Navigation Links
Rotigotine Transdermal System Shows Significant Symptom Reduction and Tolerability in Patients with Restless Legs Syndrome
Date:10/8/2007

cally relevant reduction in the CGI Item-1 (severity of

illness) score compared to placebo

* The mean baseline scores were: IRLS 23.3 plus or minus 5.0 and CGI 4.7

plus or minus 0.7, reflecting moderate-to-severe symptoms at baseline

* The net effects over placebo after six months of treatment were -2.2

plus or minus 1.2, -2.3 plus or minus 1.2, -4.5 plus or minus 1.2

(p<0.001), -5.2 plus or minus 1.2 (p<0.001) in the IRLS and -0.35 plus

or minus 0.19, -0.32 plus or minus 0.19, -0.65 plus or minus 0.19

(p<0.001), -0.90 plus or minus 0.19 (p<0.001) in CGI Item-1 for

rotigotine 0.5, 1, 2, and 3 mg/24 hours respectively

* Rotigotine was also shown to be generally well-tolerated

* The most common adverse events were application site reactions (27.2%),

nausea (21.5%), headache (17.6%) and somnolence (12.6%)

24-Month, Open-Label Extension Trial in RLS

SP 710

* In an open-label extension of a double-blind, placebo-controlled, Phase

II dose-finding study conducted at multiple centers in Europe,

rotigotine, administered with optimal dose titration, showed long-term

therapeutic efficacy in patients with moderate-to-severe idiopathic RLS

who were treated for 24 months

* A total of 295 patients entered the open-label extension trial and 191

(65%) completed the two-year maintenance period of this ongoing trial

* After 24 months of open-label rotigotine treatment, 87% of patients were

rated as only mildly ill, borderline symptomatic, or normal on the CGI

Item-1 scale which rates overall severity of illness

* The "change of condition" CGI Item-2 score showed a sustained

improvement from the beginning through to the 24th month of open-label

maintenance

* Additionally, the "severity at bedtime falling asleep" score (RLS-6 Item

2) improved by 4.0 plus or minus 3.1 p
'/>"/>

SOURCE UCB, Inc.
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5

Related medicine technology :

1. TransPharma Medical Announces Positive Results of Phase I Clinical Trials for Transdermal Delivery of hPTH (1-34) for Osteoporosis Treatment
2. NuPathe Reports Positive Phase One Results for NP101 Transdermal Therapy for Acute Migraine
3. Daytrana (methylphenidate transdermal system) Provides Significant Effectiveness in ADHD Symptom Relief in Both Boys and Girls
4. 12-Month Study Demonstrated Tolerability and Efficacy of DAYTRANA (methylphenidate transdermal system)
5. Phosphagenics to Commence Phase 1b Transdermal Insulin Clinical Trial in Second Quarter
6. When Volume Matters, Immunoassay Systems Deliver
7. Genetic Analysis Systems Enter the Clinical Mainstream
8. New Quality Control Systems for Every Laboratory Application
9. Immunoassay Systems - Your Laboratory Workhorse
10. Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting Systems Success in Mouse Model Reported in Cancer Cell
11. Researchers Discover Method for Identifying How Cancer Evades the Immune System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... CHESTERBROOK, Pa. , May 24, 2013  Auxilium ... that executive management will participate in the Deutsche Bank ... the Westin Boston Waterfront Hotel.  Mr. Adrian ... scheduled to present an overview of the Company and ... May 29, 2013.   (Logo: http://photos.prnewswire.com/prnh/20101202/MM10881LOGO ...
(Date:5/24/2013)... , May 24, 2013 ... administration for systemic delivery of therapeutic agents has been ... inhalation drug delivery showing significant promise. The crucial formulation ... a delivery device play a major role in the ... made in the development of new formulation techniques and ...
(Date:5/23/2013)... 23, 2013  Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: ... the 2013 Life Science Firm of the Year by the ... was honored at the TCM,s 25 th Annual Tech ... The Tech Awards Celebration recognizes the leaders and innovators in ... and the surrounding regions. "We ...
Breaking Medicine Technology:Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 2Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 3Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 4Inhalaltion Drug Delivery: 11-12 September - Berlin, Germany 2Vanda Pharmaceuticals Named the 2013 Life Science Firm of the Year by the Tech Council of Maryland 2
... large, randomized Phase III study of ERBITUX ... neck cancer,meets primary endpoint of improving overall ... /PRNewswire-FirstCall/ -- ImClone,Systems Incorporated and Bristol-Myers Squibb ... III study of ERBITUX(R) (Cetuximab),combined with platinum-based ...
... --,SuperGen Inc. announced today that it will have ... Meeting on April 14-18 in Los Angeles. These ... current oncology,programs including its lead tyrosine kinase inhibitor ... key protein target involved,in cancer cell drug resistance. ...
Cached Medicine Technology:Survival Data Available From Erbitux Study in First-Line Treatment,of Advanced Head and Neck Cancer 2Survival Data Available From Erbitux Study in First-Line Treatment,of Advanced Head and Neck Cancer 3Survival Data Available From Erbitux Study in First-Line Treatment,of Advanced Head and Neck Cancer 4Survival Data Available From Erbitux Study in First-Line Treatment,of Advanced Head and Neck Cancer 5Survival Data Available From Erbitux Study in First-Line Treatment,of Advanced Head and Neck Cancer 6Survival Data Available From Erbitux Study in First-Line Treatment,of Advanced Head and Neck Cancer 7Survival Data Available From Erbitux Study in First-Line Treatment,of Advanced Head and Neck Cancer 8Survival Data Available From Erbitux Study in First-Line Treatment,of Advanced Head and Neck Cancer 9SuperGen to Highlight Oncology Pipeline Data in Multiple,Presentations at AACR 2SuperGen to Highlight Oncology Pipeline Data in Multiple,Presentations at AACR 3SuperGen to Highlight Oncology Pipeline Data in Multiple,Presentations at AACR 4
(Date:5/24/2013)... 2013 Gift Card Network members ... in sustainable card material, are combining forces to ... as a sustainable gift card substrate. , The ... challenges and increase education and usage of these ... the reduction of carbon footprint and environmental impact ...
(Date:5/24/2013)... Area homeowners dreaming about owning a hot ... to choose from at factory-direct pricing during the Jacuzzi ... takes place at Emerald Pool and Patio in ... the industry's leading hot tub brand, scheduled the event as ... event will feature popular hot tub models at up to ...
(Date:5/24/2013)... Dwell Media LLC announces the ... Vice President of Digital for Dwell Media. At Yahoo, ... large portion of Yahoo's global media business. At Dwell, ... fully-integrated commerce unit to launch in 2014. Huff brings ... for leading firms in Silicon Valley. Dwell, which has ...
(Date:5/24/2013)... 2013 6Webs.com has educated thousands of ... home security monitoring provider. The easy to ... useful resource consumers prefer for unbiased and impartial home ... of the leading wireless home security system providers in ... on a number of key factors including reliability, technology ...
(Date:5/24/2013)... New York, New York (PRWEB) May 24, 2013 ... 101 Mobility® is a leading nationwide ... accessibility solutions for both consumer and commercial applications. ... ramps, vertical platform lifts, vehicle lifts for mobility ... elevators, among others. 101 Mobility operates over 30 ...
Breaking Medicine News(10 mins):Health News:Making Gift Cards Greener- Competitors Combine Efforts to Educate and Empower Merchants 2Health News:Making Gift Cards Greener- Competitors Combine Efforts to Educate and Empower Merchants 3Health News:Truckload of Jacuzzi® Hot Tubs Rolls into Bend, Oregon on May 24, 2013 for Sales Event 2Health News:Yahoo Commerce Head Joins Leadership at Dwell Media 2Health News:2013 Best Wireless Security System Providers Reported by 6Webs.com 2Health News:Cortec Closes Equity Transaction with 101 Mobility 2
... In the first ever threadbare genetic study of Alzheimer’s, reports ... 79% of the cases, is genetically linked. // ... to it. The disease is marked by apparent confusion, memory ... a place in the Archives of General Psychiatry,However genes cannot ...
... has been an increase in heart failure cases among the elderly, ... men surviving for longer periods. There has been a 14% increase ... period when compared to the 1970 to 1974 period, in the ... ,The chances of heart failure occurring among people ...
... produced by Roche Pharmaceuticals, has been approved by the ... prevention drug in children’s between the ages of 1 ... leading healthcare company situated in Switzerland and are manufacturers ... to be an effective influenza virus drug, which inhibits ...
... leaders, particularly in South Asia to prohibit smoking among the ... the British Medical Journal (BMJ). The help of the Muslim ... ,The researchers analyzed data on the prevalence of smoking ... Smoking rates in each of these countries is significantly higher ...
... who suffer from eating disorders do not reveal it to anyone ... six months. As many as 1,000 youngsters were studied, and the ... of recognizing such disorders in their children, while only 21% of ... ,The research was conducted by the Eating Disorders Association ...
... charges cost so dear, that cancer patients, ill afford ... Charity Breast Cancer Care, 42% of breast cancer patients, ... financial incapacity to afford the prescription charges. Out of ... 15% said they were forced to discontinue the treatment ...
Cached Medicine News:Health News:Eating Disorders Among Children Are Widespread 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: