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Rubicon Genomics Launches ThruPLEX™ Family of Sample Preparation Products for Next Generation Sequencing Applications
Date:5/16/2012

ANN ARBOR, Mich., May 16, 2012 /PRNewswire/ -- Rubicon Genomics, Inc., a leader in the development and commercialization of sample-specific pre-analytical processes to improve the performance and capabilities of DNA and RNA analytical platforms for research and clinical testing, today announced the launch of the first product in its innovative ThruPLEX™ family of sample preparation kits designed and optimized for next generation sequencing (NGS).  ThruPLEX-FD kits leverage Rubicon's patented DNA repair and ligation methods to deliver significantly faster and more sensitive sequencing of plasma, formalin-fixed, ChIP and other fragmented DNA with substantially increased throughput.  ThruPLEX kits are also applicable to sample preparation for PCR and microarray testing.

"The accelerated adoption of NGS technology has created a demand for faster and more sensitive sample preparation," noted James Koziarz, CEO of Rubicon.  "Breaking with the traditional multi-step process requiring intermediate transfers and purifications, ThruPLEX uses more efficient enzymology to repair, ligate and amplify the DNA molecules in a single tube.  Our patented three-step process enables high quality sequencing of clinical samples that were previously too small or degraded to be tested."

Henry Long, Ph.D., Associate Director of the Center for Functional Cancer Epigenetics at the Dana-Farber Cancer Institute, commented, "Our experience with the ThruPLEX-FD library prep has been extremely positive.  Both at Rubicon and in our hands it has proven able to generate high quality, diverse libraries from 10-times less input than other kits we have used.  For us this technology truly enables the study of samples that simply weren't possible before adopting it."

ThruPLEX-FD is a streamlined one-tube, three-step process without intermediate purifications, transfers, columns or gels.  The reduced steps and material transfers decrease
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SOURCE Rubicon Genomics, Inc.
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