Navigation Links
Rotigotine Transdermal System Shows Significant Symptom Reduction and Tolerability in Patients with Restless Legs Syndrome
Date:10/8/2007

- Data Presented at the 132nd Annual Meeting of the American Neurological

Association in Washington, D.C. -

ATLANTA, Oct. 8 /PRNewswire/ -- UCB, Inc. presented results from two Phase III pivotal trials and one open-label extension trial of rotigotine transdermal system for the treatment of moderate-to-severe restless legs syndrome (RLS). These rotigotine data showed significant drops in RLS symptoms, including changes of up to 8 points over placebo using the International Restless Legs Syndrome Study Group Rating Scale (IRLS) and a reduction in disease severity over a two-year period.

"Given the strong efficacy and tolerability seen to date, rotigotine, if approved, would provide a new and valuable alternative for many patients negatively impacted by the symptoms of moderate-to-severe RLS," said Wayne Hening, M.D., a lead study investigator and Assistant Clinical Professor of Neurology at the Robert Wood Johnson Medical School.

In the two six-month, double-blind, placebo-controlled trials, rotigotine produced clinically relevant and statistically significant reductions in RLS symptoms compared to placebo and was generally well-tolerated. An additional presentation highlighted a two-year interim analysis of a long-term, open- label extension of rotigotine for moderate-to-severe RLS, representing some of the longest safety follow-up information for a dopamine agonist in RLS to date.

In these studies, the efficacy of rotigotine was evaluated by monitoring several clinician-administered scales including the IRLS, the Clinical Global Impressions (CGI) and the Restless Leg Syndrome-6 (RLS-6). The IRLS scale measures the severity and frequency of RLS symptoms and the degree to which they affect sleep and daily life (IRLS: 0 = no symptoms and 40 = very severe symptoms). The CGI scale measures the general severity of an illness, clinical improvement or efficacy of treatment parameters. On the RLS-6 scale, patients rate the
'/>"/>

SOURCE UCB, Inc.
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5

Related medicine technology :

1. TransPharma Medical Announces Positive Results of Phase I Clinical Trials for Transdermal Delivery of hPTH (1-34) for Osteoporosis Treatment
2. NuPathe Reports Positive Phase One Results for NP101 Transdermal Therapy for Acute Migraine
3. Daytrana (methylphenidate transdermal system) Provides Significant Effectiveness in ADHD Symptom Relief in Both Boys and Girls
4. 12-Month Study Demonstrated Tolerability and Efficacy of DAYTRANA (methylphenidate transdermal system)
5. Phosphagenics to Commence Phase 1b Transdermal Insulin Clinical Trial in Second Quarter
6. When Volume Matters, Immunoassay Systems Deliver
7. Genetic Analysis Systems Enter the Clinical Mainstream
8. New Quality Control Systems for Every Laboratory Application
9. Immunoassay Systems - Your Laboratory Workhorse
10. Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting Systems Success in Mouse Model Reported in Cancer Cell
11. Researchers Discover Method for Identifying How Cancer Evades the Immune System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2013)... -- Unilife Corporation ("Unilife" or "Company") (NASDAQ: UNIS, ASX: ... injectable drug delivery systems, today announced the launch of ... new site includes additional products, videos, features, blogs and ... basis. Mr. Alan Shortall , the ... for injectable drug delivery systems, we have created an ...
(Date:6/18/2013)... 18, 2013  Women are frequently the healthcare advocate ... often do not give the same priority to their ... from their doctor because they were too embarrassed or ... recent survey conducted by Allergan and endorsed by the ... education, funding and research to the field of women,s ...
(Date:6/18/2013)... BURLINGTON, Mass. , June 18, 2013 /PRNewswire/ ... and advisory firms for pharmaceutical and healthcare issues, ... includes coverage of the Middle East ... Market Access Tracker analyzes the challenges and opportunities ... in four international regions comprising 24 countries. The ...
Breaking Medicine Technology:Unilife Launches New Corporate Website 2New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 2New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 3New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 4New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 5New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 6New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 7New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 8New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 9Decision Resources' Market Access Tracker Now Covers the Middle East and Africa 2Decision Resources' Market Access Tracker Now Covers the Middle East and Africa 3
(Date:6/18/2013)... The Temp1000IS temperature data logger is ... be used to automatically record temperatures between -20 and ... comes with the serial number and device name engraved. ... separately) docking station and can be placed directly into ... of end-caps to download data. The small size of ...
(Date:6/18/2013)... Palo Alto has taken yet another step ... with its recent major long-term solar power commitment. , ... electric power purchase agreements , which together will result in ... photovoltaic electric power per year, which is the equivalent of ... enough power to supply all 65,000+ Palo Alto residents---and then ...
(Date:6/18/2013)... Internationally acclaimed plastic surgeon, Dr. John ... his unique approach to breast augmentation. Dr. Tebbetts’ ... method and highlights the results of Dr. Tebbetts’ ... Tebbetts compares his breast augmentation method to other ... does not necessitate the use drains, bandages, narcotic ...
(Date:6/18/2013)... signaling network between two previously unconnected proteins, exposing a ... growth at its starting point. , A team led ... Cancer Center reported the tie between epidermal growth factor ... a protein vital to the first step in DNA ... . , "MCM7 overexpression marks cell proliferation and is ...
(Date:6/18/2013)... 2013 myCNAjobs announces the addition of ... articles, and tips to the Caregiver Resources Center. , ... the 10,000+ retiring baby boomers each day, the need ... job resources has never been greater. myCNAjobs, ... community, recently launched the first-ever free resource center for ...
Breaking Medicine News(10 mins):Health News:MadgeTech, Inc. Introduces the New Temp1000IS Intrinsically Safe High Temperature Data Logger 2Health News:Palo Alto Seals the Deal on Major Solar Electric Investments 2Health News:Palo Alto Seals the Deal on Major Solar Electric Investments 3Health News:Internationally Acclaimed Breast Augmentation Expert Announces the Launch of His New Website 2Health News:Scientists catch EGFR passing a crucial message to cancer-promoting protein 2Health News:myCNAjobs Adds New Resources to Growing Caregiver Career Center 2
... an assistant professor at the University of Miami, School ... grant from the Robert Wood Johnson Foundation (RWJF) to ... dating violence among Hispanics. Gonzalez-Guarda is one of just ... the three-year $350,000 Nurse Faculty Scholar award this year. ...
... , WEDNESDAY, Sept. 7 (HealthDay News) -- Breast-feeding ... mothers who bottle-feed or women without children, researchers say. ... mothers and 20 non-mothers also found that aggression in ... This suggests that breast-feeding helps lower the body,s typical ...
... who have received high doses of chemotherapy may find ... research from the Sahlgrenska Academy at the University of ... chemotherapy treatment were two times higher than among those ... the scientific journal Acta Oncologica . Almost one ...
... concerns may prevent children from getting good exercise, according ... examined how families use neighborhood parks. Results ... too closely by hovering "helicopter" parents were less likely ... "It,s a catch-22 for today,s parents, unfortunately. Many ...
... By Ellin Holohan HealthDay Reporter , WEDNESDAY, Sept. ... jeopardize their children,s academic success and harm their family,s finances ... money on cigarettes, according to a new study. The ... with smokers have higher rates of respiratory illness and missed ...
... Reporter , TUESDAY, Sept. 6 (HealthDay News) -- Contrary ... and breast self-exams are useful for the detection of ... screening mammographies and evaluations of palpable masses are important ... co-author of a study to be presented at the ...
Cached Medicine News:Health News:UM Gonzalez-Guarda wins grant from Robert Wood Johnson Foundation 2Health News:UM Gonzalez-Guarda wins grant from Robert Wood Johnson Foundation 3Health News:Chemotherapy can impair speech 2Health News:Helicopter parents can impede child’s ability to play 2Health News:Parents Who Smoke at Home May Risk Kids' Academic Success 2Health News:Parents Who Smoke at Home May Risk Kids' Academic Success 3Health News:Annual Breast Exams, Mammograms Still Key to Detecting Breast Cancer 2Health News:Annual Breast Exams, Mammograms Still Key to Detecting Breast Cancer 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: