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SARS Vaccine Achieves Neutralizing Responses in First U.S. Human Trial
Date:12/9/2008

id Vijay Samant, Vical's President and Chief Executive Officer. "With the data from this successful Phase I trial and control of the IND, we are prepared to advance this vaccine quickly in the event of another outbreak. In the meantime, we can look to the model established with this program in addressing other emerging infectious diseases."

Side effects in the Phase I trial were typically mild, and no serious adverse events were reported. SARS-specific neutralizing antibody responses were detected in 8 of 10 subjects. SARS-specific CD4+ T-cell responses were detected in all 10 subjects, and CD8+ T-cell responses were detected in 2 of 10 subjects. Neutralizing antibody responses are important in preventing infection. CD4+ T cells help direct the appropriate immune resources against specific pathogens. CD8+ T cells find and kill infected cells and are important in clearing virus after infection.

About SARS

Following the initial cases of SARS, identified in the Guangdong Province of China in late 2002, the disease spread rapidly through the summer of 2003 and reached epidemic status, affecting more than 8,000 and killed more than 900 people in 25 countries before it was contained. SARS affects the respiratory system and gastrointestinal tract as well as other internal organs, with particular risk to the elderly and immunocompromised. Healthy adults may become infected and spread the disease without exhibiting any symptoms.

About DNA Vaccines

DNA vaccines may offer both technical and economic advantages compared with conventional vaccine approaches. DNA vaccines encode certain proteins associated with a target pathogen, rather than using any part of the pathogen itself, and can prime the immune system as well as induce antibody and T-cell immune responses. DNA vaccines contain no viral particles, are non-infectious, and can be administered on a repeat basis without unwanted imm
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SOURCE Vical Incorporated
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