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Romark Initiates Clinical Trial of Alinia for Treatment of Influenza
Date:2/1/2010

TAMPA, Fla., Feb. 1 /PRNewswire/ -- Romark Laboratories announced that it has initiated enrollment of patients in a clinical trial of Alinia® (nitazoxanide) for treating acute uncomplicated influenza including illness caused by the currently circulating H1N1 strain.  

(Logo:  http://www.newscom.com/cgi-bin/prnh/20100201/FL47022 )

The clinical trial is being conducted in approximately 25 sites across the United States and is expected to enroll 440 adult patients with acute uncomplicated influenza.  The trial is designed to test the hypothesis that treatment with oral nitazoxanide administered 500 mg twice daily for 5 days will reduce the duration of symptoms of influenza.  The trial will also evaluate the effect of treatment on other parameters including the severity of symptoms, complications of influenza and time to return to normal activities.

This clinical trial follows a published report in the October 23, 2009 issue of the Journal of Biological Chemistry titled, "Thiazolides, A New Class of Anti-influenza Molecules Targeting Viral Hemagglutinin at the Post-Translational Level."  In the article, scientists reported that nitazoxanide (the active ingredient of Alinia) and other drugs from the class called thiazolides inhibit the replication of influenza A viruses including H1N1 and H5N9 (a low pathogenicity avian strain) and influenza B virus in laboratory studies by a novel mechanism.(1)

"This drug works differently than the drugs we currently use for treating influenza," said Professor '/>"/>

SOURCE Romark Laboratories, L.C.
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