Navigation Links
Roche/Chugai's Bitopertin Will Garner Nearly $1.5 Billion in Major-Market Sales in 2022 as the First Approved Treatment for Negative Symptoms in Schizophrenia

BURLINGTON, Mass., Aug. 22, 2013 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that Roche/Chugai's glycine transporter-1 inhibitor bitopertin is poised to be the first approved treatment to address negative symptoms in schizophrenia following its forecasted launch in the United States and Europe (France, Germany, Italy, Spain and United Kingdom) in 2016 and in Japan in 2017. As a first-in-class agent for the treatment of these prominent yet underserved symptoms of schizophrenia, Decision Resources expects that bitopertin will garner nearly $1.5 billion in major-market sales in 2022.

(Logo: )

"Treatments for negative symptoms, such as abnormalities in emotional expression and social interaction, is one of the top unmet needs in schizophrenia because—although nearly two-thirds of patients experience notable negative symptoms—currently available antipsychotics have not proven efficacious and reliable in treating such symptoms," said Decision Resources Senior Business Insights Analyst Anne-Elise Tobin, Ph.D. "Bitopertin has engendered enthusiasm from interviewed key opinion leaders, who say its novel mechanism of action will be beneficial as an adjunctive therapy to current antipsychotics. Because bitopertin will be used adjunctively and thus will not compete directly with other currently available therapies, it will contribute to market growth over the forecast period."

The Pharmacor advisory service entitled Schizophrenia also finds that the launch of depot formulations of two atypical antipsychotics—which are currently available in oral form—will lead to an overall increase in the use of depot formulations across the major markets under study. In particular, Otsuka/Lundbeck's once-monthly Abilify Maintena will provide a more-tolerable option than current depot products, and Janssen's paliperidone palmitate three-month formulation will offer substantial compliance and administration advantages over currently available once-monthly or twice-monthly depots. Together, these two agents are expected to capture major-market sales of nearly $1.8 billion in 2022.

The report finds that the schizophrenia market will grow from $6.3 billion in 2012 to $8.0 billion in 2022, owing to the launch of multiple premium-priced emerging therapies, including bitopertin, Abilify Maintena and paliperidone palmitate three-month depot. Uptake of emerging products will offset the impact of expanding generic competition across the major markets through 2022, including that from three of the four top patient-share leaders in the schizophrenia market, Eli Lilly's olanzapine (Zyprexa, generics), Bristol Myers-Squibb/Otsuka's Abilify and AstraZeneca/Astellas's quetiapine (Seroquel, generics).

In light of a growing generics presence, emerging agents for the treatment of schizophrenia will increasingly be forced to compete with low-cost alternatives of current products and the entrance of multiple new antipsychotics into this crowded market will require emerging therapies to adequately differentiate themselves from their competitors to ensure uptake and to obtain favorable reimbursement status.

About Decision Resources

Decision Resources ( is a world leader in market research publications, advisory services and consulting designed to help clients shape strategy, allocate resources and master their chosen markets. Decision Resources is a Decision Resources Group company.

About Decision Resources Group

Decision Resources Group is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resources Group at

All company, brand, or product names contained in this document may be trademarks or registered trademarks of their respective holders.

SOURCE Decision Resources
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. New Survey Reveals How Patients Choose Their Pharmacy; AccentHealth Garners Consumer Insights from the Waiting Room
2. Nearly 300 Medical Device, Healthcare Professionals Attend First National Conference on Value-driven Engineering
3. Evergreen Healthcare Foundation Gala Raises Nearly $1.1 Million to Benefit Breast Health Center
4. Cardinal Health Supports Future Pharmacists With Nearly $1 Million In Scholarships
5. Zarbees Partners with K.I.D.S. by Donating Nearly 23,000 Bottles of All-Natural Cough Syrup to Underserved Families Across the Globe
6. ViiV Healthcare commits nearly £4M in Positive Action for Children Fund grants for programmes focused on alleviating burden of HIV on women and children
7. Global Market for Disposable Medical Supplies To Reach Nearly $200 Billion in 2016
8. Nearly Half of Children Under 2 Years of Age Receive Some Vaccinations Late
9. Surveyed U.S. Pulmonologists Expect to Treat Nearly 50 Percent of Their Severe, Refractory Asthma Patients With a Biologic or Biosimilar Version of Xolair By the End of 2018
10. Nearly 8 Million Healthcare Personnel Come in Contact with Chemotherapy Drugs, According to CDC
11. Nearly 30 Percent of Women Fail to Pick Up New Prescriptions for Osteoporosis, Kaiser Permanente Study Finds
Post Your Comments:
(Date:11/24/2015)... FRANCISCO , Nov. 24, 2015  Thanks to ... Dignity Health St. Mary,s Medical Center,s Sister Diane Grassilli ... breast imaging capabilities in San Francisco ... an anonymous friend, stepped forward with a gift of ... for Breast Digital Mammography with Tomosynthesis and Whole Breast ...
(Date:11/24/2015)... Colo. , Nov. 24, 2015  Array ... that its Chief Executive Officer, Ron Squarer ... Healthcare Conference in New York.  The public is ... webcast on the Array BioPharma website.Event:Piper Jaffray Annual ... , Wednesday, December 2, 2015Time:1:30 p.m. Eastern Time ...
(Date:11/24/2015)... HOUSTON, TX and VANCOUVER, Nov. 24, 2015 /PRNewswire/ ... EPI; NASDAQ: EPIX ) announced today that the ... clinical study of EPI-506 as a treatment for metastatic ... States and Canada.  --> ... --> In the Phase 1/2 clinical trial, ...
Breaking Medicine Technology:
(Date:11/25/2015)... ... November 25, 2015 , ... “While riding the bus, I ... Bronx, N.Y. “I thought there had to be a convenient and comfortable way to ... The PROTECTOR enables disabled individuals to safely travel during cold or inclement weather. In ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible for advancing care ... disease. The Periwinkle Pioneers, nominated by the public, will receive special recognition throughout ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... philanthropic seniors, is resulting in a way for homeless people to have a ... have launched a new initiative whereby they are repurposing plastic bags into sleeping ...
(Date:11/25/2015)... ... November 25, 2015 , ... Since its launch in 2012, ... adult stem cell therapies to patients with chronic degenerative medical conditions. Now, the ... Registered Trademark (RTM). , Organizations are required to hold a registered trademark in ...
(Date:11/24/2015)... ... November 25, 2015 , ... Genesis Chiropractic Software ... software creates an agreement between the practice owner and the patient that automatically ... notification, and projections. Click here to learn more. , ...
Breaking Medicine News(10 mins):