimum of one year. This Phase III trial is being conducted by the Thrombolysis in Myocardial Infarction (TIMI) Study Group.

The Phase III Thrombin Receptor Antagonist Clinical Event Reduction in acute coronary syndrome (TRA-CER) trial is a multinational, randomized, double-blind, placebo-controlled study in approximately 10,000 patients with non-ST-segment elevation acute coronary syndrome. Patients will be randomized to either placebo plus standard medical care (including aspirin or clopidogrel) or to TRA plus standard medical care. The Phase III TRA-CER trial will use the oral 40 mg loading dose and the 2.5 mg maintenance dose. In the Phase II TRA-PCI trial, this dose was not statistically different from placebo in the combination of TIMI Major and Minor bleeding, and although not statistically significant, resulted in the greatest reduction in major adverse cardiac events, predominately periprocedural myocardial infarctions.

The primary endpoint of the Phase III TRA-CER trial is the composite of cardiovascular death, MI, rehospitalization for ACS, urgent coronary revascularization or stroke. The key secondary endpoint is the composite of cardiovascular death, MI or stroke. Patients will be followed for a minimum of one year. This Phase III trial is being conducted by the Duke Clinical Research Institute, Durham, NC.

These Phase III trials follow the results of two Japanese Phase II trials in ACS patients and in patients with previous ischemic events that further documented the lack of incremental bleeding with the use of TRA plus standard of care, and, for the first time, reported a statistically significant reduction in cardiovascular events, specifically periprocedural myocardial infarction (MI) in the ACS patients undergoing PCI.

About the Thrombin Receptor Antagonist

The investigational antiplatelet TRA is being developed by Schering-Plough for the prevention and treatm
'/>"/>

SOURCE Schering-Plough Corporation
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Novel Technology Breaks Through Cancer Pain
2. Iomai Trial Shows 100 Percent Immune Response in Elderly Subjects Vaccinated With Novel Travelers Diarrhea Patch Vaccine
3. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
4. Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
5. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
6. The Lancet Publishes Major Phase 3 Study on Novel Oral Direct Thrombin Inhibitor
7. Study Results for Aclidinium Bromide, a Novel Anticholinergic, Presented at European Respiratory Society Annual Congress
8. Phase 2 Clinical Studies Initiated for a Novel Therapeutic Candidate Identified Through Pharmacopeia Collaboration
9. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
10. ECLIPSE Data on Effects of Otsukas Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients Hemodynamics and Urine Output Featured in Heart Failure Society of Americas Late Breaking Trials
11. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... AUSTIN, Texas , March 31, 2015 MedSpring Urgent ... in the Dallas/Fort-Worth area of Upper Greenville. ... company,s second Dallas location. Knox ... been well received by the surrounding community since opening last fall. ... to open in the Keller and Las ...
(Date:3/31/2015)... Columbia , March 31, 2015  InMed ... clinical stage biopharmaceutical company that specializes in developing ... appointment of Paul C. Anderson , Ph.D., ... a pharma industry veteran who brings significant drug ... Dr. Anderson is a synthetic organic chemist by ...
(Date:3/31/2015)... 31, 2015  Galmed Pharmaceuticals Ltd. (Nasdaq: ... on the development and commercialization of a once-daily, ... and cholesterol gallstones, today announced financial results for ... Fourth Quarter 2014 Highlights: , Hosted ... address by Professor Rohit Loomba, MD, MHSc., who ...
Breaking Medicine Technology:MedSpring Urgent Care Opens New Upper Greenville Location in Dallas 2InMed Pharmaceuticals Strengthens Scientific Advisory Board 2InMed Pharmaceuticals Strengthens Scientific Advisory Board 3InMed Pharmaceuticals Strengthens Scientific Advisory Board 4Galmed Pharmaceuticals Reports Full Year 2014 Financial Results and Provides Business Update 2Galmed Pharmaceuticals Reports Full Year 2014 Financial Results and Provides Business Update 3Galmed Pharmaceuticals Reports Full Year 2014 Financial Results and Provides Business Update 4Galmed Pharmaceuticals Reports Full Year 2014 Financial Results and Provides Business Update 5Galmed Pharmaceuticals Reports Full Year 2014 Financial Results and Provides Business Update 6Galmed Pharmaceuticals Reports Full Year 2014 Financial Results and Provides Business Update 7Galmed Pharmaceuticals Reports Full Year 2014 Financial Results and Provides Business Update 8
... 11, 2011 Panasonic Healthcare Group and United Cardio ... with Cenegenics Medical Institute to implement some of the ... age management. Panasonic,s CardioHealth® Station continues to get the ... the best ways to reduce long-term healthcare costs is ...
... YORK, Nov. 11, 2011 Keryx Biopharmaceuticals, Inc. (Nasdaq: ... Chief Executive Officer, will be presenting at the Lazard Capital ... Hotel in New York City. Mr. Bentsur,s presentation is scheduled ... a.m. ET. A live audio webcast of Mr. ...
Cached Medicine Technology:Panasonic Unveils Relationship with Cenegenics Medical Institute Featuring CardioHealth Station 2Panasonic Unveils Relationship with Cenegenics Medical Institute Featuring CardioHealth Station 3Panasonic Unveils Relationship with Cenegenics Medical Institute Featuring CardioHealth Station 4Keryx Biopharmaceuticals to Present at Lazard Capital Markets 8th Annual Healthcare Conference 2
(Date:3/31/2015)... Clara, CA (PRWEB) March 31, 2015 ... (IPD), has introduced a wire-bondable silicon ESD diode chip targeted ... of bare-die diode offerings, these Zeners are ideal for protecting ... ESD2117 diode can handle pulses of up to ... level 4 of the IEC 61000-4-2 standard. These diodes ...
(Date:3/31/2015)... 31, 2015 Clinovo, a leading ... Membership Program , the premiere voice of Northern ... life science companies. , BayBio brings together ... most innovative and productive life science cluster, helping ... of humanity’s most pressing challenges. , “We ...
(Date:3/31/2015)... At Summit Breast Care, their passion is to ... and caring manner. , Summit Breast Care has achieved national ... breast cancer. They treat thousands of patients annually, not ... world. Their doctors continue to be recognized as ‘Top ... Summit Breast Care were planted in the mind and spirit ...
(Date:3/31/2015)... Beckman Coulter is sponsoring a new ... Particulate Matter in Therapeutic Protein Injections”,” an educational session that ... counting particles in liquids, with a focus on the challenges ... to attend and will be broadcast live April 8, 2015 ... test for protein-based materials, known as USP 787 , ...
(Date:3/31/2015)... BESLER Consulting today announced the ... of an Independent Cost Report Review.” , The ... role in the determination of Medicare reimbursement to ... and review, this report can assist management in ... This white paper discusses:,     The ...
Breaking Medicine News(10 mins):Health News:OnChip Introduces Low Voltage Diodes for High-Brightness LED Protection 2Health News:Clinovo Joins BayBio Membership Program, The Leading Life Science Association in Northern California 2Health News:Summit Breast Care is Celebrating Four Years as "NJ Top Docs" 2Health News:Beckman Coulter Webinar Series Presents Insight into New Demands in Counting Particles in Liquids 2Health News:Beckman Coulter Webinar Series Presents Insight into New Demands in Counting Particles in Liquids 3
... India's leading vaccine manufacturer Serum Institute of India has manufactured ... vaccines // . ,The vaccine is called Td-Vac ... adolescents and adults. The new vaccine will replace the existing ... ,Td-Vac is priced at Rs 7.50 whereas the TT ...
... has given health the status of industry. The positive ... all facilities provided under the industrial policy. Nursing homes ... support. ,The government move is expected to ... sector in state, where half the population lives below ...
... Israeli scientists have developed a test that can detect the ... led by Arieh Yaari of Soroka University Medical Centre // ... patients, people without kidney functions whose blood must be passed ... portal SciDev Net. ,Such patients have a high incidence ...
... soaps or serials give a false picture about coma survival ... data of sufferings felt // by coma patients and ... television soaps is not true as the study show that ... for instance, compared with 50% upwards in real life. ...
... fear that if the deadly bird flu hits the country then ... // to the H5N1 virus. The bird flu or the avian ... appeared in parts of Europe including Ukraine. ,Around ... the virus. However, experts fear that if it mutates to a ...
... Researchers from the University of Pennsylvania have obtained valuable ... using a technique // called functional magnetic resonance imaging. ... the brain that are active during an event are ... ,"This study shows that, as you search ...
Cached Medicine News:Health News:Magnetic Resonance Imaging Can Now Be Used For Mind Reading 2
MediNotes e is an EMR design which utilizes a "tab concept for navigation. MediNotes e can display multiple patients, encounter notes, workflow items, patient flow, messages, alerts, and more, all in...
... Pro Software developed a touchscreen EHR and ... While a user can choose to use ... to maintain eye contact while recording encounter ... Pro EHR also runs on a pen ...
... Anasazi Clinicians HomePage is a comprehensive on-line ... helps you by reducing your time and ... to concentrate on the clients quality of ... completes a chart audit and shows you ...
... The GE RecordsTFC System ... Registration and other patient/resident record ... approach. It supports multiple facilities ... outpatient and ambulatory clinics, community ...
Medicine Products: