Navigation Links
Roche Announces Positive Results in Solid Tumors Using Human Monoclonal Antibody Against IGF-1R (R1507)
Date:10/23/2007

NUTLEY, N.J., Oct. 23 /PRNewswire/ -- Today, Roche announced positive results from a Phase I trial of R1507, a human monoclonal antibody to target IGF-1R (insulin-like growth factor receptor), in patients with solid tumors. IGF-1 is one of the most potent natural activators of the AKT and MAPK signaling pathways, which promote cell growth and cell survival. The IGF-1R pathway has also been shown to have an important role in mediating the resistance to cytotoxic drugs and EGFR/HER2-targeted agents. The results were reported during the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held in San Francisco.

Study Results

In the Phase I study, R1507 was administered by intravenous infusion. Nine of 34 adult patients with advanced solid tumors experienced disease stabilization. Four of the seven heavily pretreated patients with Ewing's sarcoma demonstrated clinical benefit with two of these patients achieving durable, objective partial responses.

Once a week administration of R1507 was well tolerated with very few side effects. Treatment with R1507 was not associated with the typical side-effects normally observed with cancer therapy (e.g., low blood counts, infection, hair loss, severe nausea and vomiting). The most frequent side effects observed were fatigue, anorexia and weight loss, symptoms that are commonly observed in patients with advanced cancer.

"We are very encouraged by these early results with R1507 in patients with refractory Ewing's sarcoma," said Kapil Dhingra, MD, Head, Oncology Disease Biology Area at Roche. "As a result, we have given this program a very high priority as we believe this molecule has the potential to be very beneficial in treating patients with sarcoma as well as a variety of other solid tumors."

The antibody (R1507) was initially developed under Roche's broad antibody development collaboration with Genmab, which began in 2001.

The Phase I study is being con
'/>"/>

SOURCE Hoffmann-La Roche Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Aspreva and Roche Announce Preliminary Results for Phase III Study Evaluating CellCept in Lupus Nephritis
2. At the 2007 Alzheimers Association International Conference on the Prevention of Dementia - Neurochems U.S. Principal Investigator Presents Update on Tramiprosate (Alzhemed)
3. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
4. Sygnis Pharma AG announces date for presentation of clinical results
5. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
6. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
7. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
8. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
9. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
10. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
11. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... July 10, 2014   LabStyle Innovations Corp ... today announced the appointment of Professor Richard ... its Board of Directors. Prof. Stone ... experience to LabStyle as an entrepreneur, venture capitalist ... corporate governance expert. He currently serves on the ...
(Date:1/15/2014)... ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry Report, 2013-2015" research ... http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting from aging of ... orthopedic instrument industry has seen rapid development ... 3.28 billion yuan in 2006 to 9.85 billion yuan ...
(Date:1/15/2014)... , Jan. 15, 2014 AARP Foundation today announced it ... adults suffering from the severe cold weather that has gripped ... to helping those in need; so to support these emergency ... up to $250,000, which could mean up to $500,000 in ...
Breaking Medicine Technology:LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
(Date:7/11/2014)... Presently, disposable medical suppliers call for ... supplies segment. During the past two decades, the world ... an average 12.5% per year), primarily owing to the ... US is the largest market for disposable medical supplies ... The second position is held by Europe with a ...
(Date:7/11/2014)... York, NY (PRWEB) July 11, 2014 ... during the five years to 2014 on the heels ... of 2010 prompted farmers to dedicate a larger share ... ethanol production. More specifically, the regulations required the mixing ... rapidly expanding biofuel production in the United States created ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Ticket Down ... Tickets at the Sleep Train Amphitheatre in Wheatland, CA. ... that can compare to what the Sleep Train Amphitheatre can ... events and special attractions over the course of its existence ... the Sleep Train Amphitheatre in Wheatland (Sacramento metro area) will ...
(Date:7/11/2014)... July 11, 2014 Pigments are insoluble ... mainly three functions namely protective coating, opacity, and coloring. ... materials that impart color to substances such as paper, ... the pigments, which upon application impart color to the ... oxide, carbon black, and hematite. , The coloring action ...
(Date:7/11/2014)... 11, 2014 With the arrival of ... seeking cosmetic surgery and hair transplant procedures, up 80 ... expansive range of medical tourism destinations, the company is ... costs and achieve the look they have always ... the top name in the medical tourism industry, VisitandCare.com ...
Breaking Medicine News(10 mins):Health News:Global Disposable Medical Supplies Market to See Robust Growth Through Next Decade, According to New TriMark Report Available at MarketPublishers.com 2Health News:Global Disposable Medical Supplies Market to See Robust Growth Through Next Decade, According to New TriMark Report Available at MarketPublishers.com 3Health News:Corn Farming in Canada Industry Market Research Report Now Available From IBISWorld 2Health News:Corn Farming in Canada Industry Market Research Report Now Available From IBISWorld 3Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 2Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 3Health News:Americas Pigments Market Worth 1,099 Thousand MT by 2018 - New Report by MicroMarket Monitor 2Health News:Americas Pigments Market Worth 1,099 Thousand MT by 2018 - New Report by MicroMarket Monitor 3Health News:VisitandCare.com Reports Increase in Cosmetic and Hair Transplant Procedures for Men 2Health News:VisitandCare.com Reports Increase in Cosmetic and Hair Transplant Procedures for Men 3
... actually face tough times in life, are better equipped to ... revealed exactly// the contrary. A finding from the University of ... are vulnerable to deception rather than those who have grown ... School of Psychology found that rather than 'toughening up' individuals, ...
... researchers at the Washington University and the Group Health Centre ... regular exercise keeps Alzheimer’s at bay. It was initially thought ... now it is been disproved by the researchers. The researchers ... and a weak handshake are early signs of dementia. They ...
... highlighted the beneficial effects of consuming flavanol-rich cocoa on ... Journal of Nutrition//. ,Researchers found that certain ... of women's skin – increasing hydration, decreasing skin roughness ... against UV damage. The German scientists attributed the observed ...
... very same day Prince Charles urges the World Health ... and complementary medicines alongside scientifically// proven treatments, some of ... medicine into the NHS. ,Thirteen senior doctors ... British medicine have written to every hospital and primary ...
... Progress as we know it, has an expensive price tag ... hundred years has brought,tremendous wealth and opportunity to its people;// ... there are 30% Americans who are,over-weight or grossly obese. More ... land the country in a similar situation.,India has seen a ...
... beverages by the FDA (Food and Drug Administration), US indicated ... carcinogen in much higher amount than the recommended 5 parts ... these companies, and they had either decided to reformulate the ... had expressed concern regarding this, it was not an issue, ...
Cached Medicine News:Health News:Take it if you can - Tough Times in Life Churn out Greenhorns 2Health News:Take it if you can - Tough Times in Life Churn out Greenhorns 3Health News:Cocoa good for skin? 2Health News:Eminent Doctors In UK Wants The NHS To Abandon Alternative Medicines: 2Health News:The Price Paid for New Lifestyle 2Health News:Soda Drinks Contain Benzene - A Carcinogen, Reports FDA 2Health News:Soda Drinks Contain Benzene - A Carcinogen, Reports FDA 3
Super High Density 360 degree radial rectal transducer. High resolution in the near field and lower frequencies for deeper penetration make this transducer the optimal choice when scanning the anal c...
Multi-frequency, HST, linear transducer with a longer (60mm) footprint. Available with puncture adapter and water path. This transducer incorporates ALOKAs exclusive Hemispheric Sound Technology and ...
... Linear high frequency ... breast and superficial ... exclusive Hemispheric Sound ... technologies. This multi-frequency ...
This versatile convex array abdominal transducer is multi-frequency, offering 5 levels of fundamental frequencies in addition to 4 settings of Harmonic frequencies. This transducer provides superb im...
Medicine Products: