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Romark Announces Data Presented at AASLD Meeting 2010
Date:11/1/2010

neau, W. Ray Kim; Mayo Clinic College of Medicine, Rochester, MN. Poster session: Sunday, October 31, 8:00 am – 5:30 pm.

Dr. Kim and his colleagues from the Mayo Clinic have reported results of a pilot study of nitazoxanide in 5 male liver transplant patients who received oral nitazoxanide 1000 mg b.i.d. immediately prior to transplant and for 72 hours thereafter.  Each of the 5 patients experienced a decrease in HCV viral load during the first 72 hours.  Within 4 days after completing therapy, HCV RNA levels were similar to pre-transplant levels.  Nitazoxanide was well tolerated with the primary adverse events being abdominal pain and nausea which resolved.  Post-transplant viral kinetics for these 5 patients were similar to a historical control group of 5 transplant recipients, except that there was a greater log drop in nitazoxanide-treated patients within the first 24 hours.  The authors concluded that this suggests that peri-transplant induction with nitazoxanide, potentially at a higher dose, may serve as a novel adjunct to other antiviral regimens to prevent HCV recurrence.

About Hepatitis C

Hepatitis C is a blood-borne infectious disease that is caused by the hepatitis C virus (HCV). It is the most common cause of chronic hepatitis in the U.S. and may eventually lead to cirrhosis, liver cancer and liver failure. The disease is transmitted by contact with HCV-infected blood.  A large majority of those infected do not show symptoms, but fatigue, abdominal pain and nausea can be common.  The current standard treatment of care, peginterferon and ribavirin, is effective in about half of all patients treated. Treatment outcomes vary based on a number of factors including genotype, viral load, genetic factors, stage of liver disease, co-infections and ability to adhere to treatment.  According to the Centers for Disease Control, approximately 3.2 million Americans are chronically infected wit
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SOURCE Romark Laboratories, L.C.
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