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SCH 530348 (TRA), a Novel Investigational Antiplatelet Agent, Shown to Inhibit Platelet Aggregation in PCI Patients
Date:11/7/2007

Inhibition Was Sustained and Dose-Dependent in Sub-Analysis of Phase II

TRA- PCI Trial

ORLANDO, Fla., Nov. 7 /PRNewswire-FirstCall/ -- SCH 530348 (TRA), the novel investigational antiplatelet agent in development by Schering-Plough Corporation (NYSE: SGP), was shown to be a potent inhibitor of platelet aggregation in a sub-analysis of the Thrombin Receptor Antagonist - Percutaneous Coronary Intervention (TRA-PCI) trial presented today at the American Heart Association Scientific Sessions.

The pharmacokinetic and pharmacodynamic analysis, conducted by the University of Tennessee Health Science Center, Memphis, showed that SCH 530348 (TRA), a potent thrombin receptor antagonist, demonstrated sustained, dose- dependent, specific agonist-induced inhibition of platelet aggregation in blood samples from patients undergoing non-urgent percutaneous coronary intervention (PCI).

"The inhibition of platelet aggregation plays a critical role in reducing the formation of deleterious blood clots in patients undergoing PCI," said Lisa K. Jennings, Ph.D., FAHA, Professor, Department of Medicine; Director, Vascular Biology Center of Excellence, University of Tennessee Health Science Center, Memphis, TN; and lead author. "TRA's potentially unique mechanism of action inhibits platelet aggregation through a different pathway from other antiplatelet agents currently available," added Jennings.

"Despite recent advances in cardiovascular care, current levels of morbidity and mortality make it clear that an unmet medical need exists for patients with acute coronary syndromes and those at risk of atherothrombosis. We believe these results add to the evidence indicating that TRA may be a p
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SOURCE Schering-Plough Corporation
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