Navigation Links
SCH 530348 (TRA), a Novel Investigational Antiplatelet Agent, Shown to Inhibit Platelet Aggregation in PCI Patients
Date:11/7/2007

romising therapeutic option for patients with unstable angina and non-ST elevation MI undergoing PCI ," said Rick Veltri, M.D., Group Vice President of Global Clinical Research, Cardiovascular and Metabolic Disease, Schering- Plough Research Institute. "With our global Phase III clinical development program underway, we are continuing to evaluate the potential for TRA as a novel agent in reducing the incidence of cardiovascular events with no incremental bleeding when added to standard of care in the treatment of patients with acute coronary syndromes or established vascular disease," added Veltri.

The results were presented today at the American Heart Association Scientific Sessions in Orlando, FL, in a session titled "Thrombin Receptor Antagonist Is a Selective, Potent Inhibitor of PAR-1 Activity With Predictable Pharmacokinetics."

About TRA-PCI

The Phase II TRA-PCI Trial was a multinational, randomized, double-blind, placebo-controlled dose-ranging trial assessing oral loading doses and maintenance doses of TRA. The trial enrolled 1,030 patients randomized to one of three oral loading doses of TRA (10 mg, 20 mg, 40 mg) plus standard of care (clopidogrel + aspirin) or placebo plus standard of care in a 3:1 ratio of active drug to placebo. Patients who received a TRA-loading dose and subsequently underwent PCI (n=573) were randomized to one of three oral daily maintenance doses of TRA (0.5 mg, 1.0 mg, 2.5 mg). Patients who received placebo were randomized to receive standard of care alone. The total duration of treatment was 60 days. Patients were followed for an additional 60 days post-treatment.

A secondary endpoint in a sub-study within the primary evaluable patient cohort was inhibition of platelet aggregation (IPA) induced by appropriate agonists relative to baseline.

TRA-PCI results were first presented at a late-breaking clinical trial session at the March 2007 Scientific Sessions of the American College of Cardiology/i2 Summit
'/>"/>

SOURCE Schering-Plough Corporation
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Novel Technology Breaks Through Cancer Pain
2. Iomai Trial Shows 100 Percent Immune Response in Elderly Subjects Vaccinated With Novel Travelers Diarrhea Patch Vaccine
3. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
4. Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
5. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
6. The Lancet Publishes Major Phase 3 Study on Novel Oral Direct Thrombin Inhibitor
7. Study Results for Aclidinium Bromide, a Novel Anticholinergic, Presented at European Respiratory Society Annual Congress
8. Phase 2 Clinical Studies Initiated for a Novel Therapeutic Candidate Identified Through Pharmacopeia Collaboration
9. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
10. ECLIPSE Data on Effects of Otsukas Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients Hemodynamics and Urine Output Featured in Heart Failure Society of Americas Late Breaking Trials
11. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... -- AMETEK, Inc. (NYSE: AME ) today announced ... Vice President and General Manager, Engineered Medical Components, within ... "I am pleased that Kurt has joined AMETEK. ... especially in the medical device industry, and we expect ... and success of our medical components businesses," commented ...
(Date:7/25/2014)... 2014 Leading events organizer UBM Live ... the seventh year to São Paulo, Brazil ... 2014. The event will co-locate with Food Ingredients South America ... meeting point for the pharmaceutical industry.      (Logo: ... pharmaceutical sales are now exploring the South America ...
(Date:7/25/2014)... , July 25, 2014  Arena Pharmaceuticals, Inc. ... provide a corporate update and report second quarter 2014 ... on Friday, August 1, 2014. That same day, Arena ... a.m. Eastern Time (5:30 a.m. Pacific Time). ... 877.643.7155 for domestic callers and 914.495.8552 for international callers. ...
Breaking Medicine Technology:AMETEK Names Kurtis L. Goos, Vice President & General Manager, Engineered Medical Components 2CPhI South America 2014 Launches with Generics Showing Huge Growth 2CPhI South America 2014 Launches with Generics Showing Huge Growth 3CPhI South America 2014 Launches with Generics Showing Huge Growth 4Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Friday, August 1 2Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Friday, August 1 3
... Jan. 19, 2011 On February 1, 2011, the ... Center for Biomedical Innovation, and Engineering Systems Division will ... Systems Thinking from Discovery to Delivery ... day-long event, sponsored by Merrimack Pharmaceuticals, will be a ...
... RFID Journal features MEPS Real Time,s ... live or die depending on the correct medications being ... tracking of a drug,s expiration dates, information about the ... in REAL TIME, would assist in preventing errors. ...
Cached Medicine Technology:Michael Porter, Janet Woodcock, Peter Senge Among Speakers at Inaugural Innovation in Healthcare Symposium 2Michael Porter, Janet Woodcock, Peter Senge Among Speakers at Inaugural Innovation in Healthcare Symposium 3Michael Porter, Janet Woodcock, Peter Senge Among Speakers at Inaugural Innovation in Healthcare Symposium 4Michael Porter, Janet Woodcock, Peter Senge Among Speakers at Inaugural Innovation in Healthcare Symposium 5Michael Porter, Janet Woodcock, Peter Senge Among Speakers at Inaugural Innovation in Healthcare Symposium 6Michael Porter, Janet Woodcock, Peter Senge Among Speakers at Inaugural Innovation in Healthcare Symposium 7Michael Porter, Janet Woodcock, Peter Senge Among Speakers at Inaugural Innovation in Healthcare Symposium 8MEPS Real Time's New RFID Drug Management System Provides Critical Error Solution for California Hospital 2
(Date:7/25/2014)... The European liquid chromatography reagents report ... analysis and forecast of revenue. The liquid chromatography reagents ... in 2013, and is estimated to grow to around ... %, from 2013 to 2018. , Browse through the ... get an idea of the in-depth analysis provided. This ...
(Date:7/25/2014)... Researchers at Dartmouth-Hitchcock Norris Cotton Cancer Center are exploring ... recognizes and attacks invading cancer cells. Tumors protect themselves ... as normal, even while cancer cells are dividing and ... review article published this week in WIREs Nanomedicine ... ability to fight tumors. Nanoparticles are too small ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 The American ... new volunteer network “ABTA CommYOUnity™” during its annual patient ... pivotal time for the brain tumor community as we ... patient and caregiver support services and funding brain tumor ... are passionate about brain tumor awareness and getting our ...
(Date:7/25/2014)... 2014 The North America Artificial lift market ... America with analysis and forecast of revenue. The artificial lift ... $4.7 billion in 2013 to around $7 billion by 2018, ... , Browse through the TOC of North America artificial lift ... This also provides a glimpse of the segmentation in North ...
(Date:7/25/2014)... July 25, 2014 Agoura Hills dentist ... on Zoom Whitening. Zoom Whitening is one of the most ... through a dental professional. This light-assisted treatment uses a prescription-strength ... of the tooth to break up stains that are in ... coffee, tea, wine, soft drink and tobacco stains. , ...
Breaking Medicine News(10 mins):Health News:European Liquid Chromatography Reagents Market is Expected to Reach $1581.8 Million in 2018 - New Report by MicroMarket Monitor 2Health News:European Liquid Chromatography Reagents Market is Expected to Reach $1581.8 Million in 2018 - New Report by MicroMarket Monitor 3Health News:European Liquid Chromatography Reagents Market is Expected to Reach $1581.8 Million in 2018 - New Report by MicroMarket Monitor 4Health News:Scientists test nanoparticle 'alarm clock' to awaken immune systems put to sleep by cancer 2Health News:American Brain Tumor Association Unveils Brand Identity for Newly Launched Volunteer Network 2Health News:American Brain Tumor Association Unveils Brand Identity for Newly Launched Volunteer Network 3Health News:North America Artificial Lift Services Market is Expected to Reach $7 Billion in 2018 - New Report by MicroMarket Monitor 2Health News:North America Artificial Lift Services Market is Expected to Reach $7 Billion in 2018 - New Report by MicroMarket Monitor 3Health News:North America Artificial Lift Services Market is Expected to Reach $7 Billion in 2018 - New Report by MicroMarket Monitor 4Health News:Agoura Hills Dentist, Dr. Amir Choroomi, is Now Offering a Promotion on Zoom Whitening 2
... air pollution due to combustion has been proved to cause ... The research was done by Columbia Center for Children’s Environmental ... Columbia University, US. ,The researchers had observed the ... aromatic hydrocarbons (PAH) that can penetrate placenta to affect the ...
... Researchers have found a herb used in traditional Indian ... and insulin levels // in a manner similar to ... a herb called salacia oblonga, which is native to ... to intestinal enzymes that break down carbohydrates in the ...
... can learn certain words. To investigate whether children under age 1 ... another, researchers worked with parents of 52 children who were 9 ... set of 48 picture cards that depicted common objects such as ... The games were performed four times a week for up to ...
... use of the accepted drug Adderall XR for Attention-Deficit ... adverse reports. FDA, the US counterpart of Health Canada ... a press release has asked the parents of children ... to stop the medication for their children. ,Adderall ...
... than intravenous fluids for children who are dehydrated say ... rehydration therapy is recommended for children with mild to ... pediatric emergency medicine physicians do not use this therapy ... injecting the fluid directly into a vein. ,In ...
... Chennai today. The theme for the congress is Prevention of ... will attend the event from 38 countries across the world. ... once in every three years, since the time of its ... of the city is hosting this year’s three-day event ...
Cached Medicine News:
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: