Navigation Links
Roche Diagnostics' HIV Viral Load Test Used in Clinical Trials for Isentress, a New Class of HIV Drug
Date:10/29/2007

Roche HIV-1 monitoring technology used to validate results for Isentress

INDIANAPOLIS, Oct. 29 /PRNewswire/ -- Merck's new integrase inhibitor, Isentress, approved last week by the Food and Drug Administration, used Roche Diagnostics' COBAS(R) HIV-1 AMPLICOR viral load test during its clinical trials.

The new HIV drug, generically known as Raltegravir, is an HIV integrase inhibitor. Integrase inhibitors prevent replication of the virus by blocking insertion of HIV genetic material into human DNA. There are several other HIV integrase inhibitor drugs under development.

Isentress clinical trials researchers followed patients' progress by testing their viral loads with Roche's COBAS(R)HIV-1 AMPLICOR viral load test, which targets the gag region of the HIV virus genome, a different area from the integrase region where many new drugs in the HIV pipeline are being developed. Viral load testing, which quantifies the amount of HIV RNA in a patient's blood, is critical for evaluating response to therapy and as an aid to optimize patient treatment.

"With this new drug classification, it's important to choose an assay that can accurately detect viral load," said Dr. Bill Valenti, founding medical director and staff physician for the AIDS Community Health Center in Rochester, NY. "We've seen evidence of how easily HIV can mutate. If the targeted region mutates during viral load monitoring, the virus may become difficult to detect and quantitate, which may lead to inaccurate information on patients' responses to treatment."

Twenty-one natural polymorphisms and 42 resistance mutations have been identified so far in the integrase region of the HIV genome, according to a 2007 peer reviewed study published in Antiviral Therapy.

Roche's HIV-1 viral load test has been the predominant choice in HIV anti- retroviral clinical drug trials since 1996. Roche has provided research and expertise in comprehensive diagnostic tests for developing HIV ant
'/>"/>

SOURCE Roche Diagnostics
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Aspreva and Roche Announce Preliminary Results for Phase III Study Evaluating CellCept in Lupus Nephritis
2. At the 2007 Alzheimers Association International Conference on the Prevention of Dementia - Neurochems U.S. Principal Investigator Presents Update on Tramiprosate (Alzhemed)
3. New Advances in Gastric Diagnostics: Smaller is Better
4. West Nile Virus Screening and Diagnostics Technology Emerges In Step with North American Outbreak
5. Advanced Viral Research Corp. Announces Positive Preliminary Findings from Ongoing Phase II Dermatological Study
6. Hemispherx Presents Evidence of Ampligen Synergies with Existing Antivirals at International Avian Influenza Conference
7. Sirion Therapeutics Receives Orphan Drug Designation for Ophthalmic Drug to Treat Viral Eye Infection
8. Baraclude (Entecavir) Treatment Demonstrated Greater Viral Load Reduction Compared to Adefovir at 48 Weeks in Study of Antiviral-Naive Chronic Hepatitis B E-Antigen Positive Patients
9. SIGA Passes First Hurdle with Lassa Fever Antiviral ST-193
10. Genelabs Technologies Announces Presentation of Data on Non-Nucleoside HCV Polymerase Inhibitor at 20th International Conference on Antiviral Research Meeting
11. Afid Therapeutics Obtains Positive Evaluation of its Triple Mode Viral Sequestration Agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... April 17, 2015   IBA Molecular, a ... announced today that it has signed a definitive agreement ... Inc. (IBAM NA), to Illinois Health and Science (IHS). Under ... an independent company headquartered in Dulles, Virginia ... advantage of new product and footprint synergies. IBA Molecular ...
(Date:4/17/2015)... DUBLIN , Apr. 16, 2015 Research and ... addition of the "Corporate Reputation of Pharma in ... - 1st Edition" report to their offering. ... has compared opinions on the corporate reputation of the ... in mental health with the views of patient organisations ...
(Date:4/17/2015)... , April 17, 2015 Bionomics Limited ... and development of innovative therapeutics for the treatment of ... announced the presentation of data from three of its ... for Cancer Research (AACR) 106 th Annual Meeting ... Philadelphia, PA USA. The ...
Breaking Medicine Technology:Health Care System to Acquire IBA Molecular North America 2Health Care System to Acquire IBA Molecular North America 3Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 2Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 3Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 2Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 3Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 4Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 5
... , ST. LOUIS, Oct. 30 Stereotaxis received notice ... CE Mark for distribution in the European market. ... from the on-going co-development agreement between Stereotaxis and Biosense ... use in the Niobe Magnetic Navigation System (MNS). ...
... Inc. (NYSE: MTD ) today announced third quarter results for ... in local currency declined by 12% in the quarter. Reported ... , Net earnings per diluted share as reported (EPS) ... Adjusted EPS was $1.36, a 6% decline from the prior-year ...
Cached Medicine Technology:Stereotaxis Receives Notice of European Approval of an Additional Magnetic Irrigated Catheter 2Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 2Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 3Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 4Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 5Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 6Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 7Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 8Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 9Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 10Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 11Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 12Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 13
(Date:4/17/2015)... At the end of February 2015, Choices ... to the Oscars” in the Stardust Penthouse on the ... impressive Los Angeles skyline. These events honoring the 2015 ... leading producer of sustainable product placement in TV and ... providers of eco-friendly and socially conscious products and services, ...
(Date:4/17/2015)... 17, 2015 Testosterone treatment lawsuits ... of prescription medications increases the likelihood that a ... other life-threatening cardiovascular event continue to mount in ... Northern District of Illinois. According to an updated ... on Multidistrict Litigation (JPML) on April 15th, 1,382 ...
(Date:4/17/2015)... Organic Valley, the nation’s largest cooperative of ... Year of Soils by “Cycling for Sustainability” through California ... will travel 215 miles from Auburn, California, to the ... the impact of agriculture on water and soil in ... Wisconsin, Oregon, and Washington state, the cyclists have diverse ...
(Date:4/17/2015)... The American College of Traditional Chinese Medicine (ACTCM) is ... April 29. The event will be held from 11 a.m. to ... St. in San Francisco, CA. , The agenda for the day ... DeHaro campus (room F), 11:10 a.m. – Introduction and welcome ... lunch with current students, faculty and staff, 1 p.m. – Observe ...
(Date:4/17/2015)... NY (PRWEB) April 17, 2015 Calvary Hospital ... Fund, Inc. as Executive Vice President on May 11. The ... unique and historic mission. Barr succeeds Vincent J. Spinelli, who ... has agreed to take on and supervise the important work ... president and CEO. “As Calvary continues to expand and bring ...
Breaking Medicine News(10 mins):Health News:Choices Recovery Speaks with Dakota Hood of “The Hunger Games” about Addiction in Hollywood 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 3Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 4Health News:Organic Valley Farmers and Employees "Cycling for Sustainability" Through 215 Miles of California Watershed April 19-25 2Health News:Organic Valley Farmers and Employees "Cycling for Sustainability" Through 215 Miles of California Watershed April 19-25 3Health News:American College of Traditional Chinese Medicine Hosts Open House 2Health News:Timothy P. Barr Appointed Executive Vice President of Calvary Fund 2Health News:Timothy P. Barr Appointed Executive Vice President of Calvary Fund 3
... been homeless for any period of time after leaving ... accessing health care than those with stable housing situations, ... Archives of Pediatrics & Adolescent Medicine, one of the ... period of time after leaving the foster care system ...
... 1 More than 125 leaders,from throughout the ... joined,together to support a multi-year, statewide campaign to ... campaign, launched by Nemours Health,and Prevention Services (NHPS), ... health professionals, parents, and other leaders to,improve the ...
... the,Supreme Court,s refusal to hear a case defending a ... coverage, Judie Brown,president of American Life League, issued the ... fiat has reached new levels,today as the Supreme Court ... do not want to provide contraceptives as part,of the ...
... Oct. 1 Mylan Laboratories Inc.,(NYSE: MYL ) ... Vice,President and Treasurer, effective October 22, 2007. Mr. Byala ... with responsibility for,treasury planning in both New York and ... in various treasury positions of increasing responsibility.,Prior to Pfizer, ...
... LAWRENCE, Mass., Oct. 1 NxStage Medical, Inc.,(Nasdaq: ... System One(TM) portable,kidney dialysis machine, today announced that ... and certain affiliated entities,("Medisystems") for 6.5 million shares ... we now have the components in place to ...
... 1 A visionary leader, Dr.,Maria Cristina ... her outstanding contributions to the prevention and ... the 27th Pan American Sanitary Conference,proceedings today. ... Health is bestowed upon creative leaders whose ...
Cached Medicine News:Health News:Poor health care access common among youth leaving foster system 2Health News:Poor health care access common among youth leaving foster system 3Health News:More than 125 State Leaders - Including Governor, Lt. Governor, and Congressional Delegation - Endorse Campaign to Make Delaware's Kids the Healthiest in the Nation 2Health News:More than 125 State Leaders - Including Governor, Lt. Governor, and Congressional Delegation - Endorse Campaign to Make Delaware's Kids the Healthiest in the Nation 3Health News:Mylan Announces Appointment of Brian Byala as Senior Vice President and Treasurer 2Health News:NxStage Medical Completes Acquisition of Medisystems 2Health News:NxStage Medical Completes Acquisition of Medisystems 3Health News:Inter-American Leadership Award Bestowed Upon Chilean Chronic Disease Expert 2
Solid 14 mm free-swinging blades, suture posts, and stabilizing disk. Dull finish....
Designed for use with foster enucleation snare (E3670). Package of 12 stainless steel wires. Overall length 5.3 inches....
Open ring design for globe fixation during various ocular procedures. Blunt fixation points. Swivel handle provides increased flexibility. Manufactured in titanium....
Adult size. Loops retract lids. Polished finish....
Medicine Products: