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Roche/Chugai's Bitopertin Will Garner Nearly $1.5 Billion in Major-Market Sales in 2022 as the First Approved Treatment for Negative Symptoms in Schizophrenia

BURLINGTON, Mass., Aug. 22, 2013 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that Roche/Chugai's glycine transporter-1 inhibitor bitopertin is poised to be the first approved treatment to address negative symptoms in schizophrenia following its forecasted launch in the United States and Europe (France, Germany, Italy, Spain and United Kingdom) in 2016 and in Japan in 2017. As a first-in-class agent for the treatment of these prominent yet underserved symptoms of schizophrenia, Decision Resources expects that bitopertin will garner nearly $1.5 billion in major-market sales in 2022.

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"Treatments for negative symptoms, such as abnormalities in emotional expression and social interaction, is one of the top unmet needs in schizophrenia because—although nearly two-thirds of patients experience notable negative symptoms—currently available antipsychotics have not proven efficacious and reliable in treating such symptoms," said Decision Resources Senior Business Insights Analyst Anne-Elise Tobin, Ph.D. "Bitopertin has engendered enthusiasm from interviewed key opinion leaders, who say its novel mechanism of action will be beneficial as an adjunctive therapy to current antipsychotics. Because bitopertin will be used adjunctively and thus will not compete directly with other currently available therapies, it will contribute to market growth over the forecast period."

The Pharmacor advisory service entitled Schizophrenia also finds that the launch of depot formulations of two atypical antipsychotics—which are currently available in oral form—will lead to an overall increase in the use of depot formulations across the major markets under study. In particular, Otsuka/Lundbeck's once-monthly Abilify Maintena will provide a more-tolerable option than current depot products, and Janssen's paliperidone palmitate three-month formulation will offer substantial compliance and administration advantages over currently available once-monthly or twice-monthly depots. Together, these two agents are expected to capture major-market sales of nearly $1.8 billion in 2022.

The report finds that the schizophrenia market will grow from $6.3 billion in 2012 to $8.0 billion in 2022, owing to the launch of multiple premium-priced emerging therapies, including bitopertin, Abilify Maintena and paliperidone palmitate three-month depot. Uptake of emerging products will offset the impact of expanding generic competition across the major markets through 2022, including that from three of the four top patient-share leaders in the schizophrenia market, Eli Lilly's olanzapine (Zyprexa, generics), Bristol Myers-Squibb/Otsuka's Abilify and AstraZeneca/Astellas's quetiapine (Seroquel, generics).

In light of a growing generics presence, emerging agents for the treatment of schizophrenia will increasingly be forced to compete with low-cost alternatives of current products and the entrance of multiple new antipsychotics into this crowded market will require emerging therapies to adequately differentiate themselves from their competitors to ensure uptake and to obtain favorable reimbursement status.

About Decision Resources

Decision Resources ( is a world leader in market research publications, advisory services and consulting designed to help clients shape strategy, allocate resources and master their chosen markets. Decision Resources is a Decision Resources Group company.

About Decision Resources Group

Decision Resources Group is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resources Group at

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