Navigation Links
SCH 530348 (TRA), a Novel Investigational Antiplatelet Agent, Shown to Inhibit Platelet Aggregation in PCI Patients
Date:11/7/2007

in New Orleans.

Study Results

IPA responses to the thrombin receptor agonist peptide (TRAP), adenosine diphosphate (ADP), collagen and arachidonic acid (AA) were measured using light transmission aggregometry at baseline and 30, 60, 90 and 120 minutes following a loading dose (10, 20 or 40 mg vs. placebo) and after a maintenance dose (0.5, 1.0 or 2.5 mg/day) at 30 and 60 days. PK was assessed at 30 and 60 minutes and 2 hours after loading dose administration.

TRA was active in inhibiting 15.M TRAP-induced platelet aggregation with onset of inhibition directly related to dose. The 40 mg loading dose resulted in 96.3 percent of patients achieving greater than 80 percent TRAP-induced platelet aggregation inhibition within two hours, compared with 52.9 percent of patients for the 20 mg loading dose and 42.9 percent of patients for the 10 mg loading dose.

The sub-study demonstrated that for the 1.0 mg and 2.5 mg maintenance dose groups, all patients exhibited greater than 80 percent IPA at both 30 and 60 days. Placebo-treated patients had, on average, less than or equal to 10 percent IPA to TRAP.

TRA had no significant effects on ADP, collagen or AA-induced platelet aggregation compared with placebo.

About the Phase III Trials

The Phase III Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2P-TIMI 50) trial is a multinational, randomized, double-blind, placebo-controlled study in approximately 19,500 patients with prior MI or stroke, as well as patients with existing peripheral arterial disease. Patients will be randomized to either placebo plus standard medical care (including aspirin and clopidogrel) or to TRA once daily plus standard medical care. This Phase III trial will use the 2.5 mg maintenance dose. The primary endpoint of the trial is the composite of cardiovascular death, MI, urgent coronary revascularization or stroke. The key secondary endpoint is the composite of cardiovas
'/>"/>

SOURCE Schering-Plough Corporation
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Novel Technology Breaks Through Cancer Pain
2. Iomai Trial Shows 100 Percent Immune Response in Elderly Subjects Vaccinated With Novel Travelers Diarrhea Patch Vaccine
3. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
4. Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
5. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
6. The Lancet Publishes Major Phase 3 Study on Novel Oral Direct Thrombin Inhibitor
7. Study Results for Aclidinium Bromide, a Novel Anticholinergic, Presented at European Respiratory Society Annual Congress
8. Phase 2 Clinical Studies Initiated for a Novel Therapeutic Candidate Identified Through Pharmacopeia Collaboration
9. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
10. ECLIPSE Data on Effects of Otsukas Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients Hemodynamics and Urine Output Featured in Heart Failure Society of Americas Late Breaking Trials
11. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2015)... , Mar. 26, 2015 Research and ... announced the addition of the "Urological ... report to their offering. This ... Catheters in Thousand Units and US$ Thousands ... (Hemodialysis Catheters, & Peritoneal Catheters), and Urinary ...
(Date:3/30/2015)... , March 30, 2015  Caris Life Sciences® today ... targeting specific pathways may have potentially significant benefit in ... study results were highlighted today in an oral presentation ... Oncology (SGO) 2015 Annual Meeting on Women,s Cancer in ... study is one of four presented at the annual ...
(Date:3/30/2015)... March 30, 2015  Cochlear Corporation Vice President ... leave Cochlear to join Valencia Technologies ( www.valenciatechnologies.com ... Jeff Greiner , who is the CEO of ... Development and will be responsible for generating enthusiasm ... Valencia,s coin-sized neuromodulation device in the ...
Breaking Medicine Technology:Urological Catheters - Global Strategic Business Report 2015-2020: Burgeoning Ageing Populace to Propel Catheter Usage 2Urological Catheters - Global Strategic Business Report 2015-2020: Burgeoning Ageing Populace to Propel Catheter Usage 3Urological Catheters - Global Strategic Business Report 2015-2020: Burgeoning Ageing Populace to Propel Catheter Usage 4Urological Catheters - Global Strategic Business Report 2015-2020: Burgeoning Ageing Populace to Propel Catheter Usage 5Urological Catheters - Global Strategic Business Report 2015-2020: Burgeoning Ageing Populace to Propel Catheter Usage 6Urological Catheters - Global Strategic Business Report 2015-2020: Burgeoning Ageing Populace to Propel Catheter Usage 7Caris Life Sciences' Multiplatform Tumor Profiling Enhances Understanding of Molecular Drivers and Treatment Selection in Uterine Carcinomas 2Caris Life Sciences' Multiplatform Tumor Profiling Enhances Understanding of Molecular Drivers and Treatment Selection in Uterine Carcinomas 3Caris Life Sciences' Multiplatform Tumor Profiling Enhances Understanding of Molecular Drivers and Treatment Selection in Uterine Carcinomas 4Cochlear VP of U.S. Sales Jerry Schloffman Accepts Chief of Market Development Position at Valencia Technologies 2
... Aug. 17 Cardica, Inc. (Nasdaq: CRDC ) ... year ended June 30, 2010. Cardica,s management will host a ... financial results and provide an update on the company,s business. ... efforts on the Microcutter family of products and we have ...
... 17 BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ... Inc. (ZyStor), a privately-held biotechnology company developing enzyme replacement ...  ZyStor,s lead product candidate is ZC-701, a novel fusion ... in development for Pompe disease. Under the ...
Cached Medicine Technology:Cardica Announces Fiscal 2010 Fourth Quarter and Year End Financial Results 2Cardica Announces Fiscal 2010 Fourth Quarter and Year End Financial Results 3Cardica Announces Fiscal 2010 Fourth Quarter and Year End Financial Results 4Cardica Announces Fiscal 2010 Fourth Quarter and Year End Financial Results 5Cardica Announces Fiscal 2010 Fourth Quarter and Year End Financial Results 6BioMarin Acquires ZyStor Therapeutics, Inc. 2BioMarin Acquires ZyStor Therapeutics, Inc. 3BioMarin Acquires ZyStor Therapeutics, Inc. 4BioMarin Acquires ZyStor Therapeutics, Inc. 5
(Date:3/31/2015)... Colo. (PRWEB) March 31, 2015 A new ... recruiters in the U.S. rank employee turnover as their greatest ... employees is only half the battle – once you have ... of Health eCareers’ new trends in healthcare recruiting blog ... Recruiting Trends Survey. , Turnover in hospitals has high numbers ...
(Date:3/31/2015)... Buffalo, NY (PRWEB) March 31, 2015 ... been recognized by peers across the country for distinguished ... profession. The New York State Athletic Trainers’ Association ... extend congratulations to these NYS athletic trainers - especially ... (NATM)! The Ed Block Courage Award for ...
(Date:3/30/2015)... Dundee, Fl (PRWEB) March 31, 2015 ... Ali Hamtaee has recently opened his AlignLife clinic. As ... integrated offering of chiropractic, rehabilitation and nutritional consulting for ... behind AlignLife is based on the expertise and compassion ... must pass a rigorous evaluation process and an extensive ...
(Date:3/30/2015)... AZ (PRWEB) March 31, 2015 Phoenix ... Phoenix, AZ, announces the launch of the PSP Institute. ... individually relevant learning and development with a direct connection ... extension of the original work of the Phoenix Strategic ... of the assessment platform is in an organization’s ability ...
(Date:3/30/2015)... City, NY (PRWEB) March 31, 2015 ... Owner / Operator for Diamond Pharmacy Services, ... Ms. Mitchell is recognized with this prestigious distinction ... networking organization of professional women in the country, ... Association of Professional Women is a powerfully vibrant ...
Breaking Medicine News(10 mins):Health News:New Survey Finds Staff Turnover Top Concern for Healthcare Recruiters in 2015 2Health News:New Survey Finds Staff Turnover Top Concern for Healthcare Recruiters in 2015 3Health News:New Survey Finds Staff Turnover Top Concern for Healthcare Recruiters in 2015 4Health News:NYS Athletic Trainers' Association Congratulates Buffalo Bills Athletic Training Staff for National Award 2Health News:NYS Athletic Trainers' Association Congratulates Buffalo Bills Athletic Training Staff for National Award 3Health News:Phoenix Strategic Performance Launches Human Capital Development Institute 2Health News:Phoenix Strategic Performance Launches Human Capital Development Institute 3Health News:National Association of Professional Women Announces Tamara Mitchell, Owner / Operator of Diamond Pharmacy Services, a 2015 Professional Woman of the Year 2
... Board to Access State Funding, WOODLAND, Calif., Sept. ... Supervisors on Tuesday to increase funding for In-Home,Supportive Services, ... low-income seniors and people with disabilities. Workers represented ... the county for a new contract to cover the,1,300 ...
... have stood stubbornly behind President Bush on,issue after issue ... his threat,to veto health care for low-income children. America,s ... Romney and Fred Thompson veto,the children,s health care bill ... came up for discussion during an August debate in ...
... ... Area; 32% of HIV Cases in ... Are Female, ST. PETERSBURG, Fla., Sept. 25 /PRNewwire-USNewswire/ -- The following,was released today by the AIDS ... Thursday, September 27, 20077:00pm, Where: Poynter Park ...
... future, quick diagnoses should mean better treatment, experts say ... pattern of brain activity could be a sign of ... that as new treatments for Alzheimer,s become available, spotting ... team at Duke University Medical Center in Durham, N.C., ...
... less likely to develop diabetes, study says, , , TUESDAY, Sept. ... type 1 diabetes might be able to prevent the disease ... study suggests. , Reporting in the Sept. 26 issue of ... from the University of Colorado found that high-risk children with ...
... , , TUESDAY, Sept. 25 (HealthDay News) -- People newly ... normal incidence of colorectal tumors and cancers, a study ... and the heart disease "probably develop through the mechanism ... the University of Hong Kong that,s published in the ...
Cached Medicine News:Health News:Homecare Workers to Supervisors: Preserve Care of our Most Vulnerable 2Health News:Voters Deserve to Know: Would Giuliani, McCain, Romney and Thompson Stand with Bush and Veto Children's Health Care? 2Health News:Voters Deserve to Know: Would Giuliani, McCain, Romney and Thompson Stand with Bush and Veto Children's Health Care? 3Health News:Voters Deserve to Know: Would Giuliani, McCain, Romney and Thompson Stand with Bush and Veto Children's Health Care? 4Health News:St. Petersburg: Candlelight Vigil to Raise Awareness of Florida HIV/AIDS Crisis, Honor Lives Lost 2Health News:St. Petersburg: Candlelight Vigil to Raise Awareness of Florida HIV/AIDS Crisis, Honor Lives Lost 3Health News:Brain Activity Might Point to Early Alzheimer's 2Health News:Omega-3s Guard Against Type 1 Diabetes 2Health News:Omega-3s Guard Against Type 1 Diabetes 3Health News:Study Links Coronary Disease, Colon Cancer 2
... Injectable was designed to provide the surgeon with ... of surgical complications during cataract and retinal surgery. ... small and medium sized pupils which allows expansion ... iris sphincter during surgery, and allows the pupil ...
... Laminar Flow Unit is a flexible, total solution. ... to operating theaters since 1983. A major part ... and extensive experience from all the different areas ... product , ,Kojair Tech Oy is a comprehensive ...
Provides stable positioning of the knee during surgery....
BRAT 2 Autologous Blood Recovery System gives performance, speed, versatility, and quality processing. , ,The BRAT 2 is now available with on-board Vacuum, programmability, plasma sequestration, Data...
Medicine Products: