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Roche/Chugai's Bitopertin Will Garner Nearly $1.5 Billion in Major-Market Sales in 2022 as the First Approved Treatment for Negative Symptoms in Schizophrenia
Date:8/22/2013

of depot formulations of two atypical antipsychotics—which are currently available in oral form—will lead to an overall increase in the use of depot formulations across the major markets under study. In particular, Otsuka/Lundbeck's once-monthly Abilify Maintena will provide a more-tolerable option than current depot products, and Janssen's paliperidone palmitate three-month formulation will offer substantial compliance and administration advantages over currently available once-monthly or twice-monthly depots. Together, these two agents are expected to capture major-market sales of nearly $1.8 billion in 2022.

The report finds that the schizophrenia market will grow from $6.3 billion in 2012 to $8.0 billion in 2022, owing to the launch of multiple premium-priced emerging therapies, including bitopertin, Abilify Maintena and paliperidone palmitate three-month depot. Uptake of emerging products will offset the impact of expanding generic competition across the major markets through 2022, including that from three of the four top patient-share leaders in the schizophrenia market, Eli Lilly's olanzapine (Zyprexa, generics), Bristol Myers-Squibb/Otsuka's Abilify and AstraZeneca/Astellas's quetiapine (Seroquel, generics).

In light of a growing generics presence, emerging agents for the treatment of schizophrenia will increasingly be forced to compete with low-cost alternatives of current products and the entrance of multiple new antipsychotics into this crowded market will require emerging therapies to adequately differentiate themselves from their competitors to ensure uptake and to obtain favorable reimbursement status.

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