Navigation Links
S*BIO Initiates U.S. Phase I Clinical Trials of Oral JAK2 Inhibitor SB1518 for the Treatment of Hematological Malignancies
Date:9/17/2008

SINGAPORE, Sept. 18 /PRNewswire/ -- S*BIO Pte Ltd today announced the initiation of multi-center Phase I clinical trials of SB1518, a potent and orally-active JAK2 inhibitor, in patients with leukemia and certain types of lymphoma. These first Phase I trials for SB1518 comprise of ascending dose studies conducted at several leading clinical sites in the United States. The trials are expected to enroll up to 60 patients and are designed to determine the maximum tolerated dose and to assess the pharmacokinetics and overall safety profile of SB1518.

SB1518 is a small molecule JAK2-selective kinase inhibitor which has high potency against both the wild-type JAK2 kinase and the JAK2 kinase with the V617F mutation. The V617F mutation is found in high frequencies in various myeloproliferative disorders such as idiopathic myelofibrosis. SB1518 might also provide an effective treatment for other hematological malignancies with mutations and re-arrangements in the JAK2 gene.

"The entry of SB1518 into the clinical phase marks an important milestone for S*BIO and potentially offers a new targeted therapy for this group of difficult-to-treat patients that represent a significant unmet medical need," said Dr. Jan-Anders Karlsson, CEO of S*BIO. "SB1518 has demonstrated exciting anti-proliferative and anti-tumor activity, combined with excellent tolerability in relevant in vitro and in vivo models. We are pleased to conduct our company's first clinical trials in the United States at well respected centers such as The University of Texas M.D. Anderson Cancer Center, the University of Chicago Medical Center and the Fred Hutchinson Cancer Research Center."

In addition to SB1518, S*BIO has a robust pipeline including SB939, the company's lead histone deacetylase (HDAC) inhibitor, which is currently in Phase I trials in Singapore and Canada. S*BIO's target-driven approach to developing innovative small molecule therapies for cancer is built on a profound unde
'/>"/>

SOURCE S*BIO Pte Ltd
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. S*BIO to Develop New JAK-2 Inhibitor for Treatment of Myeloproliferative Disorders and Hematological Malignancies
2. Enanta Initiates Phase 1 Study on EDP-322, an Oral Antibiotic With Activity Against Hospital- and Community-Acquired MRSA
3. QuatRx Initiates Second Phase 3 Study of Ophena(TM) (Ospemifene Tablets) in Women With Postmenopausal Vaginal Syndrome
4. Cystic Fibrosis Axentis Pharma Initiates Clinical Trial for Lung Infections
5. Sangamo BioSciences Initiates Phase 2 Clinical Trial of Treatment for Amyotrophic Lateral Sclerosis (ALS)
6. Healthpoint Initiates Randomized, Double-Blind Study to Evaluate Effectiveness of Collagenase SANTYL(R) Ointment on Wound Healing
7. Enobia Pharma Initiates Clinical Testing of Enzyme Replacement Therapy to Treat Hypophosphatasia
8. Isis Initiates Clinical Trial of CRP Drug
9. Tolerx Initiates Dosing of Otelixizumab, a Novel Type 1 Diabetes Agent, in DEFEND, a Phase 3 Clinical Trial
10. Aegera Initiates a Fifth Phase 1 and 2 Clinical Trial for AEG35156
11. Alexza Initiates Second Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... , Aug. 29, 2014 Pomerantz LLP ... S.A. ("EDAP" or the "Company") (NASDAQ: EDAP ) ... in United States District Court, Southern District of ... is on behalf of a class consisting of all ... 1, 2013 and July 30, 2014, inclusive (the "Class ...
(Date:8/29/2014)... 29, 2014   Mast Therapeutics, Inc. ... today that Santosh Vetticaden, Chief Medical Officer and ... for personal reasons, in mid-September.  Edwin L. ... Aires Pharmaceuticals, which Mast acquired earlier this year, ... Company,s interim Chief Medical Officer.  Dr. Parsley previously ...
(Date:8/29/2014)... -- Thoratec Corporation (NASDAQ: THOR ), a ... save, support and restore failing hearts, said today it ... Healthcare Conference on Wednesday, September 10. ... will provide an update on the company, beginning at ... Time).   A webcast of the presentation ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against EDAP TMS S.A. and Certain Officers - EDAP 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against EDAP TMS S.A. and Certain Officers - EDAP 3Mast Therapeutics Announces Management Change 2Mast Therapeutics Announces Management Change 3Mast Therapeutics Announces Management Change 4
... Oct. 15 VWR International, LLC today celebrates the official ... Corporate Center in Radnor, PA. The new facility not only ... the opportunity for increased staffing as the company grows. ... supply and distribution companies, with worldwide sales in excess of ...
... The Pharmacy Technician Certification Board (PTCB) is proud to ... Pharmacy Seminar (JFPS) in Chattanooga, Tenn., October 18–21, 2010. ... Navy, Air Force and Coast Guard pharmacy community. Pharmacists ... retired communities, as well as civilian pharmacists and technicians ...
Cached Medicine Technology:VWR Opens New Global Headquarters in Radnor, PA 2VWR Opens New Global Headquarters in Radnor, PA 3PTCB Sponsors Joint Forces Pharmacy Seminar Challenge Coin 2
(Date:8/31/2014)... Richmond, CA (PRWEB) August 31, 2014 ... program of the California State Library, celebrates 30 ... and their families. Since its inception, California’s Library ... a million Californians learn to read and write. ... this volunteer-based program, the state is launching a ...
(Date:8/31/2014)... 2014 The severity of menopausal symptoms ... in menopause is expert in helping patients find ... from uncomfortable symptoms with the latest treatment options, including ... a variety of alternative treatments and products that can ... options may fall outside of what can be called ...
(Date:8/31/2014)... Spain Sunday 31 August 2014: Drinking tea reduces ... 000 people presented at ESC Congress today by Professor ... you have to choose between tea or coffee it,s ... important components of our way of life. Their effects ... past with sometimes divergent results. We investigated the effects ...
(Date:8/30/2014)... 2014: Local anaesthetic is as safe and effective for ... to results of the FRANCE 2 registry presented at ... , Dr Chopard said: "Numerous studies have shown that ... severe symptomatic aortic stenosis who are at very high ... The number of TAVI procedures in France and around ...
(Date:8/30/2014)... Orlando, Florida (PRWEB) August 31, 2014 ... gait walking and how a mobility device can help in ... now available for free download from the website that contains ... medical doctor for this site. , The articles deal with ... mobility device like a walking cane can help in making ...
Breaking Medicine News(10 mins):Health News:California Library Literacy Services Celebrates 30th Anniversary 2Health News:California Library Literacy Services Celebrates 30th Anniversary 3Health News:A Look at Complementary Therapies and Alternative Medicine for National Menopause Awareness Month 2Health News:A Look at Complementary Therapies and Alternative Medicine for National Menopause Awareness Month 3Health News:A Look at Complementary Therapies and Alternative Medicine for National Menopause Awareness Month 4Health News:A Look at Complementary Therapies and Alternative Medicine for National Menopause Awareness Month 5Health News:Drinking tea reduces non-CV mortality by 24 percent 2Health News:Drinking tea reduces non-CV mortality by 24 percent 3Health News:Local anesthetic for TAVI as safe and effective as general anesthetic 2Health News:Information Articles on Gait Problems from Walking-Canes.Net 2
... of Medicine (IOM) recently released a study, The Future ... calls for new and expanded roles for nurses in ... education for all nurses and allowing nurses to practice ... It advocates overhauling state scope of practice acts and ...
... was diagnosed in 2007 with acute multiple myeloma, a form ... troubles all those who receive an upsetting diagnosis. The way ... however, was different. Barrager drew upon his engineering and management ... is sharing his insights with hospitals and doctors in his ...
... Steven Reinberg HealthDay Reporter , MONDAY, Nov. ... pandemic H1N1 flu last year in California, more than ... California Department of Public Health researchers report. , ... to occur at similar rates as with seasonal influenza, ...
... News) -- Military veterans with psychiatric illnesses are at ... The greatest risk is among males with bipolar disorder ... researchers at the U.S. Department of Veterans Affairs and ... Overall, bipolar disorder (the least common diagnosis at 9 ...
... , MONDAY, Nov. 1 (HealthDay News) -- Any ... removed from play until evaluated by a physician who ... a new position statement issued by the American Academy ... recommendations directed at policymakers who develop procedures to be ...
... MONDAY, Nov. 1 (HealthDay News) -- Stroke patients are more ... the weekend instead of a weekday, regardless of the severity ... analyzed data from almost 21,000 stroke patients admitted to 11 ... their first stroke were included in the study. Seven ...
Cached Medicine News:Health News:ACP's response to the IOM's report the future of nursing: Leading change, advancing health 2Health News:ACP's response to the IOM's report the future of nursing: Leading change, advancing health 3Health News:ACP's response to the IOM's report the future of nursing: Leading change, advancing health 4Health News:ACP's response to the IOM's report the future of nursing: Leading change, advancing health 5Health News:ACP's response to the IOM's report the future of nursing: Leading change, advancing health 6Health News:Management science guru, surviving cancer, offers hope to fellow sufferers, doctors 2Health News:Management science guru, surviving cancer, offers hope to fellow sufferers, doctors 3Health News: Pandemic H1N1 Flu Hit Kids Hard in 2009 2Health News: Pandemic H1N1 Flu Hit Kids Hard in 2009 3Health News:Bipolar Disorder Tied to High Suicide Risk in Veterans 2Health News:Concussion Should Sideline Athletes: Neurologists 2Health News:Weekend Admissions Worse for Stroke Victims: Study 2
... Compact and durable, the Medelec ... Whether your choice of a smaller ... your need to take your testing ... Notebook is the solution. The 2, ...
The Nicolet Bravo is a Multi-application system that can configure to meet the needs of neurophysiology deparent....
... Myoquick 1200/1400/1800 units are based ... adopt the ISA 100x EP ... can select input units with ... 1002 EP), 4 channels (ISA ...
Sierra II power & efficiency plus. Sierra II report generator with automatic sentence generation creates the one-minute report. Complete 2/4 channel EMG/NCV/EP....
Medicine Products: