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Roche Starts Early Stage Clinical Trial in Down Syndrome
Date:9/9/2011

e underlying causes of altered brain function in individuals with Down syndrome. Roche's investigational drug is being assessed for its ability to address this imbalance by targeting the GABAergic* system.

*GABA: gamma-amino butyric acid

About the study

This placebo-controlled study will assess the safety and tolerability of the investigational drug in individuals with Down syndrome. It will recruit up to 33 individuals in one or two countries. For more information on the study, access the Roche Clinical Trials Protocol Registry and Results Database:  http://www.roche-trials.com/

About Down syndrome

Down syndrome is the most common genetic cause of intellectual disability and developmental delay, and affects one in every 700-1000 newborns. Also called Trisomy 21, this condition occurs when an individual has three, rather than two, copies of the 21st chromosome. This additional genetic material causes some impairment of cognitive ability and physical growth, and is often associated with other complications ranging from neurological and cardiac defects to hearing and vision problems. It is now thought that many people with Down syndrome are more likely to develop Alzheimer's disease as they age.

About Roche

Headquartered in Basel, Switzerland, Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. Roche is the world's largest biotech company with truly differentiated medicines in oncology, virology, inflammation, metabolism and CNS. Roche is also the world leader in in-vitro diagnostics, tissue-based cancer diagnostics and a pioneer in diabetes management. Roche's personalised healthcare strategy aims at providing medicines and diagnostic tools that enable tangible improvements in the health, quality of life and survival of patients. In 2010, Roche had over 80,000 employees worldwide and in
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