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Rosetta Genomics and M. D. Anderson to Develop a MicroRNA-based Diagnostic Test to Identify Risk of Recurrence of Lung Cancer
Date:6/6/2008

boration which may have a significant impact on the way lung cancer patients are diagnosed and treated."

Lung cancer is the leading cause of cancer death among both men and women worldwide and in the United States. In 2008 alone, there will be about 215,020 new cases of lung cancer in the United States, and approximately 160,000 people will die of the disease(1).

"We are quickly learning about the benefits of better diagnostics in optimizing treatment administration," said Ignacio I. Wistuba, M.D., associate professor, Department of Pathology at

M. D. Anderson Cancer Center. "Currently, the lack of sensitive diagnostic tools means lung cancer patients, who have undergone a resection, may be administered aggressive chemotherapy despite the fact that they are at low risk of the cancer recurring. By leveraging microRNAs' unique sensitivity as biomarkers, we have an opportunity to develop a novel test that will assist clinicians and patients to better manage this type of cancer."

"The use of miRNA with existing genomic and proteomic information will help us achieve the goal of personalization of the treatment," said Gordon Mills, co-director of the Kleberg Center for Molecular Markers, at M. D. Anderson Cancer Center.

"This is one of the many collaborations with industry leaders that the Kleberg Center is building to bring novel technologies to achieve our mission of affecting treatment changes," said Rahul Mitra, associate director of the Kleberg Center.

About microRNAs

MicroRNAs (miRNAs) are recently discovered, naturally occurring, small RNAs that act as master regulators and have the potential to form the basis for a new class of diagnostics and therapeutics. Since many diseases are caused by the abnormal activity of proteins, the ability to selectively regulate protein activity through microRNAs could provide the means to treat a wide range of human diseases. In addition, microRNAs have been shown to have different e
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SOURCE Rosetta Genomics Ltd
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