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Rosetta Genomics and Collaborators Identify MicroRNAs That Can Accurately Discriminate Between Primary and Metastatic Tumors in the Brain
Date:7/9/2008

Study Demonstrates Differentiation of Primary Tumors From Metastases in the

Brain With Accuracy Near 90% Identifying Whether a Brain Malignancy is a Primary Tumor or a Metastasis

is a Recurring Challenge for Pathologists Using Current Technologies Accurately Differentiating Primary From Metastatic Tumors is Critical for

Optimal Treatment

REHOVOT, Israel and JERSEY CITY, New Jersey, July 9 /PRNewswire-FirstCall/ -- Rosetta Genomics, Ltd. (NASDQ: ROSG), a leader in the development of microRNA-based diagnostic and therapeutic products, announced today that the results of a study conducted by its scientists and collaborators and describing the use of microRNAs in accurately differentiating primary from metastatic tumors of the brain, have been published online in the peer-reviewed journal Brain Pathology. The findings demonstrate microRNAs' significant potential to act as effective biomarkers that may be applied in a diagnostic test designed to identify primary tumors in patients with brain cancers.

"This latest study conducted by our scientists, as well as our previously published Nature Biotechnology paper, are further validation of microRNAs' vast potential to act as accurate biomarkers in various cancers," noted Dr. Dalia Cohen, Chief Scientific Officer of Rosetta Genomics. "We are continually optimizing our microRNA platform technologies to leverage them in the development of a wide range of microRNA-based diagnostics, primarily for cancer."

The study results, published in Brain Pathology, describe the development and validation of microRNA expression profiles for characterization of brain malignancies. Rosetta Genomics' scientists measured microRNA expression in RNA extracted from hundreds of formalin-fixed, paraffin-embedded (FFPE) samples of brain primary tumors and various other tissues, as well as 60 samples of metastatic brain tumors. Two microRNAs, miR-92b and miR-9/9*,
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SOURCE Rosetta Genomics Ltd
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