Navigation Links
Roche and Pharmasset To Present the R7128 Monotherapy Resistance Profile
Date:2/6/2008

-- Study concludes there was no evidence of the development of viral resistance to R7128 after 2 weeks of monotherapy in hepatitis C patients --

PRINCETON, N.J., Feb. 6 /PRNewswire-FirstCall/ -- Pharmasset (Nasdaq: VRUS) and Roche will present the R7128 monotherapy resistance profile at the EASL-AASLD-APASL-ALEH-IASL Conference on Hepatitis B & C Virus Resistance to Antiviral Therapies being held in Paris, France from February 14-16, 2008. The scientific abstract for poster board no. 36, entitled "Lack of Viral Resistance after 14-day Monotherapy Treatment with R7128 in Treatment-experienced Patients Infected with HCV Genotype 1," is currently available on the conference website at http://www.easl.ch/hepatitis-conference/program/session1.asp. The poster presentation will be available for download in PDF format after it is presented on February 14, 2008 in the "Events & Presentations" section of Pharmasset's website at http://investor.pharmasset.com/events.cfm.

About R7128

R7128 is being developed for the treatment of chronic HCV infection through Pharmasset's collaboration with Roche. R7128 is a prodrug of PSI-6130, a nucleoside analog inhibitor of HCV RNA polymerase. A prodrug is a chemically modified form of a molecule designed to enhance the absorption, distribution and metabolic properties of that molecule.

In a Phase 1 clinical trial, R7128 demonstrated potent, dose-dependent antiviral activity across four patient cohorts (n=40) receiving 750mg or 1500mg administered either once-daily or twice-daily for 2 weeks as monotherapy. The greatest mean decrease in HCV RNA from baseline was observed in the patient cohort that received 1500mg twice-daily, the highest dose of R7128 administered in the study. These patients experienced a mean 2.7 log10 IU/mL (>99%) decrease in HCV R
'/>"/>

SOURCE Pharmasset, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Roche responds to announcement of IDEAL hepatitis C trial results
2. Roche Submits Application for FDA Approval of ACTEMRA(R) for the Treatment of Rheumatoid Arthritis
3. Two Pivotal Phase III Studies for Roches ACTEMRA(TM) (tocilizumab) Demonstrate Significant Improvement in Rheumatoid Arthritis Symptoms
4. Roches Investigational Polymerase Inhibitor, Combined with PEGASYS(R) and COPEGUS(TM), Shows Potent Antiviral Activity in Treatment of Chronic Hepatitis C at Four Weeks
5. Roche Diagnostics HIV Viral Load Test Used in Clinical Trials for Isentress, a New Class of HIV Drug
6. Roche Announces Positive Results in Solid Tumors Using Human Monoclonal Antibody Against IGF-1R (R1507)
7. MacroChem Acquires Rights to Pexiganan, a Novel Topical Anti-Infective for Treatment of Diabetic Foot Infections, From Genaera
8. Rochester Medical Anti-Infection Foley Catheter Demonstrates Effectiveness in Randomized Trial
9. Researchers Identify Virus Possibly Responsible for Declining Honeybee Population Using 454 Sequencing Technology from Roche
10. Wyeths Torisel and Roche/Genentechs Avastin Will Challenge Pfizers Sutent to Become the Clinical Gold Standard for Treatment of Metastatic Renal Cell Carcinoma
11. Pharmasset Announces R7128 Achieves 85% Rapid Virologic Response in a 4-week Combination Study for the Treatment of Chronic Hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/29/2015)... KALAMAZOO, Mich. , June 29, 2015 /PRNewswire/ ... Association and American Stroke Association give hope for ... patients who experience an acute ischemic stroke each ... of the key products used in the clinical ... The new AHA/ASA guidelines strongly recommend endovascular ...
(Date:6/29/2015)... , June 29, 2015 ... positive preliminary results from its BVX-006 Phase II clinical ... vaccine. In this trial, M-001 was injected intramuscularly to ... by an administration of the 2014/15 season trivalent influenza ... be safe and well tolerated and induced humoral immune ...
(Date:6/29/2015)... Calif. , June 29, 2015  Isis Pharmaceuticals, ... has been added to the Russell 1000 Index, effective ... performance of the large-cap segment of the U.S. equity ... Index and includes approximately 1000 of the largest securities ... current index membership. "We are pleased to ...
Breaking Medicine Technology:New AHA Guidelines For The Early Management And Treatment Of Stroke Will Change The Standard Of Care For Thousands Of Stroke Patients Each Year 2New AHA Guidelines For The Early Management And Treatment Of Stroke Will Change The Standard Of Care For Thousands Of Stroke Patients Each Year 3BiondVax Presents BVX-006 Preliminary Phase II Results: the Universal Flu Vaccine at Higher Doses is Safe and Improves Immunogenicity in Older Adults 2BiondVax Presents BVX-006 Preliminary Phase II Results: the Universal Flu Vaccine at Higher Doses is Safe and Improves Immunogenicity in Older Adults 3ISIS Pharmaceuticals Promoted to the Large-Cap Russell 1000 Index 2ISIS Pharmaceuticals Promoted to the Large-Cap Russell 1000 Index 3
... JERUSALEM, Oct. 13, 2011 IDenta Corp. (OTC: IDTA) CEO ... Shoham stated, "We are succeeding in making sales in many ... products. We have received an order for 2000 ... http://www.gksolutions.com.au/ In the past several ...
... Association for Homecare urges the Joint Select Committee on ... cuts that will restrict access to home medical ... Over the years, homecare has broadened health care access ... the health care system by keeping seniors and people ...
Cached Medicine Technology:International Drug & Explosives Detection Company IDenta Corp. Receives Order From Australia 2American Association for Homecare Calls on Joint Deficit Committee in Congress to Preserve Homecare Access for Millions of Americans 2
(Date:6/29/2015)... ... June 29, 2015 , ... ... contractors, nonprofits, independent schools, and other growing businesses across the United States, has ... Value Added Resellers for the fifth consecutive year. , Based on company revenue ...
(Date:6/29/2015)... (PRWEB) , ... June 29, 2015 , ... ... have developed a new approach to build nearly complete genomes by combining high-throughput ... of genomic variation, critically important for their association with human disease, but previously ...
(Date:6/29/2015)... ... June 29, 2015 , ... San Fernando Valley skin doctor ... sagging skin. Ulthera is a special treatment that offers a way to firm sagging ... gently stimulate collagen production. Ulthera is highly targeted and precise to help reduce treatment ...
(Date:6/29/2015)... ... June 29, 2015 , ... ... and Chemical Technology of The Hong Kong Polytechnic University (PolyU) has developed a ... Authentication of edible oils has been a long-term issue in food safety, and ...
(Date:6/29/2015)... ... June 29, 2015 , ... Minneapolis Saint Paul ... Cities area, provides money-saving tactics during a season of increased water and air ... water conservation and other economical practices. , According to the U.S. Department ...
Breaking Medicine News(10 mins):Health News:Brittenford Systems Celebrates Fifth Consecutive Year on Bob Scott Insights Top 100 VARs 2Health News:Brittenford Systems Celebrates Fifth Consecutive Year on Bob Scott Insights Top 100 VARs 3Health News:Mount Sinai Scientists Develop New Approach for More Accurate and Comprehensive Whole Genome Assembly, Variant Discovery and Interpretation 2Health News:Mount Sinai Scientists Develop New Approach for More Accurate and Comprehensive Whole Genome Assembly, Variant Discovery and Interpretation 3Health News:Mount Sinai Scientists Develop New Approach for More Accurate and Comprehensive Whole Genome Assembly, Variant Discovery and Interpretation 4Health News:Dermatologist, Dr. Peyman Ghasri, is Now Offering Non-Invasive Skin Tightening Procedures 2Health News:Dermatologist, Dr. Peyman Ghasri, is Now Offering Non-Invasive Skin Tightening Procedures 3Health News:PolyU develops a new method for rapid authentication of edible oils and screening of gutter oils 2Health News:Save Energy: MSP Plumbing, Heating & Air Endorses Efficiency 2Health News:Save Energy: MSP Plumbing, Heating & Air Endorses Efficiency 3
... reservations on one side and on the other side increasing ... not suffer is the UPA Government’s please-all formula//. ... 27 per cent of the seats in Central educational institutions ... 2007. Simultaneously, it has been decided to increase the number ...
... A group of autoimmune diseases, named Juvenile rheumatoid ... which inversely affect health-related quality of life// , ... adults – study finds. But nothing regarding children ... Research journal published a study in the June ...
... entrance test tomorrow to join the MBBS course at ... Education and Research (JIPMER) here. // ,These ... in Pondicherry, New Delhi, Chennai, Hyderabad, Kolkata and Thiruvananthapuram ... the Dean the institute Dr K S Reddy said ...
... Indian Medical Association today said that private doctors have announced ... for OBCs // , and have decided to close their ... Dental Association, Rajkot, have also extended its support to anti-quota ... release here., ,At least 70 medical students and junior ...
... A study by Florida State University researchers said, ‘Self-critical adult ... they are grown up in a verbally// abused environment in ... times more likely to have symptoms of depression and anxiety ... on 5,614 people aged between 15 and 54, conducted by ...
... planning to bifurcate the Health and Family Welfare Department ... This step is thought to allow for streamlined health ... R Ashok said that the step was being taken ... system. Initially the government will ask 23 doctors who ...
Cached Medicine News:Health News:The Government’s Balancing Act on Reservatio 2Health News:The Government’s Balancing Act on Reservatio 3Health News:Socioeconomic Status Plays A Role In Juvenile Rheumatoid Arthritis 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: