Navigation Links
Rotigotine Transdermal System Shows Significant Symptom Reduction and Tolerability in Patients with Restless Legs Syndrome
Date:10/8/2007

cally relevant reduction in the CGI Item-1 (severity of

illness) score compared to placebo

* The mean baseline scores were: IRLS 23.3 plus or minus 5.0 and CGI 4.7

plus or minus 0.7, reflecting moderate-to-severe symptoms at baseline

* The net effects over placebo after six months of treatment were -2.2

plus or minus 1.2, -2.3 plus or minus 1.2, -4.5 plus or minus 1.2

(p<0.001), -5.2 plus or minus 1.2 (p<0.001) in the IRLS and -0.35 plus

or minus 0.19, -0.32 plus or minus 0.19, -0.65 plus or minus 0.19

(p<0.001), -0.90 plus or minus 0.19 (p<0.001) in CGI Item-1 for

rotigotine 0.5, 1, 2, and 3 mg/24 hours respectively

* Rotigotine was also shown to be generally well-tolerated

* The most common adverse events were application site reactions (27.2%),

nausea (21.5%), headache (17.6%) and somnolence (12.6%)

24-Month, Open-Label Extension Trial in RLS

SP 710

* In an open-label extension of a double-blind, placebo-controlled, Phase

II dose-finding study conducted at multiple centers in Europe,

rotigotine, administered with optimal dose titration, showed long-term

therapeutic efficacy in patients with moderate-to-severe idiopathic RLS

who were treated for 24 months

* A total of 295 patients entered the open-label extension trial and 191

(65%) completed the two-year maintenance period of this ongoing trial

* After 24 months of open-label rotigotine treatment, 87% of patients were

rated as only mildly ill, borderline symptomatic, or normal on the CGI

Item-1 scale which rates overall severity of illness

* The "change of condition" CGI Item-2 score showed a sustained

improvement from the beginning through to the 24th month of open-label

maintenance

* Additionally, the "severity at bedtime falling asleep" score (RLS-6 Item

2) improved by 4.0 plus or minus 3.1 p
'/>"/>

SOURCE UCB, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. TransPharma Medical Announces Positive Results of Phase I Clinical Trials for Transdermal Delivery of hPTH (1-34) for Osteoporosis Treatment
2. NuPathe Reports Positive Phase One Results for NP101 Transdermal Therapy for Acute Migraine
3. Daytrana (methylphenidate transdermal system) Provides Significant Effectiveness in ADHD Symptom Relief in Both Boys and Girls
4. 12-Month Study Demonstrated Tolerability and Efficacy of DAYTRANA (methylphenidate transdermal system)
5. Phosphagenics to Commence Phase 1b Transdermal Insulin Clinical Trial in Second Quarter
6. When Volume Matters, Immunoassay Systems Deliver
7. Genetic Analysis Systems Enter the Clinical Mainstream
8. New Quality Control Systems for Every Laboratory Application
9. Immunoassay Systems - Your Laboratory Workhorse
10. Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting Systems Success in Mouse Model Reported in Cancer Cell
11. Researchers Discover Method for Identifying How Cancer Evades the Immune System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... 16, 2014 Research and Markets ... "Global Laparoscopy Devices Industry Report 2014" report ... Laparoscopy Devices Industry Report 2014 is a professional ... the global laparoscopic devices. The report ... definitions, classifications, applications and industry chain structure. The ...
(Date:9/16/2014)... Sept. 16, 2014 Based on its ... Frost & Sullivan recognises Incisive Surgical with the ... Value Leadership. Incisive Surgical,s uniquely-designed, innovative INSORB® Absorbable ... eliminates the need for patients to undergo the ... removal  that may result in increased pain, wound ...
(Date:9/16/2014)... DIEGO , Sept. 16, 2014 Imprimis ... pharmaceutical company dedicated to delivering high quality and novel ... announced that Chief Executive Officer Mark Baum ... Annual Craig-Hallum Alpha Select Conference in New York City.  ... its Go Dropless™ campaign in ophthalmology. The presentation ...
Breaking Medicine Technology:Global Laparoscopy Devices Industry Report 2014 2Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 2Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 3Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 4Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 5Imprimis Pharmaceuticals to Present at Craig-Hallum Alpha Select Conference 2Imprimis Pharmaceuticals to Present at Craig-Hallum Alpha Select Conference 3Imprimis Pharmaceuticals to Present at Craig-Hallum Alpha Select Conference 4
... Md., Aug. 1, 2011 /PRNewswire-USNewswire/ – CoMeD ... Nations Environment Programme (UNEP) distributed a revised ...  Advocates for mercury-free drugs were gratified to see pharmaceuticals ... the proposed treaty. The Coalition for ...
... 2011 Reportlinker.com announces that a new ... catalogue: Patient Self-Monitoring: Devices, ...   http://www.reportlinker.com/p0581171/Patient-Self-Monitoring-Devices-Markets-Players-and-Prospects .html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic ... monitor their own serum levels is deemed ...
Cached Medicine Technology:Global Mercury Treaty May Include Ban on Mercury in Medicine 2Global Mercury Treaty May Include Ban on Mercury in Medicine 3Patient Self-Monitoring: Devices, Markets, Players and Prospects 2Patient Self-Monitoring: Devices, Markets, Players and Prospects 3
(Date:9/16/2014)... September 16, 2014 Not all recovery ... take care to make sure all their patients are ... some, this may include the newly-introduced online therapy. Millennium ... which gives patients the opportunity to seek treatment from ... provide medical and clinical care at a distance. They ...
(Date:9/16/2014)... WA (PRWEB) September 16, 2014 Duke’s Chowder ... Seattle startups Rebls and Gratafy for a ... and startup hub is firmly cemented. With the growth of companies ... of opportunities for people who work in tech and at startups ... Rebls and Gratafy are happy to host events for their peers ...
(Date:9/16/2014)... A new clinical trial comparing the ... balloons (DEB) in treating in-stent restenosis (ISR) ... superior late angiographic results and better late ... today at the 26th annual Transcatheter Cardiovascular ... Cardiovascular Research Foundation (CRF), TCT is the ...
(Date:9/16/2014)... 16, 2014 Programs and policies that ... of billions of dollars in savings for the US ... Commonwealth Fund. To help spur these types of improvements, ... 10 collaborative groups from across the country to field ... ) - a handbook designed to assist groups working ...
(Date:9/16/2014)... AcousticSheep LLC, makers of the most ... Wireless, their latest version of RunPhones® headphones. RunPhones® Wireless ... active people seeking a safe, comfortable headphone. They ... market and will be available October 1, 2014. ... of the same great features as its predecessor, RunPhones® ...
Breaking Medicine News(10 mins):Health News:Millennium Treatment Group Now Offers Online Therapy 2Health News:Seattle Seafood Restaurant Duke’s Chowder House Partners with Rebls & Gratafy for Tech Networking Happy Hour Event. 2Health News:Seattle Seafood Restaurant Duke’s Chowder House Partners with Rebls & Gratafy for Tech Networking Happy Hour Event. 3Health News:Results of RIBS IV trial reported at TCT 2014 2Health News:NQF Seeks Field Testing Groups for Population Health Guide 2Health News:NQF Seeks Field Testing Groups for Population Health Guide 3Health News:RunPhones® Prepares to Launch Their New Highly Anticipated Wireless Headphones 2Health News:RunPhones® Prepares to Launch Their New Highly Anticipated Wireless Headphones 3
... The Consumer-Purchaser,Disclosure Project --- a group of leading ... all Americans have access to publicly,reported health care ... General of New York and Cigna Healthcare to ... will,allow physician performance measurement and reporting to proceed ...
... Remind Me Today! reminder program, TORONTO, Oct. 29 ... program - a free telephone-based reminder program designed to,help ... Canada, over 1.3 million women (Stat. Can., 2001) take ... who hasn,t,forgotten to take it at least once. Although ...
... Key Element To An Effective, Hygiene Protocol. ... WASHINGTON, Oct. 29 The recent outbreak ... as an important,reminder of the importance of routine, ... large number of people constantly live,work or play. ...
... may affect heart despite symptom relief, experts say , , ... live longer than they did 40 years ago, but not ... from the Mayo Clinic. , "When you look at persons ... the benefits over the last several decades of improved survival ...
... Patients with chronic tendinosis of the Achilles tendon can ... small amount of a dextrose solution, according to a ... in Vancouver, BC. , Chronic tendinosis is a common ... and can affect many tendons throughout the body, said ...
... announced results from a recent economic analysis of Synagis ... of care for prevention of severe lower respiratory tract ... infants. Released at the American Academy of Pediatrics (AAP) ... costs of providing Synagis to premature infants, as well ...
Cached Medicine News:Health News:Consumers, Health Care Purchasers Applaud Agreement On Physician Performance Reporting 2Health News:Consumers, Health Care Purchasers Applaud Agreement On Physician Performance Reporting 3Health News:Consumers, Health Care Purchasers Applaud Agreement On Physician Performance Reporting 4Health News:Canada leads the way in contraceptive compliance 2Health News:Canada leads the way in contraceptive compliance 3Health News:Spate of Staph Infections Highlight the Need for Thorough, Consistent Cleaning Regimen at Home, at School and at Work 2Health News:Rheumatoid Arthritis Death Rate Unchanged 2Health News:Rheumatoid Arthritis Death Rate Unchanged 3Health News:Ultrasound-guided injections help ease chronic Achilles tendon pain 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: